Effects of a Supervised Exercise Intervention on Recovery From Treatment Regimens in Breast Cancer Survivors

244 Background: Current literature suggests that weight gain during treatment for breast cancer is associated with a poorer prognosis and an increased risk of developing secondary health problems such as the metabolic syndrome (MetSyn). Physical activity (PA) can alter features of the MetSyn and improve body composition by reducing abdominal adiposity. We report metabolic results of a prospective randomized controlled trial (PEACH trial; Walsh JM, et al. [2010] BMC Cancer. 10[42]) which examines the effect of an exercise intervention on the metabolic risk profile of breast cancer survivors 2-6 months post chemotherapy. Methods: All subjects gave written informed consent and were randomized to an 8-week, twice weekly aerobic exercise intervention programme or a usual care control group consisting of routine medical advice about PA. The five clinical features of the MetSyn were measured: waist circumference (WC), resting blood pressure (BP), triglycerides, high-density lipoprotein cholesterol (HDL-C) and fasting glucose. Insulin resistance was estimated by the homeostatic model assessment (HOMA). Statistical analysis was carried out using independent sample t-tests with significance set at p < 0.05. Results: Twenty-six breast cancer survivors participated (mean (± SD) age 48.13 (8.75) years). At baseline, 50% (n = 13) of subjects were overweight and 23.1% (n = 6) were obese, with 73.1% (n = 19) centrally obese. 34.6% (n = 9) of subjects were classified with the MetSyn. There were no significant differences between groups at baseline. Intention-to-treat analysis showed no significant changes, however, analysis of those who adhered to > 70% of the supervised exercise intervention showed a significant improvement in WC when compared to the control group (p < 0.05). Conclusions: Results show that an 8-week aerobic exercise intervention significantly reduced WC but did not modify other features of the MetSyn. The decrease in WC demonstrated by this short intervention may have important implications in terms of improving survival and the metabolic risk profile of breast cancer survivors. Final follow-up assessments are ongoing and will enable change in WC over time to be evaluated further.

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Breast cancer survivors’ perceptions of participating in a supervised exercise intervention: An exploratory review of the literature

Women & Health ◽

10.1080/03630242.2017.1372844 ◽

2017 ◽

Vol 58 (9) ◽

pp. 1017-1036 ◽

Cited By ~ 4

Author(s):

Leanne Livsey ◽

Kiara Lewis

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Review Of The Literature ◽

Supervised Exercise

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Theory-based predictors of follow-up exercise behavior after a supervised exercise intervention in older breast cancer survivors

Supportive Care in Cancer ◽

10.1007/s00520-011-1360-0 ◽

2012 ◽

Vol 20 (10) ◽

pp. 2511-2521 ◽

Cited By ~ 34

Author(s):

Paul D. Loprinzi ◽

Bradley J. Cardinal ◽

Qi Si ◽

Jill A. Bennett ◽

Kerri M. Winters-Stone

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Exercise Behavior ◽

Supervised Exercise

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Recruitment of breast cancer survivors into a 12-month supervised exercise intervention is feasible

Contemporary Clinical Trials ◽

10.1016/j.cct.2009.04.007 ◽

2009 ◽

Vol 30 (5) ◽

pp. 457-463 ◽

Cited By ~ 16

Author(s):

Heidi Penttinen ◽

Riku Nikander ◽

Carl Blomqvist ◽

Riitta Luoto ◽

Tiina Saarto

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Supervised Exercise

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Effect of Group Dynamics–Based Exercise Versus Personal Training in Breast Cancer Survivors

10.1188/19.onf.185-197 ◽

2019 ◽

pp. 185-197

Keyword(s):

Breast Cancer ◽

Physical Fitness ◽

Cancer Survivors ◽

Group Dynamics ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Training Intervention ◽

Personal Training ◽

Supervised Exercise

Objectives: To determine the feasibility and preliminary effectiveness of a group dynamics–based exercise intervention versus a personal training intervention for increasing physical activity (PA), physical fitness, and quality of life (QOL) in post-treatment breast cancer survivors. Sample & Setting: 26 women with stage I or II breast cancer who attended intervention activities at a local academic institution. Methods & Vriables: Participants were randomly assigned to receive an eight-week intervention in either a group dynamics–based exercise or a personal training setting. Both intervention arms received supervised exercise twice per week, as well as PA education and discussion sessions. Results: Significant increases were noted in both intervention arms for vigorous PA, chest press, and leg press. Increases in overall QOL and total PA were significant only in the group dynamics–based exercise intervention arm. Implications for Nursing: The group dynamics–based exercise intervention produced similar improvements in PA and physical fitness compared to the personal training intervention, and it may have facilitated greater improvements in overall QOL.

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Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors

Scientific Reports ◽

10.1038/s41598-021-96419-z ◽

2021 ◽

Vol 11 (1) ◽

Cited By ~ 1

Author(s):

Christina M. Dieli-Conwright ◽

Nathalie Sami ◽

Mary K. Norris ◽

Junxiang Wan ◽

Hiroshi Kumagai ◽

...

Keyword(s):

Breast Cancer ◽

Resistance Exercise ◽

Cancer Survivors ◽

Repeated Measures ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Care Group ◽

Post Exercise ◽

Increased Risk ◽

Hispanic White

AbstractMOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I–III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson’s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282.

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Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

Breast Cancer Research and Treatment ◽

10.1007/s10549-021-06363-9 ◽

2021 ◽

Author(s):

Roxanne Gal ◽

Evelyn M. Monninkhof ◽

Carla H. van Gils ◽

Rolf H. H. Groenwold ◽

Sjoerd G. Elias ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Beneficial Effect ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Intervention Group ◽

Control Group ◽

Physical Fatigue ◽

Trials Within Cohorts

Abstract Purpose The Trials within Cohorts (TwiCs) design aims to overcome problems faced in conventional RCTs. We evaluated the TwiCs design when estimating the effect of exercise on quality of life (QoL) and fatigue in inactive breast cancer survivors. Methods UMBRELLA Fit was conducted within the prospective UMBRELLA breast cancer cohort. Patients provided consent for future randomization at cohort entry. We randomized inactive patients 12–18 months after cohort enrollment. The intervention group (n = 130) was offered a 12-week supervised exercise intervention. The control group (n = 130) was not informed and received usual care. Six-month exercise effects on QoL and fatigue as measured in the cohort were analyzed with intention-to-treat (ITT), instrumental variable (IV), and propensity scores (PS) analyses. Results Fifty-two percent (n = 68) of inactive patients accepted the intervention. Physical activity increased in patients in the intervention group, but not in the control group. We found no benefit of exercise for dimensions of QoL (ITT difference global QoL: 0.8, 95% CI = − 2.2; 3.8) and fatigue, except for a small beneficial effect on physical fatigue (ITT difference: − 1.1, 95% CI = − 1.8; − 0.3; IV: − 1.9, 95% CI = − 3.3; − 0.5, PS: − 1.2, 95% CI = − 2.3; − 0.2). Conclusion TwiCs gave insight into exercise intervention acceptance: about half of inactive breast cancer survivors accepted the offer and increased physical activity levels. The offer resulted in no improvement on QoL, and a small beneficial effect on physical fatigue. Trial registration Netherlands Trial Register (NTR5482/NL.52062.041.15), date of registration: December 07, 2015.

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Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment

Cancer ◽

10.1002/cncr.22862 ◽

2007 ◽

Vol 110 (4) ◽

pp. 918-925 ◽

Cited By ~ 66

Author(s):

Carole M. Schneider ◽

City C. Hsieh ◽

Lisa K. Sprod ◽

Susan D. Carter ◽

Reid Hayward

Keyword(s):

Breast Cancer ◽

Exercise Training ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Cardiopulmonary Function ◽

Supervised Exercise

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Can Counseling Add Value to an Exercise Intervention for Improving Quality of Life in Breast Cancer Survivors? A Feasibility Study

The Journal of Supportive Oncology ◽

10.1016/j.suponc.2011.09.004 ◽

2012 ◽

Vol 10 (5) ◽

pp. 188-194 ◽

Cited By ~ 12

Author(s):

Fiona Naumann ◽

Eric Martin ◽

Martin Philpott ◽

Cathie Smith ◽

Diane Groff ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Survivors ◽

Feasibility Study ◽

Breast Cancer Survivors ◽

Exercise Intervention

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A Group Dynamics-Based Exercise Intervention to Improve Physical Activity Maintenance in Breast Cancer Survivors

Journal of Physical Activity and Health ◽

10.1123/jpah.2018-0667 ◽

2019 ◽

Vol 16 (9) ◽

pp. 785-791

Author(s):

Heather J. Leach ◽

Katie B. Potter ◽

Mary C. Hidde

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Survivors ◽

Group Dynamics ◽

Breast Cancer Survivors ◽

Exercise Intervention ◽

Intervention Group ◽

Group Cohesion ◽

Self Report

Background: To maintain increases in physical activity (PA), interventions that implement group dynamics principles and strategies with the intent of enhancing group cohesion may be advantageous. This study examined group cohesion and PA following a group dynamics-based PA intervention among breast cancer survivors. Methods: The study was designed as a pilot randomized controlled trial comparing an 8-week group dynamics-based intervention with an individually supervised intervention. Group cohesion was measured by the Physical Activity Group Environment Questionnaire, and PA was measured at baseline, post-intervention, and 3-month follow-up using a self-report questionnaire and pedometer. Results: Group cohesion levels were high following the intervention and positively associated with PA at 3-month follow-up (ranger = .182–.555). At 3-month follow-up, 91.7% of participants in the group-dynamics-based intervention (n = 12) were classified as moderately active or greater, compared with 54.5% in the individually supervised intervention (n = 11). Conclusions: These results suggest that, for breast cancer survivors, peer support and fostering group cohesion as part of an exercise program may help to support PA following the completion of a structured intervention. A larger trial with longer follow-up is needed to establish comparative efficacy for a group-dynamics-based exercise intervention to enhance long-term PA adherence in breast cancer survivors.

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