Rating Scales as Predictors of Response to Tricyclic Antidepressants

1976 ◽  
Vol 10 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Graham D. Burrows ◽  
George Foenander ◽  
Brian Davies ◽  
Bruce A. Scoggins
Keyword(s):  
Tricyclic Antidepressants ◽  
Rating Scales ◽  
Rating Scale ◽  
Depressive Illness ◽  
Predictors Of Response ◽  
Significant Difference ◽  
Scale Scores ◽  
Nortriptyline Hydrochloride ◽  
Hamilton Rating Scale ◽  
Predict Treatment Response

Fifty-three patients suffering from depressive illness were classified as ‘responders’ or ‘non-responders’ on the basis of an “amelioration score” of the Hamilton Rating Scale for depression after six weeks treatment with nortriptyline hydrochloride at 150 mgs. daily. A multivariate analysis of variance was performed on the four psychological rating scale scores used, to determine whether rating scales could predict treatment response to tricyclic antidepressants. There was a significant difference between the two groups after adjustment for age. Subjects were then classified as ‘non-responders’ and ‘responders’ on the basis of their discriminant scores. The prediction of response to tricyclic antidepressants was found to be at 75% probability.

A Clinical Trial of ICI 58,834 – A Potential Anti-Depressant

1973 ◽  
Vol 1 (7) ◽  
pp. 624-626 ◽  
Author(s):  
Malcolm Peet
Keyword(s):  
Clinical Trial ◽  
Clinical Response ◽  
Rating Scale ◽  
Controlled Trial ◽  
Antidepressant Activity ◽  
Depressive Illness ◽  
Blood Levels ◽  
Significant Difference ◽  
Single Blind ◽  
Hamilton Rating Scale

Twenty-four in-patients with depressive illness were treated with either ICI 58,834 or imipramine for twenty-one days in a single-blind controlled trial. No statistically significant difference in response was found between the two groups, as assessed by the Hamilton Rating Scale and the Beck Depression Inventory. Blood levels of ICI 58,834 at one hour were not correlated with clinical response. Nausea and vomiting occurred in three patients taking ICI 58,834. It is concluded that further investigation of the apparent antidepressant activity of this new drug is indicated.

scholarly journals Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259861
Author(s):  
Caoimhe Fenton ◽  
Declan M. McLoughlin
Keyword(s):  
Predictive Value ◽  
Rating Scales ◽  
Rating Scale ◽  
Secondary Analysis ◽  
Predictive Ability ◽  
Early Improvement ◽  
Receiver Operating Characteristic Curves ◽  
Predictors Of Response ◽  
Therapeutic Outcomes ◽  
Hamilton Rating Scale

Objectives We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. Methods This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three ‘full’ versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items. Results The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission. Conclusions Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.

Comparison of Propofol and Methohexitone in Anaesthesia for ECT: Effect on Seizure Duration and Outcome

1995 ◽  
Vol 29 (2) ◽  
pp. 299-303 ◽  
Author(s):  
Kenneth Clifford Kirkby ◽  
Warren Grant Beckett ◽  
Ruth Mima Matters ◽  
T. E. King
Keyword(s):  
Tricyclic Antidepressants ◽  
Rating Scales ◽  
Rating Scale ◽  
Total Duration ◽  
Double Blind Study ◽  
Seizure Duration ◽  
Double Blind ◽  
Hamilton Rating Scale ◽  
Induction Agents

The effect of the induction agents propofol and methohexitone on seizure duration and clinical outcome was assessed in a prospective, randomised, double blind study in 32 depressed patients receiving electroconvulsive therapy (ECT). Assessments comprised Hamilton rating scales pre-ECT, weekly during the course, and at one month follow-up. Patients showed a significant improvement in depression as measured by the Hamilton rating scale across the course of the ECT treatment. This improvement was not significantly different in the propofol and methohexitone groups. Nor was the amount of improvement related to either the total duration of seizure experienced by the patient during the ECT series or the use of tricyclic antidepressants by some patients.

Finding Talent Among Elementary English Learners: A Validity Study of the HOPE Teacher Rating Scale

2021 ◽  
pp. 001698622098594
Author(s):  
Nielsen Pereira
Keyword(s):  
English Language Learners ◽  
English Learners ◽  
English Language ◽  
Rating Scales ◽  
Rating Scale ◽  
Teacher Rating ◽  
Esl Teachers ◽  
Invariance Testing ◽  
Scale Scores ◽  
The One

The purpose of this study was to investigate the validity of the HOPE Scale for identifying gifted English language learners (ELs) and how classroom and English as a second language (ESL) teacher HOPE Scale scores differ. Seventy teachers completed the HOPE Scale on 1,467 students in grades K-5 and four ESL teachers completed the scale on 131 ELs. Measurement invariance tests indicated that the HOPE Scale yields noninvariant latent means across EL and English proficient (EP) samples. However, confirmatory factor analysis results support the use of the scale with ELs or EP students separately. Results also indicate that the rating patterns of classroom and ESL teachers were different and that the HOPE Scale does not yield valid data when used by ESL teachers. Caution is recommended when using the HOPE Scale and other teacher rating scales to compare ELs to EP students. The importance of invariance testing before using an instrument with a population that is different from the one(s) for which the instrument was developed is discussed.

scholarly journals Diagnosis Based on Parent and Teacher Rating for Attention Deficit Hyperactivity Disorder

JMS SKIMS ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 11-14
Author(s):  
Abdul Rouf ◽  
Shabnum Rivees ◽  
A Wahid Khan ◽  
A G Madhosh ◽  
Zeba Zeba
Keyword(s):  
Attention Deficit ◽  
Rating Scales ◽  
Rating Scale ◽  
Teacher Rating ◽  
Parent Rating ◽  
Four Dimensions ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Adhd Children ◽  
Icd 10

Parents and teachers play a significant role in the diagnosis of ADHD in children in the clinical setting. With the same in consideration a study was conducted to compare the perception between parents and teachers on the rating scales for ADHD children. The study was conducted on a sample of parents and teachers of 100 children diagnosed as having ADHD as per ICD-10 diagnostic criteria. A newly constructed and standardized parent rating scale for parents of ADHD children and attention deficit comprehensive teacher rating scale for teachers was administered on the target sample. Results indicate that there was statistically no significant difference in the rating of perception between parents and teachers on four dimensions, viz (i) attention (ii) hyperactivity (iii) social skills (iv) oppositional behaviour of ADHD children. To verify these findings, positive correlation was found between parents and teachers perception on all the four dimensions.J Med Sci.2010;13(1);11-14

scholarly journals The Validity of Teacher Rating Scales for the Assessment of ADHD Symptoms in the Classroom: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 108705472091683
Author(s):  
Anouck I. Staff ◽  
Jaap Oosterlaan ◽  
Saskia van der Oord ◽  
Pieter J. Hoekstra ◽  
Karen Vertessen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Convergent Validity ◽  
Rating Scales ◽  
Rating Scale ◽  
Meta Analysis ◽  
Teacher Rating ◽  
Impulsive Behavior ◽  
Adhd Symptoms ◽  
Clinical Interviews ◽  
Scale Scores

Objective: To assess attention-deficit/hyperactivity disorder (ADHD) symptoms in the classroom, most often teacher rating scales are used. However, clinical interviews and observations are recommended as gold standard assessment. This systematic review and meta-analysis evaluates the validity of teacher rating scales. Method: Twenty-two studies ( N = 3,947 children) assessing ADHD symptoms using teacher rating scale and either semi-structured clinical interview or structured classroom observation were meta-analyzed. Results: Results showed convergent validity for rating scale scores, with the strongest correlations ( r = .55–.64) for validation against interviews, and for hyperactive–impulsive behavior. Divergent validity was confirmed for teacher ratings validated against interviews, whereas validated against observations this was confirmed for inattention only. Conclusion: Teacher rating scales appear a valid and time-efficient measure to assess classroom ADHD; although validated against semi-structured clinical interviews, there were only a few studies available. Low correlations between ratings and structured observations of inattention suggest that observations could add information above rating scales.

A Controlled Comparative Trial of a New Antidepressant, Ciclazindol

1979 ◽  
Vol 7 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sidney Levine
Keyword(s):  
Rating Scale ◽  
Comparative Trial ◽  
Poor Response ◽  
Endogenous Depression ◽  
Depressive Illness ◽  
Double Blind ◽  
Significant Difference ◽  
Severity Of Depression ◽  
The Mean ◽  
Rate Of Response

The author describes a controlled, double-blind, comparative trial of a new tetracyclic compound, ciclazindol (WY 23409), against amitriptyline in the treatment of thirty-five patients admitted to hospital with depressive illness. Each patient was randomly allocated to three weeks treatment with either 50 mg b.d. ciclazindol or 50 mg b.d. amitriptyline. In the event of a poor response the dose level was raised to 75 mg b.d. Separation of cases of endogenous depression and severity of depression were assessed by the Levine-Pilowsky Depression Questionnaire, a self-rating technique. Severity of depression was also assessed using the Hamilton Rating Scale. No significant difference was noted between the drugs in either the degree or the rate of response nor when the endogenous cases alone were studied. The interesting observation was made that only one-third of ciclazindol patients gained weight compared to almost three-quarters of the amitriptyline group and the mean weight gain of the latter was over double that of the ciclazindol group. The author concludes that ciclazindol offers promise and merits further study using higher dosage levels once its full safety trials have been completed.

Effects of ECT on Prolactin, LH, FSH and Testosterone in Males with Major Depressive Illness*

1989 ◽  
Vol 34 (8) ◽  
pp. 814-817 ◽  
Author(s):  
A.J. Cooper ◽  
R. Finlayson ◽  
V.R. Velamoor ◽  
R.V. Magnus ◽  
Z. Cernovsky
Keyword(s):  
Luteinizing Hormone ◽  
Sexual Functioning ◽  
Rating Scale ◽  
Follicle Stimulating Hormone ◽  
Depressive Illness ◽  
Serum Prolactin ◽  
Major Depressive ◽  
Treatment Changes ◽  
Severity Of Depression ◽  
Hamilton Rating Scale

Fourteen males with major depressive illness (DSM-III) received a course of electroconvulsive therapy (ECT). Serum prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T), were measured 15 minutes before and 15 minutes after each treatment. The severity of depression was assessed with the Hamilton Rating Scale for Depression (HRSD) two to three days before the first and two to three days following the last treatment. Post-ECT levels of PRL and LH were significantly higher than pre-ECT levels across every treatment. Changes in FSH and testosterone were not significant. There were no relationships between hormone levels (first versus last ECT) and severity of depression, including sexual functioning. It is argued that the relatively greater increases of LH than FSH is due to an acute antidopaminergic action of ECT which acts selectively on the secretion of the former. The blunted testosterone response to the increase of gonadotropins may be due to ECT-induced hyperprolactinemia.

Depression in Inpatients: Bipolar vs Unipolar

2003 ◽  
Vol 92 (3) ◽  
pp. 1031-1039 ◽  
Author(s):  
Stella Dorz ◽  
Giuseppe Borgherini ◽  
Donatella Conforti ◽  
Caterina Scarso ◽  
Guido Magni
Keyword(s):  
Social Support ◽  
Major Depression ◽  
Social Adjustment ◽  
Rating Scales ◽  
Rating Scale ◽  
Social Impairment ◽  
Symptom Checklist ◽  
Bipolar Patients ◽  
Hamilton Rating Scale ◽  
Social Adjustment Scale

162 depressed inpatients were divided into three diagnostic groups to compare patterns of sociodemographic characteristics, psychopathology, and psychosocial: 35 had a single episode of major depression, 96 had recurrent major depression, and 31 had a bipolar disorder. Psychopathology and psychosocial functioning were measured by clinician-rated scales, Montgomery-Asberg Depression Rating Scale, Hamilton Rating Scale for Depression, Clinical Global Impression, and self-rating scales, Symptom Checklist-90, Social Support Questionnaire, Social Adjustment Scale. The three groups were comparable on sociodemographic variables, with the exception of education. Univariate analyses showed a similar social impairment as measured by Social Support Questionnaire, Social Adjustment Scale, and no significant differences were recorded for the psychopathology when the total test scores (Montgomery-Asberg Depression Rating Scale, Hamilton Rating Scale for Depression, Clinical Global Index, Symptom Checklist-90) were evaluated. Some differences emerged for single items in the Montgomery-Asberg Depression Rating Scale and Symptom Checklist-90. These findings suggest a substantial similarity among the three groups. Results are discussed in terms of the clinical similarities between unipolar and bipolar patients during a depressive episode as well as the limitations of cross-sectional study implies.

scholarly journals Timely Interventions for Children with ADHD through Web-Based Monitoring Algorithms

Diseases ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 20 ◽  
Author(s):  
Julia Oppenheimer ◽  
Oluwafemi Ojo ◽  
Annalee Antonetty ◽  
Madeline Chiujdea ◽  
Stephanie Garcia ◽  
...  
Keyword(s):  
Patient Monitoring ◽  
Rating Scales ◽  
Rating Scale ◽  
Care Plan ◽  
Web Based ◽  
Face To Face ◽  
Hyperactivity Disorder ◽  
Scale Scores ◽  
Patient Monitoring System ◽  
Trigger Algorithm

The aim of this study was to evaluate an automated trigger algorithm designed to detect potentially adverse events in children with Attention-Deficit/Hyperactivity Disorder (ADHD), who were monitored remotely between visits. We embedded a trigger algorithm derived from parent-reported ADHD rating scales within an electronic patient monitoring system. We categorized clinicians’ alert resolution outcomes and compared Vanderbilt ADHD rating scale scores between patients who did or did not have triggered alerts. A total of 146 out of 1738 parent reports (8%) triggered alerts for 98 patients. One hundred and eleven alerts (76%) required immediate clinician review. Nurses successfully contacted parents for 68 (61%) of actionable alerts; 46% (31/68) led to a change in care plan prior to the next scheduled appointment. Compared to patients without alerts, patients with alerts demonstrated worsened ADHD severity (β = 5.8, 95% CI: 3.5–8.1 [p < 0.001] within 90 days prior to an alert. The trigger algorithm facilitated timely changes in the care plan in between face-to-face visits.

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