scholarly journals The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys: a pilot study

Author(s):  
Emma J. Cockcroft ◽  
Bert Bond ◽  
Craig A. Williams ◽  
Sam Harris ◽  
Sarah R. Jackman ◽  
...  

Abstract Background Current evidence of metabolic health benefits of high-intensity interval training (HIIT) are limited to longer training periods or conducted in overweight youth. This study assessed 1) fasting and postprandial insulin and glucose before and after 2 weeks of HIIT in healthy adolescent boys, and 2) the relationship between pre intervention health outcomes and the effects of the HIIT intervention. Methods Seven healthy boys (age:14.3 ± 0.3 y, BMI: 21.6 ± 2.6, 3 participants classified as overweight) completed 6 sessions of HIIT over 2 weeks. Insulin resistance (IR) and blood glucose and insulin responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), 20 h and 70 h after (POST) the final HIIT session. Results Two weeks of HIIT had no effect on fasting plasma glucose, insulin or IR at 20 h and 70 h POST HIIT, nor insulin and glucose response to MMTT (all P > 0.05). There was a strong negative correlation between PRE training IR and change in IR after HIIT (r = − 0.96, P < 0.05). Conclusion Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes in a group of adolescent boys. However the negative correlation between PRE IR and improvements after HIIT suggest that interventions of this type may be effective in adolescents with raised baseline IR.

2019 ◽  
Author(s):  
Emma Cockcroft ◽  
Bert Bond ◽  
Craig A Williams ◽  
Sam Harris ◽  
Sarah R Jackman ◽  
...  

Abstract Background : Current evidence of metabolic health benefits of high-intensity interval training (HIIT) are limited to longer training periods or conducted in overweight youth. This study assessed 1) fasting and postprandial insulin and glucose before and after two weeks of HIIT in healthy adolescent boys, and 2) the relationship between pre intervention health outcomes and the effects of the HIIT intervention. Methods: Seven healthy boys (age:14.3 ± 0.3 y, BMI: 21.6 ± 2.6, 3 participants classified as overweight) completed 6 sessions of HIIT over two weeks. Insulin resistance (IR) and blood glucose and insulin responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), 20 h and 70 h after (POST) the final HIIT session. Results: Two weeks of HIIT had no effect on fasting plasma glucose, insulin or IR at 20 h and 70 h POST HIIT, nor insulin and glucose response to MMTT (all P>0.05). There was a strong negative correlation between PRE training IR and change in IR after HIIT (r =-0.96, P <0.05). Conclusion: Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes in a group of adolescent boys. However the negative correlation between PRE IR and improvements after HIIT suggest that interventions of this type may be effective in adolescents with raised baseline IR.


2019 ◽  
Author(s):  
Emma Cockcroft ◽  
Bert Bond ◽  
Craig A Williams ◽  
Sam Harris ◽  
Sarah R Jackman ◽  
...  

Abstract Background This study examined whether improvements in fasting and postprandial [insulin], [glucose] and aerobic fitness are possible after two weeks of high-intensity interval training (HIIT) in adolescent boys. Methods Seven boys (14.3 ± 0.3 y) completed 6 sessions of HIIT over two weeks. Homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting glucose:insulin ratio (FGIR) and blood [glucose] and [insulin] responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), and 20 h and 70 h after (POST) the final HIIT session. Maximal oxygen uptake (VO2 max) was assesed PRE and 70 h POST. Results Compared to PRE, two weeks of HIIT had no effect on fasting plasma [glucose] or [insulin] or HOMA-IR at 20 h and 70 h POST. However, a strong negative correlation was observed between PRE training HOMA-IR, QUICKI and FGIR, and change in HOMA-IR, FGIR and QUICKI at 20 h POST (r =-0.96, 0.969 and 0.826 for HOMA-IR, QUICKI and FGIR respectively all P<0.05). Plasma [insulin] and [glucose] area under the curve in the postprandial period following the MMTT were unchanged 20 h and 70 h POST compared to PRE. Conclusion Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes or aerobic fitness in a group of adolescent boys. Interventions of this type may, however, be effective in adolescents with raised baseline IR.


2018 ◽  
Vol 9 ◽  
Author(s):  
Mariana Aguiar de Matos ◽  
Dênia Vargas Vieira ◽  
Kaio Cesar Pinhal ◽  
Jennifer Freitas Lopes ◽  
Marco Fabrício Dias-Peixoto ◽  
...  

Author(s):  
Sajad Ahmadizad ◽  
Alireza Salimi Avansar ◽  
Khosrow Ebrahim ◽  
Mohsen Avandi ◽  
Mansour Ghasemikaram

AbstractExercise training is an effective method of weight management, and knowing about its influence on the hormones involved in the regulation of food intake and inflammation could be useful for body weight management. Therefore, the purpose of this study was to compare the effects of 6 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT) on nesfatin-1, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α).Thirty sedentary overweight men (Mean±SD; age, 25±1 years) were divided into three (n=10) body mass index-matched groups. The participants in the training groups performed either HIIT or MCT protocols 3 days per week for 6 weeks followed by a week of detraining.Plasma IL-6 and TNF-α did not significantly change after training, but nesfatin increased significantly only with HIIT compared with the control group (p<0.05). In addition, fasting glucose, insulin, and homeostasis model estimated insulin resistance (HOMA-IR), decreased significantly following both HIIT and MCT training (p<0.05). After a detraining period, the plasma nesfatin-1 did not return to pre-training levels in the HIIT group.Both the HIIT and MCT groups had similar effects on inflammatory markers and insulin resistance in men who are overweight, but the HIIT seems to have better anorectic effects (as indicated by nesfatin) compared with MCT.


2017 ◽  
Vol 60 (1) ◽  
pp. 67-77 ◽  
Author(s):  
Trine Karlsen ◽  
Inger-Lise Aamot ◽  
Mark Haykowsky ◽  
Øivind Rognmo

2018 ◽  
Vol 32 (6-7) ◽  
pp. 543-556 ◽  
Author(s):  
Jennifer Crozier ◽  
Marc Roig ◽  
Janice J. Eng ◽  
Marilyn MacKay-Lyons ◽  
Joyce Fung ◽  
...  

Introduction. Stroke is the leading cause of adult disability. Individuals poststroke possess less than half of the cardiorespiratory fitness (CRF) as their nonstroke counterparts, leading to inactivity, deconditioning, and an increased risk of cardiovascular events. Preserving cardiovascular health is critical to lower stroke risk; however, stroke rehabilitation typically provides limited opportunity for cardiovascular exercise. Optimal cardiovascular training parameters to maximize recovery in stroke survivors also remains unknown. While stroke rehabilitation recommendations suggest the use of moderate-intensity continuous exercise (MICE) to improve CRF, neither is it routinely implemented in clinical practice, nor is the intensity always sufficient to elicit a training effect. High-intensity interval training (HIIT) has emerged as a potentially effective alternative that encompasses brief high-intensity bursts of exercise interspersed with bouts of recovery, aiming to maximize cardiovascular exercise intensity in a time-efficient manner. HIIT may provide an alternative exercise intervention and invoke more pronounced benefits poststroke. Objectives. To provide an updated review of HIIT poststroke through ( a) synthesizing current evidence; ( b) proposing preliminary considerations of HIIT parameters to optimize benefit; ( c) discussing potential mechanisms underlying changes in function, cardiovascular health, and neuroplasticity following HIIT; and ( d) discussing clinical implications and directions for future research. Results. Preliminary evidence from 10 studies report HIIT-associated improvements in functional, cardiovascular, and neuroplastic outcomes poststroke; however, optimal HIIT parameters remain unknown. Conclusion. Larger randomized controlled trials are necessary to establish ( a) effectiveness, safety, and optimal training parameters within more heterogeneous poststroke populations; (b) potential mechanisms of HIIT-associated improvements; and ( c) adherence and psychosocial outcomes.


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