scholarly journals Effect of bryostatin-1 as an anthelmintic drug on adult Syphacia muris infection in rats

2017 ◽  
Vol 78 (1) ◽  
Author(s):  
Samar Fouad Harras ◽  
Mohamed Hassan Mona ◽  
Aisha Gadafi Abdalla ◽  
Elsayed Ibrahim Salim
Keyword(s):  
Bryostatin 1 ◽  
Anthelmintic Drug ◽  
Syphacia Muris

Syphacia muris infection in rats attenuates colorectal carcinogenesis through oxidative stress and gene expression alterations. Implications for modulatory effects by Bryostatin-1

2018 ◽  
Vol 63 (1) ◽  
pp. 198-209 ◽  
Author(s):  
Elsayed I. Salim ◽  
Samar F. Harras ◽  
Aisha G. Abdalla ◽  
Mohmmed H. Mona
Keyword(s):  
Oxidative Stress ◽  
Cellular Proliferation ◽  
Significant Inhibition ◽  
Aberrant Crypt Foci ◽  
Colorectal Carcinogenesis ◽  
Oxidative Stress Markers ◽  
Bryostatin 1 ◽  
Stress Markers ◽  
Syphacia Muris ◽  
Cox 2

Abstract Accumulating evidence suggest that some infectious agents may interfere in the natural progression of neoplasia. This study examined the association between chronic infection with adult Syphacia muris parasites and 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis in rats. In addition, the conceivable therapeutic effect of Bryostatin-1, a potent extract of the marine Bryozoan, Bugulane ritina, was investigated against this combined effect.DMH administration has induced aberrant crypt foci (ACF), surrogate biomarkers for colorectal carcinogenesis, while the S. muris infection combined with DMH has significantly increased the total numbers of ACF. Nonetheless, treatment with Bryostatin-1 after infection has significantly reduced the ACF numbers particularly larger ones. This inhibition was concomitant with significant inhibition in the immunohistochemical levels of the ki67, Caspase-3 and IgM levels in colorectal epithelium, as well as serum levels of IgM and IgG. Additionally, treatment with Bryostatin-1 after S. muris + DMH has modulated enzymatic antioxidative markers levels of superoxide dismutase and catalase as well as the non-enzymatic antioxidant markers levels of reduced glutathione, lipid peroxidation, nitric oxide and total antioxidant capacity. Further, treatment with Bryostatin-1 has down-regulated the mRNA expression levels of COX-2 and APC genes in colorectal mucosa. In conclusion, infection with S. muris during colorectal carcinogenesis has significantly modulated the oxidative stress markers in the colorectum, while treatment with Bryostatin-1 has exerted significant curative potential. A mechanism could be explained that Bryostatin-1 treatment has reduced oxidative stress markers activities along with affecting host to parasite immunity possibly leading to changes in the COX-2 and APC expression, retarding cellular proliferation and subsequently reducing the colorectal carcinogenesis events.

Phase II evaluation of bryostatin-1 in metastatic melanoma

2001 ◽  
Vol 11 (2) ◽  
pp. 183-188 ◽  
Author(s):  
A. Y. Bedikian ◽  
C. Plager ◽  
J. R. Stewart ◽  
C. A. O'Brian ◽  
S. K. Herdman ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Phase Ii ◽  
Bryostatin 1

ChemInform Abstract: Total Synthesis of Bryostatin 1: A Short Route

ChemInform ◽  
2012 ◽  
Vol 43 (5) ◽  
pp. no-no
Author(s):  
Soraya Manaviazar ◽  
Karl J. Hale
Keyword(s):  
Total Synthesis ◽  
Bryostatin 1 ◽  
Short Route

scholarly journals Sanitary profile in mice and rat colonies in laboratory animal houses in Minas Gerais: I - Endo and ectoparasites

2007 ◽  
Vol 59 (6) ◽  
pp. 1478-1484 ◽  
Author(s):  
K.A. Bicalho ◽  
F.T.M. Araújo ◽  
R.S. Rocha ◽  
O.S. Carvalho
Keyword(s):  
Physical Environment ◽  
Minas Gerais ◽  
Public Institutions ◽  
Hymenolepis Nana ◽  
Syphacia Muris ◽  
Syphacia Obvelata ◽  
Animal House ◽  
Aspiculuris Tetraptera ◽  
Giardia Muris ◽  
Sanitary Conditions

The sanitary conditions of 13 animal houses in nine public institutions in Minas Gerais, and the presence of endo and ectoparasites of mice and rats colonies kept in these facilities were evaluated. Data about barriers to prevent the transmission of diseases and a program of sanitary monitoring were obtained through a questionnaire and local visit. Parasitological methods were performed for diagnosing mite, lice, helminthes, and protozoa parasites in 344 mice and 111 rats. Data have shown that the majority of the animal houses had neither proper physical environment nor protection barriers to prevent the transmission of infections. Parasitological results have shown that only one animal house (7.7%) had parasite free animals, whereas the others have presented infected animals and the prevalences of parasites in the mice colonies were: Myobia musculi (23.1%); Myocoptes musculinus (38.5%); Radfordia affinis (15.4%); Syphacia obvelata (92.3%); Aspiculuris tetraptera (23.1%); Hymenolepis nana (15.4%); Spironucleus muris (46.2%); Giardia muris (46.2%); Tritrichomonas muris (53.8%); Trichomonas minuta (61.5%); Hexamastix muris (7.7%); and Entamoeba muris (84.6%). As for the rat colonies, the prevalences were: Poliplax spinulosa (8.1%); Syphacia muris (46.2%); Trichosomoides crassicauda (28.6%); Spironucleus muris (85.7%); Tritrichomonas muris (85.7%); Trichomonas minuta (85.7%); Hexamastix muris (14.3%) and Entamoeba muris (85.7%).

Monepantel: the most studied new anthelmintic drug of recent years

Parasitology ◽  
2014 ◽  
Vol 141 (13) ◽  
pp. 1686-1698 ◽  
Author(s):  
L. LECOVÁ ◽  
L. STUCHLÍKOVÁ ◽  
L. PRCHAL ◽  
L. SKÁLOVÁ
Keyword(s):  
Mode Of Action ◽  
Aquatic Organisms ◽  
Similar Efficacy ◽  
Gastrointestinal Nematodes ◽  
Soil Microflora ◽  
Parent Molecule ◽  
Important Species ◽  
Anthelmintic Drug ◽  
Reported Data ◽  
Molecular Mode

SUMMARYMonepantel (MOP), a new anthelmintic drug from a group of amino-acetonitrile derivatives, has been intensively studied during last years. Many authors examined this new drug from different perspectives, e.g. efficacy against different species and stages of parasites, mode of action, metabolism, pharmacokinetics, toxicity, resistance, ecotoxicity, etc. MOP is an anthelmintic for livestock (currently only sheep and goats), with molecular mode of action which is different to all other anthelmintics. MOP has a broad-spectrum of activity against gastrointestinal nematodes of sheep, including adults and L4 larvae of the most important species. The key feature of MOP is its full effectiveness against strains of nematodes resistant to benzimidazoles, levamisole, macrocyclic lactones and closantel. After oral administration, MOP is quickly absorbed into the bloodstream and quickly metabolized to MOP sulfone that has a similar efficacy as the parent molecule. Several other MOP metabolites formed in ovine hepatocytes were described. MOP and its metabolites are considered to be non-toxic to environment and its components, such as soil microflora, aquatic organisms, dung organisms, vegetation, etc. The aim of the presented review was not to collect all reported data but to bring an overview of various approaches in the study of MOP and to evaluate their principal results.

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