Amphetamine-Induced Dysphoria in Postmenopausal Women

SummaryDextroamphetamine (0.15 mg/kg) intravenously administered to a group of normal postmenopausal women induced a dysphoric reaction with drowsiness, annoyance, sadness and anger. Young normal men, receiving the same dosage, responded with elation of mood and alertness. It is suggested that age and hypoestrogenism may alter the behavioural response to amphetamine.

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IMMUNOASSAY OF FOLLICLE-STIMULATING HORMONE IN HUMAN URINE AND SERUM BY QUANTITATIVE COMPLEMENT FIXATION

Journal of Endocrinology ◽

10.1677/joe.0.0420055 ◽

1968 ◽

Vol 42 (1) ◽

pp. 55-63 ◽

Cited By ~ 7

Author(s):

K. F. MORI

Keyword(s):

Postmenopausal Women ◽

Human Urine ◽

Complement Fixation ◽

Follicle Stimulating Hormone ◽

Human Urine And Serum ◽

The Mean ◽

Normal Men ◽

Urine And Serum ◽

Urinary Fsh ◽

Stimulating Hormone

SUMMARY An immunoassay method for follicle-stimulating hormone (FSH) in human urine and serum by means of complement fixation is described in detail. The assay detects 0·6–1·5 m-u. FSH, and does not require any modification of antigens. Good agreement is shown between the biological and immunological estimations of FSH activity of urinary and serum extracts. Immunological estimations of the urinary FSH excretion in 15 normal men and 24 normal postmenopausal women gave the mean values of 8·5 (range 2·6–15·4) i.u. and 116·7 (range 30·1–213·3) i.u./24 hr., respectively. The mean serum FSH levels determined immunologically in ten normal men and 14 normal postmenopausal women were 6·2 (range 3·3–13·9) m-u. and 58·1 (range 39·7–94·0) m-u./ml., respectively. The pattern of daily urinary FSH excretion during the menstrual cycle of a normal woman showed an insignificant rise during the follicular phase and a peak immediately after the thermal nadir.

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Serum-free estradiol (E2) levels are prognostic in men with chemotherapy-naive advanced non-small cell lung cancer (NSCLC) and performance status (PS) 2

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.7683 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 7683-7683 ◽

Cited By ~ 4

Author(s):

H. Ross ◽

F. B. Oldham ◽

B. Bandstra ◽

L. Sandalic ◽

J. Bianco ◽

...

Keyword(s):

Postmenopausal Women ◽

Advanced Nsclc ◽

Performance Status ◽

High Serum ◽

Phase Iii ◽

Rank Test ◽

Serum Free ◽

Male Patients ◽

And Performance ◽

Normal Men

7683 Background: In women with advanced NSCLC, premenopausal estradiol levels are associated with a worse survival than postmenopausal levels, suggesting an adverse effect of estradiol on prognosis in NSCLC (JCO 2006, 24(18S):7038; JCO 2006, 24:59–63). Levels of E2, produced from testosterone by aromatase, are often higher in men than in postmenopausal women (Ann Intern Med. 2000, 133:951–63). To investigate the effect of E2 on prognosis in male patients (pts) with advanced NSCLC, total and free E2 levels were assayed in pretreatment samples from men participating in 2 randomized phase III studies, STELLAR 3 and 4. Methods: Free serum E2 levels were measured prior to chemotherapy using a radioimmuno-assay in samples from 289/307 male pts with advanced NSCLC and PS2 enrolled in STELLAR 3 (paclitaxel + carboplatin (C) v. paclitaxel poliglumex (PPX) + C) and STELLAR 4 (vinorelbine or gemcitabine v. PPX). The effect of free E2 levels on survival was evaluated by log rank test. Male pts were categorized as high or low E2 based on values above or below the median (0.42 pg/ml; range: 0.1–2.95).The assay range for normal men is 0.2 - 0.5 pg/ml; in pre- and postmenopausal women, the range is 0.80- 3.45 and 0.12 - 0.39 pg/ml, respectively. Results: Hazard ratio's (HR), median, and 1-yr survival are summarized in the table . Survival was worse for male pts with E2 values higher than the median compared to those below the median (HR 1.56, p = .0008). This difference in survival was not dependent on treatment arm as survival was similar for male pts > 0.42 pg/ml receiving either PPX or control. Conclusions: High serum free E2 levels are associated with shorter survival in men with advanced NSCLC, consistent with the shorter survival noted in NSCLC in premenopausal compared to older women. While PPX is associated with improved survival in women with premenopausal E2 levels (JCO 2006, 24(18S):7039), the relatively low levels of E2 in men may be insufficient to affect survival in male pts receiving PPX. [Table: see text] [Table: see text]

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Radioimmunoassay of Serum Estrogen

Clinical Chemistry ◽

10.1093/clinchem/19.7.740 ◽

1973 ◽

Vol 19 (7) ◽

pp. 740-747 ◽

Cited By ~ 17

Author(s):

Nai-Siang Jiang ◽

Robert J Ryan ◽

A Albert

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Postmenopausal Women ◽

Bovine Serum ◽

Normal Men ◽

Estradiol 17Β ◽

Fertile Women

Abstract Radioimmunoassay of serum estrogen (sum of estrone and estradiol-17β) in 0.5 ml of human serum is described. After dilution of the serum, the estrogens are adsorbed on a Sephadex G-15 column in the presence of dilute HCl and then eluted with benzene. After evaporation of the benzene eluate, the estrogens are dissolved in bovine serum albumin (5 g/ liter solution, at pH 8.0). An aliquot of this solution is used for the assay. Serum estrogen concentrations (mean ± SD) were 69 ± 23 pg/ml in 105 normal men and 199 ± 146 pg/ml in 26 fertile women. In 109 postmenopausal women, estrogen was undetectable in seven sera, but in the remaining 102 it was 52 ± 30 pg/ml of serum.

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Effect of Melatonin on the Basal and Stimulated Gonadotropin Levels in Normal Men and Postmenopausal Women

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-42-6-1014 ◽

1976 ◽

Vol 42 (6) ◽

pp. 1014-1017 ◽

Cited By ~ 11

Author(s):

HUGO FIDELEFF ◽

NÉSTOR J. APARICIO ◽

ABRAHAM GUITELMAN ◽

LUCIANO DEBELJUK ◽

ANTONIO MANCINI ◽

...

Keyword(s):

Postmenopausal Women ◽

Normal Men

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Estrone sulfate concentrations in plasma of normal individuals, postmenopausal women with breast cancer, and men with cirrhosis.

Clinical Chemistry ◽

10.1093/clinchem/29.1.86 ◽

1983 ◽

Vol 29 (1) ◽

pp. 86-89 ◽

Cited By ~ 19

Author(s):

A Rémy-Martin ◽

O Prost ◽

M Nicollier ◽

J Burnod ◽

G L Adessi

Keyword(s):

Breast Cancer ◽

Postmenopausal Women ◽

Luteal Phase ◽

Mean Value ◽

Follicular Phase ◽

Enzymic Hydrolysis ◽

Estrone Sulfate ◽

Normal Individuals ◽

The Mean ◽

Normal Men

Abstract Estrone sulfate is quantitatively the most important estrogen in plasma. A method for its determination in human plasma is described, and the precision, accuracy, sensitivity, and specificity are defined. Free steroids were extracted from plasma with diethyl ether and steroid sulfates were isolated with use of Vlitos' reagent (methylene blue in dilute H2SO4/Na2SO4 solution). After enzymic hydrolysis, estrone was isolated by chromatography on Celite and measured by radioimmunoassay. The mean concentrations (nmol/L +/- 1 SD) of estrone sulfate were 2.51 +/- 0.90 for plasma from 13 women in follicular phase, 5.33 +/- 1.55 for 17 women in luteal phase, 0.89 +/- 0.60 for 44 postmenopausal women, and 0.96 +/- 0.43 for 24 postmenopausal women with breast cancer. Results for postmenopausal women with or without breast cancer did not differ significantly. For 13 normal men, estrone sulfate concentrations were 2.62 +/- 0.79 nmol/L, and for a group of 19 cirrhotic men the mean value was 1.43 +/- 0.95 nmol/L, significantly lower than normal.

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