scholarly journals A study examining whether social cognitive abilities impact on recovery from PTSD

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S302-S302
Author(s):  
Chantelle Wiseman ◽  
Jonathan Bisson ◽  
Anke Karl ◽  
Andrew Lawrence ◽  
James Hotham ◽  
...  

AimsDeficits in social cognition (the ability to recognise and understand emotions, intentions and actions in oneself and in others) have been found in people with post-traumatic stress disorder (PTSD). Few studies so far have examined whether social cognitive ability impacts on PTSD recovery. Here we present a protocol and preliminary data for a study that aims to evaluate whether pre-treatment social cognitive deficits are associated with treatment outcomes following trauma-focused therapy for PTSD.MethodThe protocol was developed after discussion with Patient and Public Involvement (PPI) groups, and a battery of social cognitive tasks was trialled on 20 participants without PTSD. The final protocol was then developed using information and feedback from these preliminary studies. We aim to recruit 60 individuals who are about to start a trauma-focused therapy for PTSD within the two tertiary PTSD services. Social cognition (measured using a variety of tasks including Reading the Mind in the Eyes Task and the Reflective Functioning Questionnaire) and potential confounders (including severity of trauma history, attachment and verbal IQ) are assessed at baseline, prior to the start of therapy. PTSD symptom severity (measured using the PCL-5) and daily functioning (measured using the WSAS) are assessed pre and post-treatment. The primary aim of the study is to examine whether baseline social cognition is associated with the degree of improvement in the PCL-5.ResultSo far 29 participants have been recruited and consented. 6 participants have completed follow-up assessments. The study has been adapted for the COVID-19 pandemic so participants can complete the tasks remotely. Preliminary results show a moderate negative correlation between baseline social cognitive abilities and baseline PTSD symptom severity (Spearman's correlation -0.30) and functional abilities (Spearman's correlation -0.42).ConclusionDevelopment of our study in collaboration with PPI and preliminary testing of measures suggests it is likely that it will be feasible for us to conduct this study in this patient group. Baseline preliminary results show/suggest a moderate correlation between PTSD symptom severity and social cognitive impairment. Our main analyses, when completed, will help to determine whether social cognitive ability is associated with recovery from PTSD.

2017 ◽  
Vol 31 (3) ◽  
pp. 326-335 ◽  
Author(s):  
Bryce Hruska ◽  
Maria L. Pacella ◽  
Richard L. George ◽  
Douglas L. Delahanty

2008 ◽  
Author(s):  
Katherine Stephenson ◽  
David Valentiner ◽  
Holly Orcutt ◽  
Mandy Rabenhorst ◽  
Leslie Matuszewich

2013 ◽  
Author(s):  
Ryan N. Reed ◽  
Jeffrey S. Simons ◽  
Raluca M. Gaher

2013 ◽  
Author(s):  
Meghan M. McGinn ◽  
Katherine D. Hoerster ◽  
Carol Malte ◽  
Stephen Hunt ◽  
Matthew Jakupcak

2010 ◽  
Author(s):  
J. J. Vasterling ◽  
S. P. Proctor ◽  
M. J. Friedman ◽  
C. W. Hoge ◽  
T. Heeren ◽  
...  

Author(s):  
Consuelo Arbona ◽  
L. Rodriguez ◽  
M. Dragomir-Davis ◽  
N. Olvera ◽  
M. A. de Dios ◽  
...  

Author(s):  
Minlan Yuan ◽  
Hongru Zhu ◽  
Yuchen Li ◽  
Fenfen Ge ◽  
Su Lui ◽  
...  

Abstract Rationale and objectives The hippocampus, especially the CA1, CA3, and dentate gyrus (DG) subfields, is reported to be associated with post-traumatic stress disorder (PTSD) after trauma. However, neuroimaging studies of the associations between PTSD and hippocampal subfield volumes have failed to yield consistent findings. The aim of this study is to examine whether the dopamine D2 receptor (DRD2) Taq1A polymorphism, which is associated with both hippocampal function and PTSD, moderated the association between PTSD severity and hippocampal CA1, CA3 and DG volumes. Methods T1-weighted images were acquired from 142 trauma survivors from the 2008 Wenchuan earthquake using a 3.0-T magnetic resonance imaging system. Hippocampal subfield segmentations were performed with FreeSurfer v6.0. We used the simple moderation model from the PROCESS v3.4 tool for SPSS 23.0 to examine the association between the rs1800497 polymorphism, PTSD severity, and hippocampal CA3 and DG volumes. Results A significant genotype × PTSD symptom severity interaction was found for the left CA3 volume (ΔF = 5.01, p = 0.008, ΔR2 = 0.05). Post hoc, exploratory analyses deconstructing the interaction revealed that severe PTSD symptomatology were associated with reduced left CA3 volume among TC heterozygotes (t =  − 2.86, p = 0.005). Conclusions This study suggests that DRD2 Taq1A polymorphism moderates the association between PTSD symptomatology and left CA3 volume, which promotes an etiological understanding of the hippocampal atrophy at the subfield level. This highlights the complex effect of environmental stress, and provides possible mechanism for the relationship between the dopaminergic system and hippocampal function in PTSD.


2021 ◽  
Vol 115 ◽  
pp. 105023
Author(s):  
Jenny Chen ◽  
Nicole M. Christ ◽  
Chia-Hao Shih ◽  
Hong Xie ◽  
Stephen R. Grider ◽  
...  

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