Hamilton Rating Scale for Depression with Medical In-Patients

1967 ◽  
Vol 113 (494) ◽  
pp. 83-88 ◽  
Author(s):  
John J. Schwab ◽  
Martin R. Bialow ◽  
Roy S. Clemmons ◽  
Charles E. Holzer
Keyword(s):  
Patient Population ◽  
Rating Scale ◽  
Psychiatric Patients ◽  
Depressive Illness ◽  
Medical Patients ◽  
Antidepressant Medications ◽  
Results Of Treatment ◽  
Severity Of Depression ◽  
Hamilton Rating Scale ◽  
Comprehensive Study

This report evaluates the use of the Hamilton Rating Scale for Depression (HRS) (5) in a general medical in-patient population; it is one part of a comprehensive study of depression in these patients (10, 11). The Hamilton Rating Scale was designed to measure the severity of depression in patients already diagnosed as having depressive illness. Hamilton (5) states, “the scale quantifies the results of an interview and is of practical value in assessing the results of treatment.” Recently, the HRS has been used for measuring psychiatric patients' responses to antidepressant medications (7, 9, 12), but there are no reports of its use with medical patients.

Effects of ECT on Prolactin, LH, FSH and Testosterone in Males with Major Depressive Illness*

1989 ◽  
Vol 34 (8) ◽  
pp. 814-817 ◽  
Author(s):  
A.J. Cooper ◽  
R. Finlayson ◽  
V.R. Velamoor ◽  
R.V. Magnus ◽  
Z. Cernovsky
Keyword(s):  
Luteinizing Hormone ◽  
Sexual Functioning ◽  
Rating Scale ◽  
Follicle Stimulating Hormone ◽  
Depressive Illness ◽  
Serum Prolactin ◽  
Major Depressive ◽  
Treatment Changes ◽  
Severity Of Depression ◽  
Hamilton Rating Scale

Fourteen males with major depressive illness (DSM-III) received a course of electroconvulsive therapy (ECT). Serum prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T), were measured 15 minutes before and 15 minutes after each treatment. The severity of depression was assessed with the Hamilton Rating Scale for Depression (HRSD) two to three days before the first and two to three days following the last treatment. Post-ECT levels of PRL and LH were significantly higher than pre-ECT levels across every treatment. Changes in FSH and testosterone were not significant. There were no relationships between hormone levels (first versus last ECT) and severity of depression, including sexual functioning. It is argued that the relatively greater increases of LH than FSH is due to an acute antidopaminergic action of ECT which acts selectively on the secretion of the former. The blunted testosterone response to the increase of gonadotropins may be due to ECT-induced hyperprolactinemia.

A Controlled Comparative Trial of a New Antidepressant, Ciclazindol

1979 ◽  
Vol 7 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sidney Levine
Keyword(s):  
Rating Scale ◽  
Comparative Trial ◽  
Poor Response ◽  
Endogenous Depression ◽  
Depressive Illness ◽  
Double Blind ◽  
Significant Difference ◽  
Severity Of Depression ◽  
The Mean ◽  
Rate Of Response

The author describes a controlled, double-blind, comparative trial of a new tetracyclic compound, ciclazindol (WY 23409), against amitriptyline in the treatment of thirty-five patients admitted to hospital with depressive illness. Each patient was randomly allocated to three weeks treatment with either 50 mg b.d. ciclazindol or 50 mg b.d. amitriptyline. In the event of a poor response the dose level was raised to 75 mg b.d. Separation of cases of endogenous depression and severity of depression were assessed by the Levine-Pilowsky Depression Questionnaire, a self-rating technique. Severity of depression was also assessed using the Hamilton Rating Scale. No significant difference was noted between the drugs in either the degree or the rate of response nor when the endogenous cases alone were studied. The interesting observation was made that only one-third of ciclazindol patients gained weight compared to almost three-quarters of the amitriptyline group and the mean weight gain of the latter was over double that of the ciclazindol group. The author concludes that ciclazindol offers promise and merits further study using higher dosage levels once its full safety trials have been completed.

Brief Communication The movement of hostility during recovery from depression

1978 ◽  
Vol 8 (1) ◽  
pp. 145-149 ◽  
Author(s):  
G. C. Lyketsos ◽  
Ivy M. Blackburn ◽  
J. Tsiantis
Keyword(s):  
Rating Scale ◽  
Depressive Illness ◽  
Depression Score ◽  
National Norms ◽  
Hamilton Rating Scale ◽  
Over Time

SynopsisSixteen depressed in-patients from a hospital in Athens were assessed using the Hamilton Rating Scale and the Hostility and Direction of Hostility Questionnaire. Comparison of admission, discharge and mid-treatment scores showed that:(1) There was a larger drop in depression score in the first half of treatment.(2) Hostility scores, except for extrapunitiveness, decreased significantly over time, larger changes occurring in the first half of treatment.(3) Comparisons with British scores showed that during illness there were no significant differences between British and Greeks, though the latter tended to be more extrapunitive. At recovery, the Greeks were significantly more extrapunitive.The movement of hostility in depressive illness, the validity of the HDHQ and need for national norms are discussed.

Studies of Depressive Symptoms in Schizophrenia

1981 ◽  
Vol 139 (2) ◽  
pp. 89-101 ◽  
Author(s):  
D. A. W. Johnson
Keyword(s):  
Depressive Symptoms ◽  
Rating Scale ◽  
Depressive Illness ◽  
Extrapyramidal Side Effects ◽  
Chronic Schizophrenics ◽  
Prevalence Of Depression ◽  
Depot Neuroleptic ◽  
Depot Injections ◽  
Higher Doses ◽  
Hamilton Rating Scale

SummaryDepression assessed by clinical examination and Hamilton rating scale was found in half of 37 untreated new acute schizophrenics, and in about a third of chronic schizophrenics who relapsed whether treated with depot injections (89) or not (79). A significant part of depressive illness in schizophrenics is thus not drug-related. However, depression was commoner in those on higher doses of depot neuroleptic (P <.05) or who showed extrapyramidal side effects (P <.001), suggesting that drugs can play a part. Patients maintained in remission on moderate doses of depot drug had the lowest prevalence of depression.

Is There a Delay in the Onset of the Antidepressant Effect of Electroconvulsive Therapy?

1994 ◽  
Vol 164 (1) ◽  
pp. 106-109 ◽  
Author(s):  
Colin R. Rodger ◽  
Allan I. F. Scott ◽  
Lawrence J. Whalley
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Antidepressant Effect ◽  
Major Depressive ◽  
Depressed Patients ◽  
Severity Of Depression ◽  
Drug Free ◽  
Hamilton Rating Scale

The severity of depression in 11 drug-free unipolar patients diagnosed with definite major depressive disorder was assessed using the Hamilton Rating Scale for Depression during a course (5–10 treatments) of bilateral electroconvulsive therapy (ECT). The degree of improvement after three treatments of ECT was six times greater than the improvement that occurred over the remainder of the course. Although depressed patients who recover with ECT require repeated treatments, the treatments early in a course of ECT can have marked antidepressant effect.

A Clinical Trial of ICI 58,834 – A Potential Anti-Depressant

1973 ◽  
Vol 1 (7) ◽  
pp. 624-626 ◽  
Author(s):  
Malcolm Peet
Keyword(s):  
Clinical Trial ◽  
Clinical Response ◽  
Rating Scale ◽  
Controlled Trial ◽  
Antidepressant Activity ◽  
Depressive Illness ◽  
Blood Levels ◽  
Significant Difference ◽  
Single Blind ◽  
Hamilton Rating Scale

Twenty-four in-patients with depressive illness were treated with either ICI 58,834 or imipramine for twenty-one days in a single-blind controlled trial. No statistically significant difference in response was found between the two groups, as assessed by the Hamilton Rating Scale and the Beck Depression Inventory. Blood levels of ICI 58,834 at one hour were not correlated with clinical response. Nausea and vomiting occurred in three patients taking ICI 58,834. It is concluded that further investigation of the apparent antidepressant activity of this new drug is indicated.

Rating Scales as Predictors of Response to Tricyclic Antidepressants

1976 ◽  
Vol 10 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Graham D. Burrows ◽  
George Foenander ◽  
Brian Davies ◽  
Bruce A. Scoggins
Keyword(s):  
Tricyclic Antidepressants ◽  
Rating Scales ◽  
Rating Scale ◽  
Depressive Illness ◽  
Predictors Of Response ◽  
Significant Difference ◽  
Scale Scores ◽  
Nortriptyline Hydrochloride ◽  
Hamilton Rating Scale ◽  
Predict Treatment Response

Fifty-three patients suffering from depressive illness were classified as ‘responders’ or ‘non-responders’ on the basis of an “amelioration score” of the Hamilton Rating Scale for depression after six weeks treatment with nortriptyline hydrochloride at 150 mgs. daily. A multivariate analysis of variance was performed on the four psychological rating scale scores used, to determine whether rating scales could predict treatment response to tricyclic antidepressants. There was a significant difference between the two groups after adjustment for age. Subjects were then classified as ‘non-responders’ and ‘responders’ on the basis of their discriminant scores. The prediction of response to tricyclic antidepressants was found to be at 75% probability.

Dynamical Patterns in Bipolar Depression

2002 ◽  
Vol 6 (4) ◽  
pp. 380-387 ◽  
Author(s):  
Sheri L. Johnson ◽  
Andrzej Nowak
Keyword(s):  
Rating Scale ◽  
Bipolar Depression ◽  
Bipolar I Disorder ◽  
Severity Of Depression ◽  
Hamilton Rating Scale ◽  
Dynamical Patterns

We examined dynamical patterns in the course of bipolar depression. We interviewed 55 individuals with bipolar I disorder using Modified Hamilton Rating Scale for Depression (MHRSD) for at least 20 months. Using a recently developed methodology, we categorized the level of instability and the nature of attractor patterns for each individual. Instability was related to the lifetime severity of depression as well as suicidality during the follow-up period. Individuals varied from 0 to 2 in the number of attractors. Relatively few individuals displayed only one attractor that fell within a depressive range; the most common patterns were instability and two attractors. Limitations and implications of these results are discussed.

A Japanese Scale to Assess Anxiety Severity: Development and Psychometric Evaluation

2011 ◽  
Vol 41 (1) ◽  
pp. 29-45 ◽  
Author(s):  
Chizu Mimura ◽  
Miho Nishioka ◽  
Noriyuki Sato ◽  
Ryoko Hasegawa ◽  
Ryu Horikoshi ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Rating Scale ◽  
Dynamic Range ◽  
Psychiatric Patients ◽  
Psychometric Evaluation ◽  
Anxiety Scale ◽  
Self Rating ◽  
Confirmatory Factor ◽  
Interview Guide ◽  
Hamilton Rating Scale

Objective: This study developed a Japanese self-rating anxiety scale, the Himorogi Self-rating Anxiety Scale (HSAS), and tested psychometric properties of its use in Japanese psychiatric patients. Methods: The process of developing the scale consisted of an intensive literature review, assessment of existing instruments, and detailed discussion on the content of the newly developed scale. Data for psychometric evaluation were collected from 419 outpatients of psychiatric clinics. The Hamilton Rating Scale for Anxiety Interview Guide (HAMA-IG) and the Sheehan Patient Rated Anxiety Scale (SPRAS) were used as standards against which the HSAS was compared. Results: Confirmatory factor analysis revealed a unifactorial nature for the HSAS and fewer insignificant items in the HSAS than the HAMA-IG and the SPRAS. Cronbach's alpha and test-retest coefficients indicated sufficient reliability. High correlation with the HAMA-IG and the SPRAS indicated evidence of convergence for the HSAS. ROC analysis showed high ability to distinguish between the presence and absence or remission of anxiety. Analysis of descriptive data suggested a larger dynamic range for the HSAS than the HAMA-IG and the SPRAS. Conclusions: The HSAS is a brief scale to assess anxiety severity, demonstrating evidence of good psychometric properties. It is recommended for use in research and clinical practice.

Screening for depression in hospitalised elderly medical patients

1996 ◽  
Vol 13 (4) ◽  
pp. 144-147
Author(s):  
Barbara Farragher ◽  
Margo Wrigley ◽  
Orla Donohoe ◽  
Joseph Duggan
Keyword(s):  
Old Age ◽  
Rating Scale ◽  
Antidepressant Medication ◽  
Depressive Illness ◽  
Consecutive Series ◽  
Medical Patients ◽  
Screening Questionnaire ◽  
Medically Ill ◽  
Hospitalised Patients ◽  
Depressed Group

AbstractObjective: The aim of this study was to screen a group of medically ill elderly hospitalised patients for depression and to facilitate this using a new screening questionnaire called the Evans Liverpool Depression Rating Scale (ELDRS).Method: The questionnaire was administered by a geriatric registrar to a consecutive series of 37 acutely ill elderly medical inpatients admitted to an acute hospital ward. They were subsequently interviewed by a member of the psychiatry of old age team.Results: Seven of the 37 acutely ill elderly patients admitted to hospital were found to be suffering from a major depressive illness according to DSMIIIR criteria. Of the patients screened, two were already on antidepressant medication. Five of the depressed patients were identified by using the ELDRS. All of the depressed group were judged to require antidepressant medication and two were referred to a psychiatry of old age day hospital.Conclusions: Our results suggest that there is a raised prevalence of depressive illness in elderly acutely ill medical patients which remains undetected. Use of a screening questionnaire such as the ELDRS would increase the likelihood of its identification in this group.

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