scholarly journals BOMET-QoL-10 questionnaire for breast cancer patients with bone metastasis: the prospective MABOMET GEICAM study

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
A. Barnadas ◽  
◽  
M. Muñoz ◽  
M. Margelí ◽  
J. I. Chacón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Health Status ◽  
Bone Metastasis ◽  
Assessment Tool ◽  
Metastatic Breast ◽  
Perceived Health ◽  
Perceived Health Status ◽  
Patient Reported

Abstract Background Bone metastasis (BM) is the most common site of disease in metastatic breast cancer (MBC) patients. BM impacts health-related quality of life (HRQoL). We tested prospectively the psychometric properties of the Bone Metastasis Quality of Life (BOMET-QoL-10) measure on MBC patients with BM. Methods Patients completed the BOMET-QoL-10 questionnaire, the Visual Analogue Scale (VAS) for pain, and a self-perceived health status item at baseline and at follow-up visits. We performed psychometric tests and calculated the effect size of specific BM treatment on patients´ HRQoL. Results Almost 70% of the 172 patients reported symptoms, 23.3% experienced irruptive pain, and over half were receiving chemotherapy. BOMET-QoL-10 proved to be a quick assessment tool performing well in readability and completion time (about 10 min) with 0–1.2% of missing/invalid data. Although BOMET-QoL-10 scores remained fairly stable during study visits, differences were observed for patient subgroups (e.g., with or without skeletal-related events or adverse effects). Scores were significantly correlated with physician-reported patient status, patient-reported pain, symptoms, and perceived health status. BOMET-QoL-10 scores also varied prospectively according to changes in pain intensity. Conclusions BOMET-QoL-10 performed well as a brief, easy-to-administer, useful, and sensitive HRQoL measure for potential use for clinical practice with MBC patients. Trial registration NCT03847220. Retrospectively registered on clinicaltrials.gov (February the 20th 2019).

scholarly journals PRECYCLE: Multicenter, Randomized Phase IV Intergroup Trial to Evaluate the Impact of E Health-Based Patient Reported Outcome (PRO) Assessment on Quality of Life in Patients with Hormone Receptor Positive, HER2 Negative Locally Advanced or Metastatic Breast Cancer Treated with Palbociclib and an Aromatase Inhibitor- or Palbociclib and Fulvestrant

2021 ◽  
Author(s):  
Tom Degenhardt ◽  
Peter A. Fasching ◽  
Diana Lüftner ◽  
Volkmar Müller ◽  
Christoph Thomssen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Overall Survival ◽  
Metastatic Breast ◽  
Progression Free Survival ◽  
Patient Reported Outcome ◽  
Free Survival ◽  
Hormone Receptor Positive ◽  
Patient Reported

Abstract Background: Efficacy and quality of life (QoL) are key when selecting a therapy for metastatic breast cancer (MBC) patients. In hormone receptor positive (HR+) human epidermal growth factor receptor 2 minus (HER2-) MBC, addition of targeted oral agents such as everolimus or a cycline-dependent kinase 4/6 (CDK 4/6) inhibitor (e.g. palbociclib, ribociclib, abemaciclib) to endocrine therapy substantially prolongs progression-free survival and in the case of a CDK 4/6i also overall survival. Prerequiste for obtaining such benefit is adherence to therapy over the whole treatment duration. Adherence, maintaining patients’ satisfaction, early detection and management of side effects have thus become important challenges, in particular with these new oral drugs and new ways of continuous support for oncological patients are needed. An eHealth-based platform can help to support therapy management and physician-patient interaction.Methods: PreCycle is a multicenter, randomized, phase IV trial in HR+ HER2+ MBC. All patients (n=960) receive the CDK 4/6 inhibitor palbociclib either in first (62.5%) or later line (37.5%) together with endocrine therapy (AI, fulvestrant) according to national guidelines. PreCycle evaluates the time to deterioration (TTD) of QoL in patients supported by eHealth systems with substantially different functionality: CANKADO active vs. inform. CANKADO active is the fully functional CANKADO-based eHealth treatment support system. CANKADO inform is a CANKADO-based eHealth service with a personal login, documentation of daily drug intake, but no further functions. To evaluate QoL, the FACT-B questionnaire is completed at every visit. As little is known about relationships between behavior (e.g. adherence), genetic background, and drug efficacy, the trial includes both patient reported outcome and biomarker screening for discovery of forecast models for adherence, symptoms, QoL, progression free survival (PFS), and overall survival (OS).Discussion: The primary objective of PreCycle is to test the hypothesis of superiority for time to deterioration (TTD) in terms of DQoL = “Deterioration of quality of life” (FACT-G scale) in patients supported by an eHealth therapy management system (CANKADO active) versus in patients merely receiving eHealth-based information (CANKADO inform). EudraCT Number: 2016-004191-22

scholarly journals CASP-19 AND THE HEALTH AND SOCIODEMOGRAPHIC VARIABLES OF OLDER ADULTS PARTICIPATING IN FIBRA 80+

2021 ◽  
Author(s):  
Elaine Valias Sodré Pereira ◽  
Carolina Pessoni Garcia ◽  
Maria José D’Elboux
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Health Status ◽  
Perceived Health ◽  
Well Being ◽  
Perceived Health Status ◽  
Sociodemographic Variables

INTRODUCTION: Assessing quality of life in older adults is relevant due to the significant increase in this population. Based on Maslow’s need hierarchy model, CASP-19 is a broad measure of quality of life that focuses on positive aspects of older adults’ lives, regardless of health conditions or other factors. OBJECTIVE: To compare sociodemographic and health variables with quality of life according to CASP-19 scores. METHODOLOGY: Using data from the Frailty in Brazilian Older People (FIBRA 80+) follow-up study, this study included 233 adults aged ≥ 80 years who resided near the University of Campinas (Campinas, SP, Brazil). Sociodemographic variables (gender, age, and perceived social support), health variables (perceived health status and depressive symptoms) and quality of life were evaluated. RESULTS: The participants were predominantly women (69.09%) with a mean age of 83.46 ± 3.7 years. A total of 77.25% rated their health as fair or good, and 79% showed no signs of depression. The mean CASP-19 score was 41.8 ± 2.62 points, which corresponds to better well-being (total scores range from 0 to 57). Among the instrument’s domains, autonomy and pleasure obtained the highest mean scores (11.15 and 11.64 respectively). When comparing these variables with quality of life, social support (p = 0.001), depressive symptoms (p <0.001), and perceived health status (p <0.001) were statistically significant. CONCLUSIONS: Older adults who were satisfied with their social support, presented no depressive symptoms, and who rated their health as good or very good had higher overall quality of life scores.

scholarly journals Quality of life of women with locally advanced or metastatic breast cancer

2020 ◽  
Vol 41 ◽  
Author(s):  
Eunice de Oliveira Lacerda Lima ◽  
Marcelle Miranda da Silva
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Metastatic Breast Cancer ◽  
Health Status ◽  
Global Health ◽  
Locally Advanced ◽  
Metastatic Breast ◽  
Global Health Status ◽  
The Social

ABSTRACT Objectives: To identify the main affected domains of quality of life of hospitalized women with locally advanced or metastatic breast cancer; and to analyze the association between the level of quality of life and stage of cancer. Method: This was a cross-sectional quantitative, study conducted in Rio de Janeiro, Brazil, between March and July 2017. Interviews were performed with 199 women. The researchers administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, with analysis using the Statistical Package for the Social Sciences software and the Kruskal-Wallis test. Results: Mean global health status was 32.04. On the functional scales, cognitive functioning scored the highest (60.47), while role functioning scored the lowest (12.48). Fatigue presented the highest mean (69.57). The scores for global health status and the functional scales (with the exception of the social functioning) decreased as staging progressed. Conclusion: The stage of cancer affects the quality of life of the studied sample of women.

Sign in / Sign up

Export Citation Format

Share Document