scholarly journals Cisplatin, environmental metals, and cardiovascular disease: an urgent need to understand underlying mechanisms

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Suparna C. Clasen ◽  
Paul C. Dinh ◽  
Lifang Hou ◽  
Chunkit Fung ◽  
Howard D. Sesso ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Cardiovascular Effects ◽  
Epidemiologic Studies ◽  
Future Research ◽  
Metal Contaminants ◽  
Vascular Toxicity ◽  
Underlying Mechanisms ◽  
Testicular Cancer Survivors

AbstractSignificantly increased risks of cardiovascular disease occur in testicular cancer survivors given cisplatin-based chemotherapy. The postulated mechanism of platinum-based chemotherapy’s vascular toxicity has been thought secondary to its different early- and late- effects on vascular injury, endothelial dysfunction, and induction of a hypercoagulable state. We highlight for the first time the similarities between platinum-associated vascular adverse events and the vascular toxicity associated with other xenobiotic-metal contaminants. The vascular toxicity seen in large epidemiologic studies of testicular cancer survivors may in part be similar and mechanistically linked to the risk seen in environmental heavy metal contaminants linked to cardiovascular disease. Future research should be directed to better understand the magnitude of the adverse cardiovascular effects of platinum and to elucidate the underlying mechanisms of action.

Early changes in renal function and late cardiovascular disease risk in testicular cancer survivors with 25 years follow-up.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 4541-4541
Author(s):  
Sjoukje Lubberts ◽  
Joost A.B. Kampman ◽  
Hink Boer ◽  
Coby Meijer ◽  
Gerjan J. Navis ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Renal Function ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Testicular Cancer Survivors

scholarly journals Predicting Cardiovascular Disease Among Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy: Application of the Framingham Risk Score

2018 ◽  
Vol 16 (4) ◽  
pp. e761-e769 ◽  
Author(s):  
Darren R. Feldman ◽  
Shirin Ardeshir-Rouhani-Fard ◽  
Patrick Monahan ◽  
Howard D. Sesso ◽  
Chunkit Fung ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Framingham Risk ◽  
Testicular Cancer Survivors

scholarly journals Toxicities Associated with Cisplatin-Based Chemotherapy and Radiotherapy in Long-Term Testicular Cancer Survivors

2018 ◽  
Vol 2018 ◽  
pp. 1-20 ◽  
Author(s):  
Chunkit Fung ◽  
Paul Dinh ◽  
Shirin Ardeshir-Rouhani-Fard ◽  
Kerry Schaffer ◽  
Sophie D. Fossa ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Current Status ◽  
Malignant Neoplasms ◽  
Targeted Prevention ◽  
Care Providers ◽  
National Guidelines ◽  
Testicular Cancer Survivors

Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro- and ototoxicity, pulmonary complications, nephrotoxicity, hypogonadism, infertility, and avascular necrosis. Future research efforts should focus on delineation of the genetic underpinning of these long-term toxicities to understand their biologic basis and etiopathogenetic pathways, with the goal of developing targeted prevention and intervention strategies to optimize risk-based care and minimize chronic morbidities. In the interim, health care providers should advise TCS to adhere to national guidelines for the management of cardiovascular disease risk factors, as well as to adopt behaviors consistent with a healthy lifestyle, including smoking cessation, a balanced diet, and a moderate to vigorous intensity exercise program. TCS should also follow national guidelines for cancer screening as currently applied to the general population.

Impact of long-term serum platinum on neuro- and ototoxicity, cardiovascular disease, and hypogonadism in testicular cancer survivors.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 4518-4518
Author(s):  
Line veronika Hjelle ◽  
Roy M. Bremnes ◽  
per Ole Gundersen ◽  
Mette Sprauten ◽  
Marianne Brydoy ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Testicular Cancer Survivors

scholarly journals Psychological Needs Satisfaction, Self-Rated Health and the Mediating Role of Exercise Among Testicular Cancer Survivors

2021 ◽  
Vol 15 (2) ◽  
pp. 155798832110126
Author(s):  
Anika R. Petrella ◽  
Catherine M. Sabiston ◽  
Madison F. Vani ◽  
Andrew Matthew ◽  
Daniel Santa Mina
Keyword(s):  
Mental Health ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Psychological Needs ◽  
Basic Psychological Needs ◽  
Exercise Behavior ◽  
Physical And Mental Health ◽  
Self Rated Health ◽  
Needs Satisfaction ◽  
Testicular Cancer Survivors

Exploring tenets of basic psychological needs theory, the objective of this study was to examine the association between psychological needs satisfaction, exercise behavior, and physical and mental health among testicular cancer survivors. The present study investigated whether psychological needs satisfaction was directly associated with increased self-rated health, and if this relationship was mediated by engagement in exercise. Testicular cancer survivors ( N = 135; Mage = 32.45; SD = 7.63) self-reported current psychological needs satisfaction, exercise behavior, and perceived global physical and mental health during routine oncology visits. Associations were examined using path analysis. Psychological needs satisfaction was a positive correlate of both self-rated physical and mental health in this sample, and exercise mediated the association between needs satisfaction and self-rated physical health. This study supports the assumptions underpinning basic psychological needs theory in this unique clinical population. Based on the findings, exercise engagement represents one mechanism associated with perceived health after cancer. Supportive care interventions should aim to enhance satisfaction of psychological needs and investigate exercise as a mechanism underpinning the relationship between needs satisfaction and perceived health in testicular cancer survivors.

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