scholarly journals Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christina M. Dieli-Conwright ◽  
Nathalie Sami ◽  
Mary K. Norris ◽  
Junxiang Wan ◽  
Hiroshi Kumagai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Repeated Measures ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Care Group ◽  
Post Exercise ◽  
Increased Risk ◽  
Hispanic White

AbstractMOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potentially via ethnic-specific mtDNA variations. Women treated for breast cancer are at an increased risk for cardiovascular disease, diabetes and obesity, due to side effects of cancer-treatments. We conducted a secondary analysis of the effects of a 16-week aerobic and resistance exercise intervention on MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors (BCS). BCS (Stage I–III) were randomized to exercise or standard care. The intervention promoted aerobic and resistance exercise for 16 weeks. MOTS-c was analyzed in fasting plasma using an in-house ELISA. Within and between group differences were assessed by paired t-test and repeated measures ANOVA. Pearson’s correlation was computed to assess the association between MOTS-c and metabolic biomarkers at baseline and post-exercise. Twenty-five Hispanic-BCS and 24 non-Hispanic White BCS were included. Hispanic BCS were younger, of greater adiposity, had higher stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic White BCS (p < 0.001). Post-exercise, MOTS-c levels significantly increased when compared to baseline and the usual care group among non-Hispanic White BCS (p < 0.01) but not among Hispanic breast cancer survivors (p > 0.01). Post-exercise levels of MOTS-c among non-Hispanic White BCS were significantly associated with reductions in fat mass, body weight, HOMA-IR, CRP, and an increase in lean mass (p < 0.01). A 16-week aerobic and resistance intervention increased MOTS-c levels among non-Hispanic White BCS. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010. https://clinicaltrials.gov/ct2/show/NCT01140282.

scholarly journals Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

2020 ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

Aerobic and Resistance Exercise Improve Patient-reported Sleep Quality and is Associated with Cardiometabolic Biomarkers in Hispanic and Non-Hispanic Breast Cancer Survivors who are Overweight or Obese: Results from a Secondary Analysis

SLEEP ◽  
2021 ◽  
Author(s):  
Christina M Dieli-Conwright ◽  
Kerry S Courneya ◽  
Wendy Demark-Wahnefried ◽  
Nathalie Sami ◽  
Mary K Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Secondary Analysis ◽  
Exercise Group ◽  
Hispanic Ethnicity ◽  
Patient Reported

Abstract Study Objectives Poor sleep quality affects nearly one third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality. Methods Breast cancer survivors who were overweight or obese were randomized to exercise (n=50) or usual care (n=50). The 16-week intervention included aerobic and resistance exercise. Patient-reported sleep quality [Pittsburgh Sleep Quality Index (PSQI)] and biomarkers of cardiometabolic health were assessed at baseline and post-intervention. Within- and between-group differences were assessed using general linear models repeated-measures ANOVAs and mixed-model repeated measure analysis, respectively. Associations between changes in PSQI and cardiometabolic biomarkers were computed using Pearson correlations. Linear mixed-models were used to evaluate effect modification by ethnicity. Results Participants were 52±10.4 years old, and over half were of Hispanic ethnicity. As compared to usual care, PSQI global scores improved significantly in the exercise group (mean between group difference -2.2; 95% CI -3.2 to -0.6). Change in PSQI was inversely associated with changes in all cardiometabolic biomarkers (p&lt;0.01) among the exercise group. Ethnicity was found to moderate the effects of exercise training on global sleep quality (p&lt;0.001). Conclusions An aerobic and resistance exercise intervention effectively improved patient-reported sleep quality in breast cancer survivors. Hispanic ethnicity as a moderator showed greater improvement in patient-reported sleep indicating Hispanic versus non-Hispanic breast cancer survivors may derive larger sleep benefits.

Metabolic syndrome and breast cancer: Effects of a 16-week combined exercise intervention.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. TPS9648-TPS9648
Author(s):  
Christina Marie Dieli-Conwright ◽  
Debu Tripathy ◽  
E. Todd Schroeder ◽  
Joanne E. Mortimer ◽  
Leslie Bernstein
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Current Evidence ◽  
Comprehensive Cancer Center ◽  
Increased Risk ◽  
Risk Of Cancer

TPS9648 Background: Current evidence suggests that breast cancer treatments such as chemotherapy lead to excessive weight gain, fatigue, physical inactivity, and negative alterations in components of metabolic syndrome (MetS). MetS is associated with increased risk of cancer recurrence, cardiovascular diseases and type 2 diabetes, and is defined by visceral adiposity, insulin resistance, hyperglycemia, hyperinsulinemia, low serum high-density lipoprotein cholesterol, and hypertension. MetS is highly prevalent and present in 25% of American and European adults and higher in minorities. Given that chemotherapy for breast cancer induces many of the components of MetS, an effort to offset these consequences of cancer therapy using exercise/lifestyle intervention could improve breast cancer, cardiovascular and endocrine outcomes. Methods: Our study seeks to determine whether a 16-week exercise intervention induces changes in prognostic components of MetS (waist circumference, blood pressure, serum levels of glucose, insulin, lipids, C-reactive protein and HbA1c) among breast cancer survivors if initiated within 3 months of completion of chemotherapy or radiation therapy. We are currently recruiting women diagnosed with Stage I-III breast cancer from the USC Norris Comprehensive Cancer Center and Los Angeles County Hospital, which cares for a high proportion of minority/underserved patients. Participants are randomized to either the Control (usual care) or the Exercise group. The Exercise group participates in aerobic and resistance exercise sessions 3 times a week for 16 weeks supervised by an exercise specialist at the USC Clinical Exercise Research Center. At baseline and following the study period, all participants are tested for MetS components, muscle strength, body composition, bone density, cardiorespiratory fitness, quality of life, fatigue and shoulder function. We will recruit an additional 85 patients (at present time n=15) over the next 3 years. It is expected that this intervention will improve components of MetS and physical fitness in breast cancer survivors when compared to the Control group, thus defining intervention and biomarker variables for more definitive trials. Clinical trial information: NCT01140282.

scholarly journals Aerobic and resistance exercise improves Reynolds risk score in overweight or obese breast cancer survivors

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
Mary K. Norris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and results One hundred overweight or obese (BMI > 25 kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9 ± 0.9% to 1.0 ± 0.5%; p < 0.001) in the exercise group compared to a significant increase (9.0 ± 0.8% to 11.6 ± 1.2%; p = 0.002%) in the usual care group (p < 0.01). RRS was significantly reduced in exercise vs usual care (between group difference, − 10.6; 95% CI, − 16.3 to − 7.4; p < 0.001). Conclusion A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors. Trial registration ClinicalTrials.gov: NCT01140282. Registered 9 June 2010

scholarly journals Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Gwendolyn A. Thomas ◽  
Marty Alvarez-Reeves ◽  
Lingeng Lu ◽  
Herbert Yu ◽  
Melinda L. Irwin
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Exercise Adherence ◽  
Postmenopausal Breast Cancer ◽  
Increased Risk

Objective. Breast cancer survivors are highly sedentary, overweight, or obese, which puts them at increased risk for comorbid chronic disease. We examined the prevalence of, and changes in, metabolic syndrome following 6 months of an aerobic exercise versus usual care intervention in a sample of sedentary postmenopausal breast cancer survivors.Design and Methods. 65 participants were randomized to an aerobic exercise intervention (EX) (n=35) mean BMI 30.8 (±5.9) kg/m2or usual care (UC) (n=30) mean BMI 29.4 (±7.4) kg/m2. Metabolic syndrome prevalence was determined, as well as change in criteria and overall metabolic syndrome.Results. At baseline, 55.4% of total women met the criteria for metabolic syndrome. There was no statistically significant change in metabolic syndrome when comparing EX and UC. However, adhering to the exercise intervention (at least 120 mins/week of exercise) resulted in a significant (P=.009) decrease in metabolic syndromez-score from baseline to 6 months (-0.76±0.36) when compared to those who did not adhere (0.80±0.42).Conclusions. Due to a higher prevalence of metabolic syndrome in breast cancer survivors, lifestyle interventions are needed to prevent chronic diseases associated with obesity. Increasing exercise adherence is a necessary target for further research in obese breast cancer survivors.

scholarly journals Aerobic and Resistance Exercise Improves Reynolds Risk Score in Overweight or Obese Breast Cancer Survivors

2020 ◽  
Author(s):  
Christina Dieli-Conwright ◽  
Kyuwan Lee ◽  
Nathalie Sami ◽  
Debu Tripathy ◽  
Wendy Demark-Wahnefried ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiovascular Disease ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Usual Care ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Exercise Group

Abstract Background: Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors. Methods and Results: One hundred overweight or obese (BMI>25kg/m2) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9±0.9% to 1.0±0.5%, p<0.001) in the exercise group compared to a significant increase (9.0±0.8% to 11.6±1.2%; p=0.002%) in the usual care group (P<0.01). RRS was significantly reduced in exercise vs usual care (between group difference, -10.6; 95% CI, -16.3 to -7.4; p<0.001). Conclusion: A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in breast cancer survivors.Trial registration: ClinicalTrials.gov: NCT01140282. Registered 9 June 2010, https://clinicaltrials.gov/ct2/show/NCT01140282?term=NCT01140282&draw=2&rank=1

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