scholarly journals Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Juan Li ◽  
Yu-hong Wang ◽  
Fu-ling Zheng ◽  
Xin-yue Chen ◽  
Yun Lin ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Low Dose ◽  
Celiac Artery ◽  
High Concentration ◽  
Virtual Monoenergetic Imaging ◽  
Enhanced Ct ◽  
Pancreatic Artery ◽  
Monoenergetic Imaging ◽  
Angiographic Image ◽  
Pancreatic Arteries

Abstract Objectives The least amount of contrast medium (CM) should be used under the premise of adequate diagnosis. The purpose of this study is to evaluate the feasibility of utilizing ultra-low-dose (224 mgI/kg) CM for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging (VMI+) and high-concentration (400 mgI/mL) CM. Materials and methods 41 patients who underwent both normal dose CM (ND-CM, 320 mgI/kg) and low dose CM (LD-CM, 224 mgI/kg) thoracoabdominal enhanced CT for tumor follow-up were prospectively included. The VMI+ at the energy level of 40-kev for LD-CM images was reconstructed. CT attenuation, signal-to-noise ratios (SNRs), and contrast-to-noise ratios (CNRs) of the abdominal artery, celiac artery, and superior mesenteric artery (SMA) and qualitative scores of pancreatic arteries depiction were recorded and compared among the three groups (ND-CM, LD-CM, and VMI+ LD-CM images). ANOVA and Friedman tests were used for statistical analysis. Results All quantitative and qualitative parameters on LD-CM images were lower than that on ND-CM images (all p < 0.01). There were no significant differences of all arteries’ qualitative scores between ND-CM and VMI+ LD-CM images (all p > 0.05). VMI+ LD-CM images had the highest mean CT and CNR values of all arteries (all p < 0.0001). The CM volume was 52.6 ± 9.4 mL for the ND-CM group and 37.0 ± 6.7 mL for the LD-CM group. Conclusion Ultra-low-dose CM (224 mgI/kg) was feasible for depicting pancreatic arteries. Inferior angiographic image quality could be successfully compensated by VMI+ and high-concentration CM.

A Systematic Review of Double Low-dose CT Pulmonary Angiography in Pulmonary Embolism

2019 ◽  
Vol 15 (5) ◽  
pp. 453-460 ◽  
Author(s):  
Sultan Aldosari ◽  
Zhonghua Sun
Keyword(s):  
Systematic Review ◽  
Pulmonary Embolism ◽  
Image Quality ◽  
Radiation Dose ◽  
Contrast Medium ◽  
Low Dose ◽  
Pulmonary Angiography ◽  
Ct Pulmonary Angiography ◽  
Low Contrast ◽  
Low Contrast Medium

Background: The aim of this study is to perform a systematic review of the feasibility and clinical application of double low-dose CT pulmonary angiography (CTPA) in the diagnosis of patients with suspected pulmonary embolism. Discussion: A total of 13 studies were found to meet selection criteria reporting both low radiation dose (70 or 80 kVp versus 100 or 120 kVp) and low contrast medium dose CTPA protocols. Lowdose CTPA resulted in radiation dose reduction from 29.6% to 87.5% in 12 studies (range: 0.4 to 23.5 mSv), while in one study, radiation dose was increased in the dual-energy CT group when compared to the standard 120 kVp group. CTPA with use of low contrast medium volume (range: 20 to 75 ml) was compared to standard CTPA (range: 50 to 101 ml) in 12 studies with reduction between 25 and 67%, while in the remaining study, low iodine concentration was used with 23% dose reduction achieved. Quantitative assessment of image quality (in terms of signal-to-noise ratio and contrast-to-noise ratio) showed that low-dose CTPA was associated with higher, lower and no change in image quality in 3, 3 and 6 studies, respectively when compared to the standard CTPA protocol. The subjective assessment indicated similar image quality in 11 studies between low-dose and standard CTPA groups, and improved image quality in 1 study with low-dose CTPA. Conclusion: This review shows that double low-dose CTPA is feasible in the diagnosis of pulmonary embolism with significant reductions in both radiation and contrast medium doses, without compromising diagnostic image quality.

scholarly journals Transcirculation microballoon-assisted coil embolization for dorsal pancreatic artery aneurysm due to celiac artery dissection: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2098734
Author(s):  
Yuki Takara ◽  
Daisuke Yunaiyama ◽  
Toru Saguchi ◽  
Natsuhiko Shirota ◽  
Takafumi Yamada ◽  
...  
Keyword(s):  
Case Report ◽  
Coil Embolization ◽  
Balloon Catheter ◽  
Artery Aneurysm ◽  
Celiac Artery ◽  
Endovascular Surgery ◽  
Artery Dissection ◽  
Dorsal Pancreatic Artery ◽  
Pancreatic Artery

The dorsal pancreatic artery is a part of peripancreatic arcade connecting celiac artery to transpancreatic artery. A dorsal pancreatic artery aneurysm derived from dissection of celiac artery is a rare pathology, and it sometimes requires ingenious strategy in an endovascular surgery. Hereby, we report a case of a patient who underwent coil embolization for dorsal pancreatic artery aneurysm due to celiac artery dissection by applying transcirculation approach of a balloon catheter through the peripancreatic arcade, which was successfully achieved.

Effect of hypothalamic neuropeptides on corticotrophin release from quarters of rat anterior pituitary gland in vitro

1984 ◽  
Vol 100 (2) ◽  
pp. 219-226 ◽  
Author(s):  
S. A. Nicholson ◽  
T. E. Adrian ◽  
B. Gillham ◽  
M. T. Jones ◽  
S. R. Bloom
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Low Dose ◽  
Physiological Role ◽  
Anterior Pituitary Gland ◽  
High Concentration ◽  
Response Curves ◽  
Corticotrophin Releasing Factor ◽  
Basal Release

ABSTRACT The effect of six hypothalamic peptides on the basal release of ACTH and that induced by arginine vasopressin (AVP) or by ovine corticotrophin releasing factor (oCRF) from fragments of the rat anterior pituitary gland incubated in vitro was investigated. Dose–response curves to AVP and to oCRF were obtained, and the response to a low dose of oCRF was potentiated by a low dose of AVP. Basal release of ACTH was not affected by any of the peptides in concentrations in the range 10−12 to 10−6 mol/l, and only substance P (SP) and somatostatin (SRIF) inhibited significantly the response to oCRF in a dose-related manner. The responses to a range of doses of oCRF or AVP were reduced by 10−8 and 10 − 6 mol SP or SRIF/1, and to a greater extent by the higher dose. Except in the case of 10−6 mol SRIF/1 on the response to AVP, the response was not further diminished by preincubation of the tissue with the peptide before the stimulating agent was added. The inhibition of the responses to AVP or oCRF by 10−9 mol SP/1 was not potentiated by its combination with either 5 × 10−10 or 10−8 mol SRIF/1; the inhibitory effects were merely additive. The results suggest that although SRIF and SP are able to modulate the release of ACTH from the anterior pituitary gland, they do so only at a high concentration. In the case of SRIF these concentrations are several orders of magnitude higher than those reported to be present in the hypophysial portal blood and therefore a physiological role for this peptide in the control of ACTH secretion is unlikely. J. Endocr. (1984) 100, 219–226

scholarly journals Feasibility of Low-Dose Contrast Medium High Pitch CT Angiography for the Combined Evaluation of Coronary, Head and Neck Arteries

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90268 ◽  
Author(s):  
Zhiwei Wang ◽  
Yu Chen ◽  
Yining Wang ◽  
Huadan Xue ◽  
Zhengyu Jin ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Head And Neck ◽  
Ct Angiography ◽  
Low Dose ◽  
High Pitch ◽  
Combined Evaluation

ABNORMAL vWF IN CONGENITAL CARDIAC DISEASE: EVIDENCE FOR FRAGMENTATION

1987 ◽  
Author(s):  
J C Gill ◽  
S Baganz ◽  
J Endres-Brooks ◽  
R R Montgomery
Keyword(s):  
Low Dose ◽  
Von Willebrand Disease ◽  
High Concentration ◽  
Agarose Gels ◽  
Crossed Immunoelectrophoresis ◽  
Congenital Cardiac Disease ◽  
Agarose Electrophoresis ◽  
Cardiac Lesions ◽  
Von Willebrand ◽  
Willebrand Factor

We previously reported the presence of an acquired von Willebrand factor (vWF) abnormality characterized by absence of the highest molecular weight (raw) multimers in 12 children with non-cyanotic congenital cardiac lesions. In order to determine the prevalence and define the mechanism of the vWF defect, a prospective series of 17 children were studied at the time of cardiac catheterization. In addition to standard coagulation and vWF assays, vWF multimeric patterns were determined by SDS agarose electrophoresis using two agarose concentrations, low concentration (0.65%) and high concentration (3.0%). Nine of the 17 children had absence of high mw vWF multimers on 0.65% agarose gels as follows:Of 5 children with absence of high mw vWF multimers on 0.65% agarose gels, 4 had 3% agarose gel patterns similar to that seen in patients with Type IIA von Willebrand disease (vWd). Two of 3 studied had the presence of vWF:frag on crossed immunoelectrophoresis. The patterns were not different when samples were drawn into a "cocktail" of proteolytic inhibitors. There was no correlation of abnormal vWF multimers with elevated B thromboglobulin, low dose ristocetin induced platelet aggregation or abnormal platelet vWF subunits. Thus, abnormal vWF multimers are commonly associated with non-cyanotic congenital cardiac lesions, particularly VSD. The lack of abnormality in platelet vWF multimers, absent low dose ristocetin aggregation, and presence of vWF:frag suggests that these alterations may be secondary to fragmentation or are of endothelial cell origin.

Nephrotoxic Polypharmacy and Risk of Contrast Medium–Induced Nephropathy in Hospitalized Patients Undergoing Contrast-Enhanced CT

2015 ◽  
Vol 205 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Yunn-Fang Ho ◽  
Kun-Lin Hsieh ◽  
Fan-Lu Kung ◽  
Fe-Lin Lin Wu ◽  
Ling-Ling Hsieh ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Hospitalized Patients ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct

CT angiography for pulmonary embolism in the emergency department: investigation of a protocol by 20 ml of high-concentration contrast medium

2019 ◽  
Vol 125 (2) ◽  
pp. 137-144
Author(s):  
Mario Silva ◽  
Gianluca Milanese ◽  
Rocco Cobelli ◽  
Carmelinda Manna ◽  
Edoardo Rasciti ◽  
...  
Keyword(s):  
Emergency Department ◽  
Pulmonary Embolism ◽  
Contrast Medium ◽  
Ct Angiography ◽  
High Concentration
Sign in / Sign up

Export Citation Format

Share Document