scholarly journals Diffuse leptomeningeal glioneuronal tumor with high-grade features masquerading as tubercular meningitis—a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Sameer Peer ◽  
Vivek Murumkar ◽  
Karthik Kulanthaivelu ◽  
Chandrajit Prasad ◽  
Shilpa Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Histopathological Examination ◽  
Glioneuronal Tumor ◽  
Communicating Hydrocephalus ◽  
High Grade ◽  
Endemic Region ◽  
Tubercular Meningitis ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

Abstract Background Diffuse leptomeningeal glioneuronal tumor (DLGNT) has been recently described in the literature. The complete neuroimaging spectrum and histopathological characteristics of this entity are yet to be elucidated. In an endemic region, diffuse leptomeningeal enhancement on neuroimaging with associated communicating hydrocephalus is usually suggestive of infective meningitis and the patients are started on empirical anti-microbial therapy. However, it is important to consider other differential diagnosis of leptomeningeal enhancement in such cases, particularly if the clinical condition does not improve on anti-microbial therapy. An early diagnosis of a neoplastic etiology may be of particular importance as the treatment regimens vary considerably depending on the underlying disease condition. Case presentation In this case report, we describe a case of DLGNT with high-grade histopathological features which was initially managed as tubercular meningitis based on the initial neuroimaging findings. Due to worsening of the clinical course and subsequent imaging findings at follow-up, a diagnosis of DLGNT was considered and subsequently proven to be DLGNT with features of anaplasia on histopathological examination of leptomeningeal biopsy specimen. Conclusion This case highlights the importance of recognizing certain subtle finding on MRI which may help in an early diagnosis of DLGNT which is crucial for appropriate treatment.

scholarly journals A Case of Diffuse Leptomeningeal Glioneuronal Tumor Misdiagnosed as Chronic Tuberculous Meningitis without Brain Biopsy

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Jung koo Lee ◽  
Hak-cheol Ko ◽  
Jin-gyu Choi ◽  
Youn Soo Lee ◽  
Byung-chul Son
Keyword(s):  
Tuberculous Meningitis ◽  
Glioneuronal Tumor ◽  
Communicating Hydrocephalus ◽  
Laboratory Findings ◽  
Cytologic Examination ◽  
Mental Confusion ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor ◽  
The Brain ◽  
Basal Cisterns

Here we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 62-year-old male patient misdiagnosed as having tuberculous meningitis. Due to its rarity and radiologic findings of leptomeningeal enhancement in the basal cisterns on magnetic resonance imaging (MRI) similar to tuberculous meningitis, DLGNT in this patient was initially diagnosed as communicating hydrocephalus from tuberculous meningitis despite absence of laboratory findings of tuberculosis. The patient’s symptoms and signs promptly improved after a ventriculoperitoneal shunting surgery followed by empirical treatment against tuberculosis. Five years later, mental confusion and ataxic gait developed in this patient again despite well-functioning ventriculoperitoneal shunt. Aggravation of leptomeningeal enhancement in the basal cisterns was noted in MRI. An additional course of antituberculosis medication with steroid was started without biopsy of the brain. Laboratory examinations for tuberculosis were negative again. After four months of improvement, his mental confusion, memory impairment, dysphasia, and ataxia gradually worsened. A repeated MRI of the brain showed further aggravation of leptomeningeal enhancement in the basal cisterns. Biopsy of the brain surface and leptomeninges revealed a very rare occurrence of DLGNT. His delayed diagnosis of DLGNT might be due to prevalence of tuberculosis in our country, similarity in MRI finding of prominent leptomeningeal enhancement in the basal cisterns, and extreme rarity of DLGNT in the elderly. DLGLT should be considered in differential diagnosis of medical conditions presenting as communicating hydrocephalus with prominent leptomeningeal enhancement. A timely histologic diagnosis through a leptomeningeal biopsy of the brain and spinal cord in case of unusual leptomeningeal enhancement with uncertain laboratory findings is essential because cytologic examination of the cerebrospinal fluid in DLGNT is known to be negative.

scholarly journals Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child From an Endemic Region

2021 ◽  
Vol 9 ◽  
Author(s):  
Yong Guang Teh ◽  
Nornazirah Azizan ◽  
Nur Atifah Mohd Naim ◽  
Chiak Yot Ng ◽  
Ke Juin Wong ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Who Classification ◽  
World Health ◽  
Glioneuronal Tumor ◽  
High Grade ◽  
Endemic Region ◽  
Case Presentation ◽  
Diffuse Leptomeningeal Glioneuronal Tumor ◽  
Health Organization

Background: Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a new entity described in the 2016 World Health Organization (WHO) classification of brain tumors. While DL-GNT is predominantly an indolent tumor that affects young boys, high-grade DL-GNT is unusual and seldom reported in children.Case Presentation: In this report, we describe the challenges and pitfalls associated with diagnosing this high-grade variant in a tuberculosis-endemic region. We highlight the importance of identifying non-typical imaging findings, i.e., non-enhancing cystic lesions with high T2 signal along the leptomeningeal surface, that may expedite the diagnosis of this condition. Histopathologic correlations with MR spectroscopy findings are also discussed.Conclusion: We provide the first clinical imaging report of utilizing MR spectroscopy to distinguish DL-GNT from tuberculosis with histopathologic correlation.

Tuberculosis of the Gallbladder: An uncommon Case Report

2021 ◽  
Vol 15 (2) ◽  
pp. 106-107
Author(s):  
Swapan Kumar Biswas ◽  
Saiful Islam Khan ◽  
Muhammad Mofazzal Hossain
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Open Cholecystectomy ◽  
Chronic Cholecystitis ◽  
Computed Tomography Scan ◽  
Endemic Region ◽  
Uncommon Case ◽  
Tomography Scan

Isolated gall bladder tuberculosis (GBTB) is exceedingly rare even in an endemic region and is usually found as a GB mass in association with cholelithiasis. Confirmed preoperative diagnosis is very difficult, and most cases are diagnosed after cholecystectomy. We present a case of a 45-years-old woman who came with symptoms of chronic cholecystitis. Computed tomography scan revealed intraluminal gallbladder mass and cholelithiasis. The patient underwent open cholecystectomy and GBTB was diagnosed after histopathological examination. Histopathological examination should be done after all cholecystectomy operations. Faridpur Med. Coll. J. 2020;15(2): 106-107

Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple’s disease: a case report and literature review

2017 ◽  
Vol 33 (8) ◽  
pp. 1411-1414 ◽  
Author(s):  
Vega Karlowee ◽  
Manish Kolakshyapati ◽  
Vishwa Jeet Amatya ◽  
Takeshi Takayasu ◽  
Ryo Nosaka ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Glioneuronal Tumor ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

PRIMARY UNDIFFERENTIATED PLEOMORPHIC SARCOMA OF BREAST IN A 24 YEAR FEMALE : A CASE REPORT

2021 ◽  
pp. 57-58
Author(s):  
Sona Pathak ◽  
Manoj Kumar Paswan ◽  
Arpana ShailalyTirkey ◽  
Joyeeta Mandal
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Histopathological Examination ◽  
Axillary Lymph ◽  
High Grade ◽  
Node Dissection ◽  
Total Mastectomy ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Adolescents And Adults

Undifferentiated pleomorphic sarcoma constitutes less than 5 % of all sarcomas in adults and has been rarely seen in the breast and is dened as a group of pleomorphic, high-grade sarcomas in which any attempt to disclose their line of differentiation has failed . Most undifferentiated pleomorphic sarcomas(UPS) have occurred in their sixth and seventh decades of life and very rarely in adolescents and adults. We report a case of 24 year old female presented with painless lump in right breast and rapidly increasing in size for last 5 months. Iinitial diagnosis was made as sarcoma breast on the basis of physical and radiological examination. After that total mastectomy was done without axillary lymph node dissection, as lymphatic spread is very rare. But without histopathological examination and most importantly IHC-panel, it is impossible to make a denitive diagnosis of UPS breast.

Unusual high-grade features in pediatric diffuse leptomeningeal glioneuronal tumor: comparison with a typical low-grade example

2017 ◽  
Vol 70 ◽  
pp. 105-112 ◽  
Author(s):  
Katherine E. Schwetye ◽  
Akash P. Kansagra ◽  
James McEachern ◽  
Robert E. Schmidt ◽  
Karen Gauvain ◽  
...  
Keyword(s):  
Glioneuronal Tumor ◽  
Low Grade ◽  
High Grade ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

scholarly journals Dysplasia epiphysealis hemimelica: A case report

2014 ◽  
Vol 71 (11) ◽  
pp. 1081-1084
Author(s):  
Dalibor Jovanovic ◽  
Milena Ilic ◽  
Milos Milosavljevic ◽  
Zorica Mihajlovic ◽  
Radisa Vojinovic ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Ankle Joint ◽  
Developmental Disorder ◽  
Histopathological Examination ◽  
Sporadic Case ◽  
Unknown Etiology ◽  
Histological Findings ◽  
Tarsal Bone ◽  
Dysplasia Epiphysealis Hemimelica

Introduction. Dysplasia epiphysealis hemimelica, also known as Trevor?s disease, is an extremely rare skeletal developmental disorder of unknown etiology, characterized by an osteocartilaginous outgrowth of one or more epiphyses or of a tarsal bone during childhood. Case report. We presented a sporadic case of dysplasia epiphysealis hemimelica developed in the talus. A 6- year-old boy complained of swelling of his right ankle joint, with painful and reduced movements. Radiographies suggested excessive overgrowth of the dorsomedial aspect of the talus. The tumor was surgically excised and the gross and histological findings were consistent with those of osteochondroma. Conclusion. Dysplasia epiphysealis hemimelica is diagnosed by clinical, radiographic and histopathological examination. Early diagnosis is important for the condition to be treated before the deformity becomes disabling.

scholarly journals Diffuse Leptomeningeal Glioneuronal Tumor: Case Report and Review of Literature

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Marianayagam Neelan J ◽  
Ben-Shalom Netanel ◽  
Toledano Helen ◽  
Marglit Nevo ◽  
Michowiz Shalom ◽  
...  
Keyword(s):  
Case Report ◽  
Glioneuronal Tumor ◽  
Review Of Literature ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

scholarly journals Acute Stroke in Tubercular Meningitis: A Case Report

2019 ◽  
Vol 57 (219) ◽  
Author(s):  
Suzit Bhusal ◽  
Sujata Dahal ◽  
Neha Gautam ◽  
Prakash Banjade
Keyword(s):  
Case Report ◽  
Basal Ganglia ◽  
Acute Stroke ◽  
Female Patient ◽  
Internal Capsule ◽  
Communicating Hydrocephalus ◽  
Tubercular Meningitis ◽  
Mortality And Morbidity ◽  
Anterior Thalamus ◽  
Ischemic Infarct

Most of the strokes in tubercular meningitis are multiple, bilateral, and located in the basal ganglia, especially the ‘tubercular zone’, which comprises of the caudate, anterior thalamus, anterior limb, and genu of the internal capsule. These are attributed to the involvement of medial striate, thalamotuberal, and thalamostriate arteries, which are embedded in exudates and likely to be stretched by coexistent hydrocephalus. Corticosteroids with antitubercular therapy were thought to reduce mortality and morbidity but their role in lowering strokes has not been proven. The mechanism of stroke in our case was vasculitis. Here, we are reporting a case of 22-years female patient with tubercular meningitis. She had complications of ischemic infarct and severe communicating hydrocephalus with a seizure disorder.

scholarly journals Diffuse Leptomeningeal Glioneuronal Tumor in an Adult: A Diagnostic Challenge

2022 ◽  
Author(s):  
Mukesh Kumar Bhaskar ◽  
Mukta Meel ◽  
Kusum Mathur ◽  
Arpita Jindal ◽  
Mohit Khandelwal
Keyword(s):  
Imaging Finding ◽  
Magnetic Resonance Imaging Finding ◽  
Delayed Diagnosis ◽  
Glioneuronal Tumor ◽  
Diagnostic Challenge ◽  
Histologic Diagnosis ◽  
Laboratory Findings ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor ◽  
Brain And Spinal Cord

AbstractHere we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 35-year-old man, who was misdiagnosed twice as having tuberculosis meningitis and later racemose neurocysticercosis. His delayed diagnosis of DLGNT might be due to prevalence of tuberculosis in our country, similarity in magnetic resonance imaging finding of prominent leptomeningeal enhancement in different cisterns of brain, and extreme rarity of DLGNT in the adults. So, it should be differentiated clinically and radiographically from granulomatous or infectious conditions. Hence, a timely histologic diagnosis through a leptomeningeal biopsy of the brain and spinal cord in case of unusual leptomeningeal enhancement with uncertain laboratory findings is essential because cytological examination of the cerebrospinal fluid in DLGNT is known to be negative.

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