Impotence: Prognosis (A Controlled Study)

SummarySixty-five patients primarily referred for erectile impotence were investigated and treated in a psychiatric out-patient department. Information was obtained from patients and wherever possible from their partners. Subjects were treated either with chemotherapy or with a modified form of Masters and Johnson's technique. A controlled group were not given any specific treatment. Results indicated that neither chemotherapy or behaviour modification (modified Masters and Johnson's technique) were in any way superior to no treatment. The prognosis was related to the clinical features of the subjects rather than to the form of treatment. Subjects in whom impotence was caused by a specific psychological or physical trauma showed a much better prognosis than those who had an insidious decline in sexual potency without any discernible psychological or physical factors. The decline in these latter subjects with a very poor prognosis was possibly due to inherent physiological factors.

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SAT0145 Efficacy and Safety of Sirukumab in Patients with Active Rheumatoid Arthritis despite Disease-Modifying Anti-Rheumatic Drug Treatment: Results of A Randomized, Double-Blind, Placebo-Controlled Study: Table 1.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.3741 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 717.1-717

Author(s):

T. Takeuchi ◽

C. Thorne ◽

G. Karpouzas ◽

S. Sheng ◽

W. Xu ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Drug Treatment ◽

Active Rheumatoid Arthritis ◽

Controlled Study ◽

Efficacy And Safety ◽

Treatment Results ◽

Double Blind ◽

Double Blind Placebo ◽

Disease Modifying ◽

Rheumatic Drug

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Safety and efficacy of herbal medicine for acute intracerebral hemorrhage (CRRICH): a multicentre randomised controlled trial

BMJ Open ◽

10.1136/bmjopen-2018-024932 ◽

2019 ◽

Vol 9 (5) ◽

pp. e024932 ◽

Cited By ~ 4

Author(s):

Liling Zeng ◽

Guanghai Tang ◽

Jing Wang ◽

Jianbin Zhong ◽

Zhangyong Xia ◽

...

Keyword(s):

Placebo Group ◽

Herbal Medicine ◽

Adverse Events ◽

Intracerebral Haemorrhage ◽

Poor Prognosis ◽

Controlled Trial ◽

Blood Stasis ◽

Secondary Outcome ◽

Controlled Study ◽

Safety And Efficacy

ObjectiveTo evaluate the safety and efficacy of removing blood stasis (RBS) herbal medicine for the treatment of acute intracerebral haemorrhage (AICH) within a 6-hour time window.Study designA randomised, multicentre, double-blind, placebo-controlled study performed in 14 hospitals in China.Participants and interventionsPatients with AICH were randomly assigned to receive a placebo, the ICH-1 (Intracerebral Haemorrhage) formula (eight herbs, including the RBS herbs hirudo and tabanus) or the ICH-2 formula (six herbs without the RBS herbs hirudo and tabanus) within 6 hours of ICH onset.OutcomesThe primary safety outcome was the incidence of haematoma enlargement at 24 hours and at 10 days after treatment. The secondary outcome was the incidence of poor prognosis (mortality or modified Rankin Scale score ≥5) assessed at 90 days after symptom onset.ResultsA total of 324 subjects were randomised between October 2013 and May 2016: 105 patients received placebo; 108 patients received the ICH-1 formula; and 111 patients received the ICH-2 formula. The incidence of haematoma enlargement at 24 hours was 7.8% in the placebo group, 12.3% in the ICH-1 group and 7.5% in the ICH-2 group; the incidence of haematoma enlargement on day 10 was 1.1% in the placebo group, 1.1% in the ICH-1 group, and 3.1% in the ICH-2 group, with no significant differences among the groups (P>0.05). The mortality rates were 3.8% in the placebo group, 2.8% in the ICH-1 group, and 0.9% in the ICH-2 group; the incidences of poor prognosis were 7.1% in the placebo group, 6.0% in the ICH-1 group and 4.8% in the ICH-2 group at 3 months, with no significant differences among the groups (p>0.05). However, the overall frequency of treatment-emergent adverse events in the ICH-1 group (12.1%) was higher among the three groups (5.8% and 2.8%, respectively, p<0.05). All three cases of serious adverse events were in the ICH-1 group.ConclusionsUltra-early administration of ICH-1 formula for AICH patients did not exert significant beneficial effects on clinical outcomes but increased the risk of bleeding, which probably resulted from the inclusion of RBS herbal medicines in ICH-1.Trialregistration numberNCT01918722.

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Sustained Efficacy of Eszopiclone Over 6 Months of Nightly Treatment: Results of a Randomized, Double-Blind, Placebo-Controlled Study in Adults with Chronic Insomnia

SLEEP ◽

10.1093/sleep/26.7.793 ◽

2003 ◽

Vol 26 (7) ◽

pp. 793-799 ◽

Cited By ~ 302

Author(s):

Andrew D. Krystal ◽

James K. Walsh ◽

Eugene Laska ◽

Judy Caron ◽

David A. Amato ◽

...

Keyword(s):

Chronic Insomnia ◽

Controlled Study ◽

Treatment Results ◽

Double Blind ◽

Double Blind Placebo ◽

Sustained Efficacy

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Lymphedema in Klippel-Trenaunay Syndrome: Is It Possible to Normalize?

Case Reports in Vascular Medicine ◽

10.1155/2016/5230634 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4

Author(s):

Jose Maria Pereira de Godoy ◽

Angela Río ◽

Paloma Domingo Garcia ◽

Maria de Fatima Guerreiro Godoy

Keyword(s):

Intensive Therapy ◽

Specific Treatment ◽

Clinical History ◽

Port Wine ◽

Water Displacement ◽

Treatment Results ◽

Her Family ◽

Patient Reported ◽

Cervical Stimulation ◽

Klippel Trenaunay Syndrome

The aim of this study is to report the results of intensive therapy of lymphedema associated with Klippel-Trenaunay syndrome. A 24-year-old female patient reported that her family had observed edema in her right leg and port wine stains from birth. For ten years, they consulted with different specialists in the region but the prognosis did not change and no specific treatment was found. In 2014, at the age of 24, with massive lymphedema, a leg ulcer, and recurrent infections, she started treatment at the Clínica Godoy in São José do Rio Preto. She was evaluated by clinical history, physical examination, water displacement volumetry, and bioimpedance. Intensive therapy (8 hours daily) was proposed using Manual Lymphatic Therapy (Godoy & Godoy), Cervical Stimulation Therapy, Mechanical Lymphatic Therapy, a grosgrain stocking adjusted several times a day, and the use of Unna boot in the region of the ulcer. The volume of edema was reduced by about 44% within the first week with further reductions in the following weeks and healing of the ulcer. Subsequently, it was possible to control and maintain the reduction in swelling with less intense treatment. It is possible to reduce and maintain the treatment results of lymphedema associated with Klippel-Trenaunay syndrome.

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A placebo-controlled study investigating the dexamethasone-sparing effects of corticorelin acetate in patients with primary or metastatic brain tumors and peritumoral edema

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.2078 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 2078-2078

Author(s):

L. D. Recht ◽

L. Mechtler ◽

S. Phuphanich ◽

A. Hormigo ◽

V. Hines ◽

...

Keyword(s):

Dose Reduction ◽

Subcutaneous Tissue ◽

Performance Status ◽

Specific Treatment ◽

Lower Limbs ◽

Controlled Study ◽

Peritumoral Edema ◽

Cerebral Tumors ◽

Proximal Myopathy

2078 Background: The standard therapy for patients with peritumoral edema (PTE) associated with cerebral tumors is long-term dexamethasone (dex), which is associated with significant short- and long-term adverse events (AEs). Corticorelin acetate (CrA) is a synthetic peptide of corticotropin-releasing factor that may have the potential to allow such patients to reduce or stop dex therapy. This study investigated the steroid-sparing effect of CrA in patients with cerebral tumors and PTE. Methods: Patients were randomized to CrA 1.0 mg bid SC (n = 100) or placebo (PLA) SC (n = 100) for 12 weeks. The primary endpoint was the percentage of responders, defined as patients able to reduce their daily dex dose by ≥50% by week 2 and maintain this reduction until week 5, without deterioration in neurologic or performance status. Secondary endpoints included maximum percent dex dose reduction from baseline and proximal myopathy (Kendall Myopathy Scale). Steroid-specific treatment-emergent AEs (TEAEs) were also evaluated. Results: The groups were comparable at baseline. There were more responders in the CrA arm vs the PLA arm (62/100 vs. 47/100; p = 0.03). A maximum dex dose reduction of ≥75% was achieved by 42% of CrA patients vs 22% of PLA patients (p = 0.01). 15% of CrA patients were able to stop dex vs. 6% PLA (p = 0.04). At week 12 vs. baseline, proximal myopathy was improved in the CrA group vs the PLA group for upper limbs (p = 0.06) and lower limbs (p = 0.02). AE profiles in both groups were dominated by dex-associated side effects. The overall AE profiles of the treatment groups were generally similar. Emergent cushingoid signs were seen in 13 PLA vs 2 CrA patients (p = 0.01); 14 PLA patients reported skin/subcutaneous tissue disorders as TEAEs vs. 7 CrA patients (p = 0.07). Conclusions: CrA may benefit patients with symptoms of PTE associated with primary or metastatic cerebral tumors by allowing them to reduce/stop their dex treatment, so reducing the incidence of the steroid-related AEs of myopathy, cushingoid symptoms, and skin disorders. [Table: see text]

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P.2.093 Marked increase in adiposity during olanzapine vs risperidone treatment: Results of a placebo-controlled study in normal dogs

European Neuropsychopharmacology ◽

10.1016/s0924-977x(03)92046-3 ◽

2003 ◽

Vol 13 ◽

pp. S320-S321

Author(s):

M. Ader ◽

S.P. Kim ◽

K.J. Catalano ◽

V. Ionut ◽

K. Hucking ◽

...

Keyword(s):

Controlled Study ◽

Treatment Results ◽

Risperidone Treatment

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Systematic Desensitization of Erectile Impotence: A Controlled Study

Handbook of Sex Therapy - Perspectives in Sexuality ◽

10.1007/978-1-4613-3973-1_26 ◽

1978 ◽

pp. 337-343

Author(s):

G. Kockott ◽

F. Dittmar ◽

L. Nusselt

Keyword(s):

Controlled Study ◽

Systematic Desensitization ◽

Erectile Impotence

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A Randomized Controlled Study of a Cognitive Behavioral Planning Intervention for College Students With ADHD: An Effectiveness Study in Student Counseling Services in Flanders

Journal of Attention Disorders ◽

10.1177/1087054718787033 ◽

2018 ◽

Vol 24 (6) ◽

pp. 849-862 ◽

Cited By ~ 1

Author(s):

S. Van der Oord ◽

B. E. Boyer ◽

Lotte Van dyck ◽

K. J. Mackay ◽

H. De Meyer ◽

...

Keyword(s):

College Students ◽

Intervention Group ◽

Specific Treatment ◽

Cognitive Behavioral ◽

Controlled Study ◽

Counseling Services ◽

Treatment Needs ◽

Student Counseling ◽

Planning Intervention

Objective: The effectiveness of a short (six session) individual cognitive behavioral planning intervention for college students with attention-deficit/hyperactivity disorder (ADHD) was tested. Method: In three student counseling services in Flanders, individuals with ADHD ( N = 58) were randomized to the intervention or waitlist condition. Pre- and posttreatment assessments were conducted, and within the intervention group, a 4-month follow-up was conducted. Primary outcomes were ADHD symptoms and study skills; secondary outcomes were comorbid symptoms and planning skills on a neuropsychological task. Results: Intent-to-treat analyses showed a significant interaction on one outcome: inattention symptoms. The treatment condition improved from pretest to posttest, whereas the waitlist did not. Other measures showed large significant time effects (improved skills, reduction of symptoms in both groups) but no interactions. Stability analyses were not possible due to substantial dropout at follow-up. Conclusion: Specific treatment effects are on one outcome (inattention) and modest; for further implementation, the treatment needs adaptation.

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