scholarly journals Cost-effectiveness of palivizumab in infants with congenital heart disease: a Swedish perspective

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Eva Fernlund ◽  
Martin Eriksson ◽  
Jonas Söderholm ◽  
Jan Sunnegårdh ◽  
Estelle Naumburg
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cost Effectiveness ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Cost Savings ◽  
Life Years ◽  
Increased Risk ◽  
Syncytial Virus ◽  
One Year

Abstract Background Infants with congenital heart disease (CHD) have an increased risk of morbidity and mortality during a respiratory syncytial virus (RSV) infection. The aim of this study was to estimate the cost-effectiveness of palivizumab as RSV-prophylaxis among infants with CHD, including the effect of delayed heart surgery and asthma. Methods A simulation model with data from the literature and health care authorities including costs and utilities was developed to estimate costs and health effects over a lifetime for a cohort of CHD infants receiving palivizumab compared to no RSV-prophylaxis. Results The prophylaxis treatment incurred a cost of 3664 EUR per treated infant. However, due to cost-savings from primarily avoiding hospitalizations (5145 EUR/treated infant) and avoiding heart complications due to delayed heart surgery (2082 EUR/treated infant), the RSV-prophylaxis treatment resulted in a total cost-saving of 3833 EUR per treated infant. At the same time, the prophylaxis-treated cohort accumulated more life-years and higher quality of life than the non-prophylaxis cohort. Conclusion This study confirms that RSV-prophylaxis in severe CHD infants less than one year of age is cost beneficial. Avoiding delayed heart surgeries is an important benefit of prophylaxis and should be taken into consideration.

scholarly journals Respiracinio sincitinio viruso infekcijos aktualumas vaikų kardiochirurgijoje

2007 ◽  
Vol 5 (3) ◽  
pp. 0-0
Author(s):  
Solveiga Umbrasaitė ◽  
Kęstutis Versockas
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Respiratory Syncytial Virus ◽  
Congenital Heart ◽  
Severe Form ◽  
University Hospital ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
One Year ◽  
Tract Infections

Solveiga Umbrasaitė, Kęstutis VersockasVilniaus universiteto ligoninės Santariškių klinikos, Santariškių g. 2, LT-08661 VilniusEl paštas: [email protected] Įvadas / tikslas Respiracinis sincitinis virusas (RSV) yra dažniausia apatinių kvėpavimo takų infekcijos priežastis, ypač naujagimiams ir kūdikiams. Tarp vaikų, kuriems yra padidėjusi sunkios RSV infekcijos formos rizika, yra turinčių įgimtą širdies ydą. Ši rizika yra dar didesnė atliekant širdies operacijas. Šio tyrimo tikslas buvo išsiaiškinti, kiek yra infekuotų RSV vaikų tarp patenkančių į stacionarą operaciniam gydymui. Metodai ir rezultatai Specifiniai RSV imunoglobulinų testai buvo atlikti 32 vaikų grupėje (iš kurių 9 naujagimiai ir 23 kūdikiai). Teigiamų IgG antikūnų rasta 12 atvejų (41%), teigiamų IgM antikūnų – vienu. Išvados RSV infekuotų vaikų yra gana daug; dėl to tikslinga tęsti tyrimus. Kitas žingsnis būtų išsiaiškinti RSV infekcijos įtaką perioperacinei pacientų būklei ir pasyvios imunoprofilaktikos palivizumabu tikslingumą. Pagrindiniai žodžiai: respiracinis sincitinis virusas, įgimtos širdies ydos, imunoprofilaktika Relevance of RSV infection in children’s cardiac surgery Solveiga Umbrasaitė, Kęstutis VersockasVilnius University Hospital „Santariškių klinikos“, Santariškių str. 2, LT-08661 Vilnius, LithuaniaE-mail: [email protected] Background / objective Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections, especially in newborns and children under one year of age. Among children at a higher risk of a severe form of RSV infection are children with congenital heart disease. This risk is higher in case of heart operation.The purpose of this research was to reveal the incidence of RSV-infected patients among those admitted for surgical treatment. Methods and results Specific RSV immunoglobulin tests were performed for a group of 32 children (9 newborns and 23 infants). Positive IgG antibodies were found in 12 cases (41%) and positive IgM antibodies in one case. Conclusions The incidence of RSV-infected children is quite high; therefore, it is purposeful to continue research. The next step would be to reveal the influence of RSV infection on the perioperative condition of patients and the expediency of passive imunoprophylaxis with palivizumab. Key words: respiratory syncytial virus, congenital heart disease, imunoprophylaxis

scholarly journals COVID-19 and Children with Congenital Heart Disease: Pandemic Implication

2021 ◽  
Vol 36 (2) ◽  
pp. 138-145
Author(s):  
Mohammad Abdullah Al Mamun ◽  
Manzoor Hussain ◽  
Rezoana Rima
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Pediatric Population ◽  
Severe Infection ◽  
Complex Congenital Heart Disease ◽  
Adult Men ◽  
Cardiovascular Comorbidities ◽  
Increased Risk ◽  
Syncytial Virus

While the global coronavirus crisis worsens, a surprising feature of the disease appears that children might be immune from the worst form of it. Studies suggest that COVID- 19 is more likely to infect older adult men, particularly those with comorbidities. There is only limited data detailing the effects of COVID-19 on the pediatric population. Patients with underlying cardiovascular comorbidities are at increased risk of morbidity and mortality from SARS-CoV-2 infection. Certain adult patients with congenital heart disease (ACHD) and with complex congenital heart disease can be considered as high risk for complications related to COVID-19 infection on the basis of decreased functional reserve. While no study on COVID-19 has been included paediatric patients with congenital heart disease, it stands to reason that patients with congenital heart disease can be considered at higher risk for complications from COVID-19. Given the increased risk for severe COVID-19 in adults with underlying cardiac disease, there is concern that patients with congenital heart disease (CHD) may likewise be at increased risk for severe infection, as they are known to have higher risk for complications with viral illnesses including respiratory syncytial virus and influenza. DS (Child) H J 2020; 36(2): 138-145

P9-05 Acquired coronary artery fistula after open heart surgery for congenital heart disease

2004 ◽  
Vol 97 ◽  
pp. S64-S65
Author(s):  
Shuenn-Nan Chiu ◽  
Mei-Hwan Wu ◽  
Ming-Tai Lin ◽  
En-Ting Wu ◽  
Jou-Kou Wang ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Coronary Artery Fistula ◽  
Open Heart

Junctional tachycardia in infants and children after open heart surgery for congenital heart disease

1987 ◽  
Vol 59 (12) ◽  
pp. 1216-1218 ◽  
Author(s):  
James W. Grant ◽  
Gerald A. Serwer ◽  
Brenda E. Armstrong ◽  
H.Newland Oldham ◽  
Page A.W. Anderson
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Infants And Children ◽  
Open Heart ◽  
Junctional Tachycardia ◽  
In Infants And Children

scholarly journals Pattern and Clinical Profile of Congenital Heart Disease in A Teaching Hospital

1970 ◽  
Vol 21 (1) ◽  
pp. 58-62 ◽  
Author(s):  
L Shamima Sharmin ◽  
M Azizul Haque ◽  
M Iqbal Bari ◽  
M Ayub Ali
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Hospital Stay ◽  
Congenital Heart ◽  
Growth Failure ◽  
Female Child ◽  
Feeding Problems ◽  
Medical College ◽  
One Year ◽  
A Prospective Study

Objectives: To see the (a) type of congenital heart disease, (b) Clinical presentation of the cases, (c) association with extra-cardiac anomalies and disease, (d) complications of different CHD, (e) outcome of patients during hospital stay. Methodology: it was a prospective study conducted in the department of pediatrics of Rajshahi Medical College & Hospital over a period of one year.115 children from birth to 12 years of age who had congenital heart disease confirmed by echocardiography were included. All patients were treated conservatively and observed for immediate out come during the hospital stay. Result: major types of CHD were VSD (42.6%), TOF (18.3%), ASD (14.8%), PDA (7.8%). Male outnumbers female child. Common symptoms were breathlessness (60%), fatigue (54.8%), cough (43.5%), poor weight gain (41.7%), recurrent chest infection (34.8%), fever (28.7%), feeding problems (26.1%), palpitation (21.7%) and bluish discoloration of lips and fingertips (20%). Murmur with or without thrill and cardiomegaly was the most important cardiac finding. Frequently observed complications were heart failure, pulmonary hypertension and growth failure.   doi: 10.3329/taj.v21i1.3221 TAJ 2008; 21(1): 58-62

scholarly journals LVNC – A review

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Lisa Brandon ◽  
◽  
Brian Kerr ◽  
Ken McDonald ◽  
◽  
...  
Keyword(s):  
Heart Failure ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Gold Standard ◽  
Congenital Heart ◽  
Imaging Techniques ◽  
Disease Modifying Therapies ◽  
Increased Risk ◽  
Disease Modifying ◽  
No Gold Standard

LVNC is a relatively new clinical entity, with a significant increase in awareness and diagnosis in recent years. Currently the aetiology and pathogenesis of LVNC remains uncertain, alongside prevalence, however the diagnosis of LVNC appears to be increasing with improving imaging techniques. For educational purposes involving a rare clinical condition, we present the case of a 52 year old gentleman who was diagnosed with LV non compaction via ECHO and CMR. Interestingly it was noted two of his children had congenital heart disease, one daughter had Tetralogy of Fallot, and a second daughter had both an ASD and VSD. Challenges facing LVNC involve difficulty of diagnosis with no gold standard yet available, uncertainty of benefit with standard disease modifying therapies for HF-REF, and apparent increased risk of arrhythmias suggesting early ICD placement may be warranted for patients. Keywords: Hr-Ref; heart failure; lv non compaction; arrhythmias; lcd Risk.

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