scholarly journals High-dose olanzapine in treatment resistant schizophrenia. A case report and literature review

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S115-S115
Author(s):  
Ciara Clarke ◽  
Clodagh Rushe ◽  
Fintan Byrne
Keyword(s):  
Case Report ◽  
Literature Review ◽  
The Body ◽  
Psychotic Symptoms ◽  
High Dose ◽  
Extensive Literature ◽  
Treatment Resistant ◽  
Persecutory Delusions ◽  
Full Resolution ◽  
One Year

ObjectiveWe report a case of a 58-year-old gentleman who was hospitalised intermittently for one year due to treatment resistant schizophrenia. Prior to hospitalisation he had been prescribed standard antipsychotics for decades without full resolution of positive psychotic symptoms. During his final admission lasting six months he was guarded, suspicious, irritable, constantly paced the corridor and displayed thought block and paranoid persecutory delusions. He would not enter the assessment room or allow any blood or ECG monitoring, however, he was compliant with oral medication. He was successfully treated with high dose olanzapine (40mg/day) and was discharged to the community. The aim of this study is to bring awareness and add to the body of evidence for the use of high-dose olanzapine in patients with treatment resistant schizophrenia in whom a trial of clozapine is not possible.Case reportThe patient gave written consent for this case report to be written and presented. An extensive literature review was performed and key papers were identified. Discussion focuses on the key areas in the literature.DiscussionThis case demonstrates that high-dose olanzapine can be used effectively as an alternative to clozapine in treatment resistant schizophrenia.ConclusionThis case highlights the need for further evaluation of high-dose olanzapine as an alternative to clozapine in patients with treatment-resistant schizophrenia.

scholarly journals ORAL SECONDARY INFECTION IN STEVENS-JOHNSON SYNDROME PATIENT WITH ORAL INVOLVEMENT: A CASE REPORT

2021 ◽  
Vol 6 (1) ◽  
pp. 79
Author(s):  
Etis Duhita Rahayuningtyas ◽  
Indah Suasani Wahyuni ◽  
Irna Sufiawati
Keyword(s):  
Case Report ◽  
Secondary Infection ◽  
Severity Of Illness ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
Oral Manifestation ◽  
Secondary Infections ◽  
Johnson Syndrome ◽  
Oral Involvement

ABSTRACTBackground: Stevens-Johnson syndrome (SSJ) is a hypersensitivity reaction that is often triggered by drugs but this case is rare. These reactions result in uncontrolled keratinocyte damage to the skin and mucosa throughout the body, including the oral mucosa, and are often life-threatening. The use of high doses of corticosteroids is a treatment that is often given but it can trigger secondary infections of fungal and viral in the oral cavity. Purpose: This case report discusses the management of oral manifestations and secondary infections in SSJ patients, and becomes guidance for health professionals. Case: A-42-years-old male patient was consulted from the Department of Dermatology and Venereology (DV) due to oral pain and eating difficulties. The severity-of-illness-score for toxic-epidermal-necrolysis (SCORTEN) was 1. Erosive serosanguinous crusts, tend to bleed were found on the lips. Intraoral clinically presented wide erosive lesions and multiple ulcers, accompanied by a pseudomembranous plaque, and teeth decay. Hematologic examination showed an increase in leukocytes, neutrophil segments, monocytes, SGOT, urea, and creatinine as well as decreased hemoglobin, hematocrit, erythrocytes, MCHC, protein, and albumin. Anti-HSV1 IgG increased almost 6 times than normal values. The patient was diagnosed with SJS with oral involvement, secondary infections of pseudomembranous candidiasis, and herpetic stomatitis. Case Management: Systemic therapy given were intravenous dexamethasone, ranitidine, calcium, and cetirizine, from the DV Department, while hydrocortisone lip ointment, Chlorhexidine digluconate 0.12%, and Nystatin oral suspension for oral problems. The lesions progressed in 24 days. Conclusion: Oral secondary infections may occur in SJS patients due to high-dose corticosteroid therapy.Keywords: Herpetic Stomatitis, Oral Manifestation, Oral Secondary Infection, Pseudomembranous Candidiasis, Stevens-Johnson Syndrome.

High-dose adenosine for refractory supraventricular tachycardia: a case report and literature review

2016 ◽  
Vol 27 (5) ◽  
pp. 981-984 ◽  
Author(s):  
Gal Dadi ◽  
Daniel Fink ◽  
Giora Weiser
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
Literature Review ◽  
Cardiogenic Shock ◽  
Sinus Rhythm ◽  
Supraventricular Tachycardia ◽  
Electrical Cardioversion ◽  
High Dose ◽  
Prompt Treatment ◽  
Unstable Patient

AbstractSupraventricular tachycardia is the most common significant arrhythmia in children. If prolonged, it may cause heart failure and progress to cardiogenic shock warranting prompt treatment. The recommended interventions following vagal manoeuvres are intravenous adenosine and in the unstable patient electrical cardioversion. We present an infant with an unstable supraventricular tachycardia that was resistant to electrical cardioversion and recommended doses of adenosine. He reverted to sinus rhythm with a higher dose of adenosine, suggesting that such doses may be required in refractory supraventricular tachycardia.

Accidental shortening time of high dose methotrexate infusion: case report and literature review

2013 ◽  
Vol 71 (2) ◽  
pp. 219-222 ◽  
Author(s):  
Rim Charfi ◽  
Issam Salouage ◽  
Sameh Trabelsi ◽  
Mohamed Zarrouk ◽  
Emna Gaïes ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

scholarly journals Interstitial high-dose-rate brachytherapy as a boost in synchronous prostate and rectal cancer treatment: case report and literature review

2020 ◽  
Vol 12 (2) ◽  
pp. 181-187
Author(s):  
Katarzyna Konat-Bąska ◽  
Adam Chicheł ◽  
Urszula Staszek-Szewczyk ◽  
Adam Maciejczyk ◽  
Rafał Matkowski
Keyword(s):  
Rectal Cancer ◽  
Case Report ◽  
Literature Review ◽  
Cancer Treatment ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
High Dose Rate Brachytherapy ◽  
Rectal Cancer Treatment

scholarly journals Treatment-resistant psychotic symptoms and the 15q11.2 BP1–BP2 (Burnside-Butler) deletion syndrome: case report and review of the literature

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Martilias Farrell ◽  
Maya Lichtenstein ◽  
Matthew K. Harner ◽  
James J. Crowley ◽  
Dawn M. Filmyer ◽  
...  
Keyword(s):  
Case Report ◽  
Deletion Syndrome ◽  
Psychotic Symptoms ◽  
Review Of The Literature ◽  
Treatment Resistant

scholarly journals Epidermoid Cyst Arising on the Body of the Tongue: Case Report and Literature Review

2018 ◽  
Vol 85 (6) ◽  
pp. 343-346 ◽  
Author(s):  
Takashi Ueno ◽  
Ryoko Takayama ◽  
Shin-Ichi Osada ◽  
Hidehisa Saeki
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Epidermoid Cyst ◽  
The Body

High-dose Supplementation With Vitamin C–induced Pediatric Urolithiasis: The First Case Report in a Child and Literature Review

Urology ◽  
2014 ◽  
Vol 84 (4) ◽  
pp. 922-924 ◽  
Author(s):  
Xuehua Chen ◽  
Luming Shen ◽  
Xiaojian Gu ◽  
Xinjuan Dai ◽  
Li Zhang ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Vitamin C ◽  
High Dose ◽  
Pediatric Urolithiasis ◽  
First Case
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