Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon

Background : Dermatological disorders are cutaneous infirmities that are frequently occurring and increasing at an alarming rate. These range from mild itching/redness (dermatitis) to fatal skin cancers and have posed a major health concern. Azadirachta indica A. Juss (commonly known as neem), a member of the Meliaceae family, is an Indian medicinal plant that has been known for its health-promoting effects since ancient times. Objective: The review highlights the traditional practices, pharmacological aspects, and formulation approach of neem for the treatment of dermatological disorders. Further, recent patents and novel delivery systems (developed and in the pipeline) improving skin delivery and the therapeutic profile of neem are discussed. Results : Neem is a traditional medicinal plant that has been employed for the prevention and treatment of numerous ailments covering systemic and topical disorders. Scientific studies have validated the traditional claims of neem and attributed these health benefits to the present more than 300 structurally diverse and complex compounds. It possesses anti-inflammatory, antibacterial, analgesic, antiviral, antifungal, immunomodulatory, and antioxidant activities which substantiate its use as skin therapy. Various novel formulations and associated patents that improved the permeability of neem-based products across skin could be found in the literature. Conclusion : Critical appraisal of available literature revealed that neem possesses anti-microbial, anti-inflammatory, antioxidant, and antiseptic properties. Thus it has the potential to be developed as a single effective therapy for the management of multimodal skin disorders. Further, pharmaceutical tailoring of neem by implication of novel carriers could enhance its penetrability across the skin.

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Evaluation of phytochemical constituents, analgesic, anti-inflammatory, antimicrobial and antioxidant activities of extracts of Breynia nivosa leaves

Planta Medica ◽

10.1055/s-0034-1395078 ◽

2014 ◽

Vol 80 (16) ◽

Cited By ~ 1

Author(s):

FA Onyegbule ◽

IO Ilouno ◽

C Ikeh ◽

BO Umeokoli ◽

PM Eze

Keyword(s):

Antioxidant Activities ◽

Phytochemical Constituents ◽

Anti Inflammatory

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Evaluation of phytochemicals, antimicrobial, anti-inflammatory and antioxidant activities of extracts of Luffa cylindrica leaves

Planta Medica ◽

10.1055/s-0034-1395077 ◽

2014 ◽

Vol 80 (16) ◽

Author(s):

FA Onyegbule ◽

C Okoye ◽

C Ikeh ◽

BO Umeokoli ◽

AU Emezie

Keyword(s):

Antioxidant Activities ◽

Luffa Cylindrica ◽

Anti Inflammatory

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Pharmacognostical fingerprinting and selective bioactivity studies of Solanum glaucophyllum Desf.

Journal of Traditional and Folk Practices ◽

10.25173/jtfp.2018.6.1.87 ◽

2018 ◽

Vol 6 (1) ◽

Author(s):

Anindya Sundar Ray ◽

Suman Kalyan Mandal ◽

Chowdhury Habibur Rahaman

Keyword(s):

Medicinal Plant ◽

Radical Scavenging ◽

Ethanol Extract ◽

Inhibition Zone ◽

Phytochemical Analysis ◽

Antimicrobial Studies ◽

Maximum Inhibition ◽

Crude Drugs ◽

Phytochemical Studies ◽

Dpph Radical Scavenging

Solanum glaucophyllum Desf. (Solanaceae) is traditionally used for curing several health conditions in both human and domesticated animals. There is no data available regarding pharmacognostic standardization and pharmacological activity of this less known medicinal plant. Therefore, the aim of the present work is to prepare pharmacognostic fingerprints of crude drugs obtained from the leaf and stem parts of S. glaucophyllum. Apart from this detailed phytochemical analysis, antioxidant and antimicrobial studies have also been carried out. Pharmacognostic study revealed that the leaves are amphistomatic and stomata are strictly of anisocytic type. Values of stomatal index, palisade ratio, ash content of the investigated parts are found distinct and can be used as pharmacognostic standards for evaluation of crude drugs of this medicinal plant. Phytochemical studies of the leaf and stem parts indicated that phenolics, flavonoids, tannins and alkaloids are present in quite impressible amount. Curcumin content in stem was found very high through HPLC analysis. In DPPH radical scavenging assay, the stem part showed significant antioxidant potential. Ethanol extract of stem produced maximum inhibition zone (11mm) against Pseudomonas aeruginosa at the concentration of 50 mg/ml among five test microorganisms. Some pharmacognostic features recorded in this study as diagnostic ones will help in proper identification of this ethnomedicinal plant in its fresh as well as dried form. On the other hand preliminary phytochemical, antioxidant and antimicrobial studies highlight the S. glaucophyllum as a promising candidate for bioprospecting.

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Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

Current Medicinal Chemistry ◽

10.2174/0929867326666191212102407 ◽

2020 ◽

Vol 28 (2) ◽

pp. 360-376 ◽

Cited By ~ 7

Author(s):

Atefeh Amiri ◽

Maryam Mahjoubin-Tehran ◽

Zatollah Asemi ◽

Alimohammad Shafiee ◽

Sarah Hajighadimi ◽

...

Keyword(s):

Molecular Mechanisms ◽

Antioxidant Activities ◽

Natural Compounds ◽

Therapeutic Effects ◽

Inflammatory Disorder ◽

Inflammatory Disorders ◽

Therapeutic Modalities ◽

Anti Cancer ◽

Current Therapies ◽

Anti Inflammatory

: Cancer and inflammatory disorders are two important public health issues worldwide with significant socio.economic impacts. Despite several efforts, the current therapeutic platforms are associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural compounds could be used either alone or in combination with the standard cancer therapeutic modalities such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound that is found in grapes as well as other foods. It has been found that this medicinal agent displays a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic effects by targeting various cellular and molecular mechanisms. Among cellular and molecular targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in many processes that are involved in the initiation and progression of cancer and inflammatory disorders. Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in cancer and inflammatory disorders.

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Antioxidant Activities of Medicinal Plant Fagraea ceylanica from Western Ghats, Southern India

Current Nutrition & Food Science ◽

10.2174/1573401313666170712105159 ◽

2019 ◽

Vol 14 (5) ◽

pp. 406-413

Author(s):

Sapna P. Vasanthkumar ◽

Ambarish C. Nair

Keyword(s):

Medicinal Plant ◽

Western Ghats ◽

Antioxidant Activities ◽

Southern India

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Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

Zeitschrift für Naturforschung C ◽

10.1515/znc-2020-0257 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Gamze Göger ◽

Muhammed Allak ◽

Ali Şen ◽

Fatih Göger ◽

Mehmet Tekin ◽

...

Keyword(s):

Fatty Acids ◽

Essential Oil ◽

Antioxidant Activities ◽

Antimicrobial Activities ◽

Antidiabetic Activity ◽

Gram Negative Bacteria ◽

Inhibitory Effects ◽

Dicaffeoylquinic Acid ◽

Anti Inflammatory ◽

Phytochemical Profiles

Abstract Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.

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