scholarly journals Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Doo-Wan Cho ◽  
Hyoung-Yun Han ◽  
Mi-Jin Yang ◽  
Dong Ho Woo ◽  
Su-Cheol Han ◽  
...  
Keyword(s):  
Cynomolgus Monkey ◽  
Macaca Fascicularis ◽  
Clinical Signs ◽  
Experimental Period ◽  
Serum Biochemistry ◽  
Surgical Removal ◽  
Telemetry System ◽  
Observation Study ◽  
The Status ◽  
Conscious Animals

Abstract Background Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals are either used for other studies or euthanatized. Case presentation Herein, we report the case of a living cynomolgus monkey (Macaca fascicularis) that was used for the entire experimental period, instead of euthanasia, after surgical removal of an implanted telemetry system. Radiography was used to determine the status of the implanted telemetry, following which, a repair surgery was performed for removing the system; clinical signs were used to preserve the life of the cynomolgus monkey. Postoperative clinical signs, food consumption, hematology, and serum biochemistry were examined during the 12-month observational period. No abnormal readings or conditions were observed in the subject after implant removal. Conclusions This study may be a useful case report for living cynomolgus monkeys in telemetry implantations used throughout the study period. We suggest minimizing the suffering and improving the welfare of these animals.

scholarly journals Identification of Chromosome 17 Trisomy in a Cynomolgus Monkey (Macaca fascicularis) by Multicolor FISH Techniques

2021 ◽  
pp. 1-6
Author(s):  
Aoi Kimura ◽  
Satowa Yahashi ◽  
Fumio Chatani ◽  
Hideyuki Tanabe
Keyword(s):  
Cynomolgus Monkey ◽  
Macaca Fascicularis ◽  
Extra Chromosome ◽  
Clinical Signs ◽  
Trisomy 13 ◽  
Abnormal Behavior ◽  
Chromosome 17 ◽  
Multicolor Fish ◽  
Metaphase Chromosomes ◽  
Patau Syndrome

A female cynomolgus monkey (<i>Macaca fascicularis</i>) with facial features characteristic of Down syndrome showed abnormal behavior, unwariness toward humans, and poor concentration. The number of metaphase chromosomes in blood lymphocytes was examined and found to be 43, which indicated one extra chromosome to the normal diploid number (2n = 42). We then used Q-banding and multicolor FISH techniques to identify the extra chromosome. The results revealed an additional chromosome 17, with no other chromosomal rearrangements, such as translocations. Since no mosaicism or heterozygous variant chromosomes were observed, full trisomy 17 was assessed in this female cynomolgus monkey. Chromosome 17 corresponds to human chromosome 13, and human trisomy 13, known as Patau syndrome, results in severe clinical signs and, often, a short life span; however, this individual has reached an age of 10 years with only mild clinical signs. Although genomic differences exist between human and macaques, this individual’s case could help to reveal the pathological and genetic mechanisms of Patau syndrome.

scholarly journals Identification of Risk Factors for Lameness Detection with Help of Biosensors

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 610
Author(s):  
Ramūnas Antanaitis ◽  
Vida Juozaitienė ◽  
Gediminas Urbonavičius ◽  
Dovilė Malašauskienė ◽  
Mindaugas Televičius ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Milk Fat ◽  
Milk Protein ◽  
Standard Procedure ◽  
Clinical Signs ◽  
Experimental Period ◽  
Early Lactation ◽  
Protein Ratio ◽  
Walking Activity ◽  
Protein Milk

In this study we hypothesized that the lameness of early lactation dairy cows would have an impact on inline biomarkers, such as rumination time (RT), milk fat (%), milk protein (%), milk fat/protein ratio (F/P), milk lactose (L, %), milk electrical conductivity of all udder quarters, body weight (BW), temperature of reticulorumen content (TRR), pH of reticulorumen content (pH), and walking activity (activity). All 30 lame cows (LCs) used in this experiment had a score of 3–4, identified according to the standard procedure of Sprecher et al.. The 30 healthy cows (HC) showed a lameness score of one. RT, milk fat, MY, milk protein, F/P, L, milk electrical conductivity of all udder quarters, and BW were registered using Lely Astronaut® A3 milking robots each time the cow was being milked. The TRR, cow activity, and pH of the contents of each cow’s reticulorumen were registered using specific smaXtec boluses. The study lasted a total of 28 days. Days “−14” to “−1” denote the days of the experimental period before the onset of clinical signs of lameness (day “0”), and days “1” to “13” indicate the period after the start of treatment. We found that from the ninth day before the diagnosis of laminitis until the end of our study, LCs had higher milk electrical conductivity in all udder quarters, and higher milk fat to protein ratios. On the 3rd day before the onset of clinical signs of the disease until the day of diagnosis, the milk fat of the LC group was reduced. The activity of the LCs decreased sharply from the second day to the first day after treatment. RT in the HC group tended to decrease during the experiment. pH in LCs also increased on the day of the appearance of clinical signs.

Oxytocin in the Corpus Luteum of the Cynomolgus Monkey (Macaca fascicularis)

Endocrinology ◽  
1984 ◽  
Vol 115 (2) ◽  
pp. 570-574 ◽  
Author(s):  
FIRYAL S. KHAN-DAWOOD ◽  
EDWARD L. MARUT ◽  
M. YUSOFF DAWOOD
Keyword(s):  
Corpus Luteum ◽  
Cynomolgus Monkey ◽  
Macaca Fascicularis

scholarly journals Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Phoneutria nigriventer Spider Venom

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 531 ◽  
Author(s):  
Eliane Dallegrave ◽  
Eliane Taschetto ◽  
Mirna Bainy Leal ◽  
Flavia Techera Antunes ◽  
Marcus Gomez ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Relative Weight ◽  
Serum Biochemistry ◽  
Renal Tissue ◽  
Organ Weight ◽  
Female Rats ◽  
Mild Degree ◽  
Physiological Limits ◽  
Voltage Dependent ◽  
Phoneutria Nigriventer

Phα1β, a purified peptide from the venom of the spider Phoneutria nigriventer, and its recombinant form CTK 01512-2 are voltage-dependent calcium channel (CaV) blockers of types N, R, P/Q, and L with a preference for type N. These peptides show analgesic action in different pain models in rats. The aim of this study was to evaluate the acute intrathecal toxicity of the native and recombinant Phα1β toxin in Wistar rats. Clinical signs, serum biochemistry, organ weight, and histopathological alterations were evaluated in male and/or female rats. Dyspnea was observed in males, hyporesponsiveness in females, and Straub tail and tremors in both genders. There were no significant differences in male organ weight, although significant differences in the female relative weight of the adrenal glands and spleen have been observed; these values are within the normal range. Serum biochemical data revealed a significant reduction within the physiological limits of species related to urea, ALT, AST, and FA. Hepatic and renal congestion were observed for toxin groups. In renal tissue, glomerular infiltrates were observed with increased glomerular space. These histological alterations were presented in focal areas and in mild degree. Therefore, Phα1β and CTK 01512-2 presented a good safety profile with transient toxicity clinical signals in doses higher than used to obtain the analgesic effect.

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