Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

Myelosuppression by doxorubicin is a life-threatening adverse effect in cancer patients undergoing chemotherapy. Methyl gallate is an antioxidant found in a variety of plant species. The study aimed to demonstrate the protective role of methyl gallate on doxorubicin-induced cytopenias in Wistar rats. The animals were prophylactically treated with two different doses of methyl gallate (150mg/kg/day and 300mg/kg/day) orally for seven days. Doxorubicin (25mg/kg; single dose) was administered through intraperitoneal route on the seventh day to induce cytopenias. Blood was collected 24 hours after the administration of doxorubicin and complete blood counts were estimated. There was significant (p≤0.05) development of peripheral cytopenias in doxorubicin treated control rats compared to normal saline treated control rats. Methyl gallate at both the doses significantly (p≤0.05) mitigated doxorubicin induced cytopenias compared to doxorubicin treated control rats. The findings of the present study revealed that methyl gallate has protective role in doxorubicin-induced cytopenias in Wistar rats. Following clinical studies, methyl gallate may serve as a viable alternative to growth factors in patients undergoing chemotherapy.

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The Possible Protective Role of Sesame Oil on Skeletal Muscle Regeneration in Induced Red-Bull Injury: Experimental Study

Journal of Medical Histology ◽

10.21608/jmh.2019.16388.1065 ◽

2019 ◽

Vol 3 (2) ◽

pp. 216-224

Author(s):

Amany Hamoud ◽

Rasha Radwan

Keyword(s):

Skeletal Muscle ◽

Experimental Study ◽

Muscle Regeneration ◽

Protective Role ◽

Sesame Oil ◽

Skeletal Muscle Regeneration ◽

Red Bull

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Protective role of peroxiredoxin-4 in heart failure

Clinical Science ◽

10.1042/cs20191072 ◽

2020 ◽

Vol 134 (1) ◽

pp. 71-72

Author(s):

Naseer Ahmed ◽

Masooma Naseem ◽

Javeria Farooq

Keyword(s):

Heart Failure ◽

Cardiac Fibroblasts ◽

Protective Role ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Total Antioxidant ◽

Galectin 3 ◽

Consequent Increase ◽

And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

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Parenting Behaviors and Anxiety in Young Adults

Journal of Individual Differences ◽

10.1027/1614-0001/a000169 ◽

2015 ◽

Vol 36 (3) ◽

pp. 170-176 ◽

Cited By ~ 5

Author(s):

Erin N. Stevens ◽

Joseph R. Bardeen ◽

Kyle W. Murdock

Keyword(s):

Effortful Control ◽

Parenting Behaviors ◽

Protective Role ◽

Anxiety Symptoms ◽

Interactive Effects ◽

Parental Overprotection ◽

High Control ◽

Development Of Anxiety ◽

The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

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