scholarly journals Emerging functional materials based on chemically designed molecular recognition

BMC Materials ◽  
2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Wei Chen ◽  
Xiaohua Tian ◽  
Wenbo He ◽  
Jianwei Li ◽  
Yonghai Feng ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Material Science ◽  
Rational Design ◽  
Dynamic Properties ◽  
Functional Materials ◽  
Molecular Assembly ◽  
Modern Material ◽  
Chemical Recognition ◽  
Fundamental Research ◽  
Modern Material Science

AbstractThe specific interactions responsible for molecular recognition play a crucial role in the fundamental functions of biological systems. Mimicking these interactions remains one of the overriding challenges for advances in both fundamental research in biochemistry and applications in material science. However, current molecular recognition systems based on host–guest supramolecular chemistry rely on familiar platforms (e.g., cyclodextrins, crown ethers, cucurbiturils, calixarenes, etc.) for orienting functionality. These platforms limit the opportunity for diversification of function, especially considering the vast demands in modern material science. Rational design of novel receptor-like systems for both biological and chemical recognition is important for the development of diverse functional materials. In this review, we focus on recent progress in chemically designed molecular recognition and their applications in material science. After a brief introduction to representative strategies, we describe selected advances in these emerging fields. The developed functional materials with dynamic properties including molecular assembly, enzyme-like and bio-recognition abilities are highlighted. We have also selected materials with dynamic properties in contract to traditional supramolecular host–guest systems. Finally, the current limitations and some future trends of these systems are discussed.

Antimicrobial Activities of Metal Containing Compounds and Hybrids

2020 ◽  
Vol 26 (45) ◽  
pp. 5881-5891
Author(s):  
Tahseen Kamal ◽  
Sher Bahadar Khan ◽  
Abdullah M. Asiri
Keyword(s):  
Growth Inhibition ◽  
Mode Of Action ◽  
Material Science ◽  
Antimicrobial Activities ◽  
Excellent Performance ◽  
Modern Material ◽  
Modern Material Science

Normally, antibiotics are used for the growth inhibition of a variety of pathogens. The ever- increasing resistance of the various disease-causing pathogens to the antibiotics has drawn tremendous attention of researchers to find efficient alternatives. The recent era of modern material science and nanotechnology has made it possible to replace the existing antibiotics up to some extent. Currently, a vast library of materials has been prepared, which shows excellent performance against pathogens. Such materials consist of certain metals. Through this review, we present some notable studies concerning the antimicrobial activities of various metal containing compounds and their mode of action.

scholarly journals Hyperelastic Bone Involving the Washer Method

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Kristin Jones ◽  
Keyword(s):  
3D Printing ◽  
Material Science ◽  
Medical Equipment ◽  
Cost Comparison ◽  
Modern Material ◽  
The Creation ◽  
The Cost ◽  
Modern Material Science

The research conducted focuses on 3D printing and its application in medical equipment. A recent breakthrough in modern material science was made with the creation of hyperelastic bone. This exploration looks at how hyperelastic bone is created, the cost comparison to older tools, and the possible design for hyperelastic bone. Detailed calculations and descriptions are also included to explain the reasoning behind the work conducted.

scholarly journals Case Study of Polyvinylidene Fluoride Doping by Carbon Nanotubes

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1428
Author(s):  
Pavel Kaspar ◽  
Dinara Sobola ◽  
Klára Částková ◽  
Rashid Dallaev ◽  
Eva Šťastná ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Material Science ◽  
Polyvinylidene Fluoride ◽  
Fiber Composites ◽  
Point Of View ◽  
Modern Material ◽  
Fluoride Fiber ◽  
Fluoride Doping ◽  
Modern Material Science

Modern material science often makes use of polyvinylidene fluoride thin films because of various properties, like a high thermal and chemical stability, or a ferroelectric, pyroelectric and piezoelectric activity. Fibers of this polymer material are, on the other hand, much less explored due to various issues presented by the fibrous form. By introducing carbon nanotubes via electrospinning, it is possible to affect the chemical and electrical properties of the resulting composite. In the case of this paper, the focus was on the further improvement of interesting polyvinylidene fluoride properties by incorporating carbon nanotubes, such as changing the concentration of crystalline phases and the resulting increase of the dielectric constant and conductivity. These changes in properties have been explored by several methods that focused on a structural, chemical and electrical point of view. The resulting obtained data have been documented to create a basis for further research and to increase the overall understanding of the properties and usability of polyvinylidene fluoride fiber composites.

scholarly journals Stability and Robustness of Unbalanced Genetic Toggle Switches in the Presence of Scarce Resources

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 271
Author(s):  
Chentao Yong ◽  
Andras Gyorgy
Keyword(s):  
Cell Fate ◽  
Rational Design ◽  
Resource Competition ◽  
Dynamic Properties ◽  
Mechanistic Model ◽  
Robustness Analysis ◽  
System Level ◽  
Genetic Circuits ◽  
Scarce Resources ◽  
Genetic Systems

While the vision of synthetic biology is to create complex genetic systems in a rational fashion, system-level behaviors are often perplexing due to the context-dependent dynamics of modules. One major source of context-dependence emerges due to the limited availability of shared resources, coupling the behavior of disconnected components. Motivated by the ubiquitous role of toggle switches in genetic circuits ranging from controlling cell fate differentiation to optimizing cellular performance, here we reveal how their fundamental dynamic properties are affected by competition for scarce resources. Combining a mechanistic model with nullcline-based stability analysis and potential landscape-based robustness analysis, we uncover not only the detrimental impacts of resource competition, but also how the unbalancedness of the switch further exacerbates them. While in general both of these factors undermine the performance of the switch (by pushing the dynamics toward monostability and increased sensitivity to noise), we also demonstrate that some of the unwanted effects can be alleviated by strategically optimized resource competition. Our results provide explicit guidelines for the context-aware rational design of toggle switches to mitigate our reliance on lengthy and expensive trial-and-error processes, and can be seamlessly integrated into the computer-aided synthesis of complex genetic systems.

scholarly journals Rational Design of a Cytotoxic Dinuclear Cu2Complex That Binds by Molecular Recognition at Two Neighboring Phosphates of the DNA Backbone

2015 ◽  
Vol 54 (6) ◽  
pp. 2679-2690 ◽  
Author(s):  
Thomas Jany ◽  
Alexander Moreth ◽  
Claudia Gruschka ◽  
Andy Sischka ◽  
Andre Spiering ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Rational Design ◽  
Dna Backbone

scholarly journals Rational design of functional materials guided by single particle chemiluminescence imaging

2019 ◽  
Vol 10 (21) ◽  
pp. 5444-5451 ◽  
Author(s):  
Weijun Kong ◽  
Qi Li ◽  
Wei Wang ◽  
Xiaoning Zhao ◽  
Shenglong Jiang ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Single Particle ◽  
Rational Design ◽  
Functional Materials ◽  
Single Particles ◽  
Improved Performance

Correlated chemiluminescence imaging and structural characterization of single particles helped the rational design of functional materials with significantly improved performance.

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