Patients' Perceptions of Family Emotional Climate and Outcome in Schizophrenia

1993 ◽  
Vol 162 (6) ◽  
pp. 751-754 ◽  
Author(s):  
Malca B. Lebell ◽  
Stephen R. Marder ◽  
Jim Mintz ◽  
Lois I. Mintz ◽  
Martha Tompson ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Rating Scales ◽  
Survival Rates ◽  
Emotional Climate ◽  
Chronic Schizophrenic ◽  
Frequent Contact ◽  
Patients At Risk ◽  
One Year ◽  
Psychotic Exacerbation

Thirty-nine chronic schizophrenic male out-patients and their relatives were interviewed separately to assess their perceptions of their current relationships. Two simple 5-point rating scales predicted the risk of psychotic exacerbation during a one-year follow-up: patients' perceptions of the relatives' attitudes towards them, and patients' own attitudes towards the relatives. Survival analysis of data in a 2 × 2 factorial - combining degree of contact with the key relatives and the patients' perceptions of their relatives - found that patients in frequent contact with a positively perceived relative had significantly better survival rates without psychotic exacerbation. Patients' perceptions of their relatives may help identify patients at risk of exacerbation of their illness.

Mentoring to Promote Professional Well-being

Relay Journal ◽  
2019 ◽  
pp. 306-318
Author(s):  
Hatice Karaaslan
Keyword(s):  
Positive Emotions ◽  
Well Being ◽  
Research Experience ◽  
Reflective Dialogue ◽  
Frequent Contact ◽  
Depth Analysis ◽  
Junior Colleague ◽  
One Year ◽  
Personal Reflections

This article elaborates on a follow-up mentoring session conducted with a junior colleague who had frequent contact with me over a period of one year during her coursework as she considered me a senior instructor with substantial research experience. The purpose was to exploit the strategies of advising in a mentoring context utilizing intentional reflective dialogue (IRD) to encourage reflection on professional well-being. To facilitate the process and achieve an in-depth analysis of her level of professional well-being, I employed Seligman’s (2011) PERMA model, explaining professional well-being with reference to its components of positive emotions, engagement, relationships, meaning, and accomplishment. In the article, I briefly give information on the context and background, the purpose, and the professional well-being model used. I then outline the flow of the session, and point out and discuss how the strategies of advising have been exploited through a series of IRD exchanges in an effort to stimulate an in-depth discussion. Finally, I present my personal reflections as well as the potential implications to be considered while conducting mentor-mentee sessions and improving professional well-being in educational settings.

scholarly journals One-year outcomes of microhook trabeculotomy versus suture trabeculotomy ab interno

2021 ◽  
Author(s):  
Hiroshi Yokoyama ◽  
Masashi Takata ◽  
Fumi Gomi
Keyword(s):  
Survival Analysis ◽  
Clinical Success ◽  
Treatment Success ◽  
Medication Use ◽  
Glaucoma Surgery ◽  
Success Rates ◽  
Kaplan Meier ◽  
One Year ◽  
Ab Interno

Abstract Purpose To compare clinical success rates and reductions in intraocular pressure (IOP) and IOP-lowering medication use following suture trabeculotomy ab interno (S group) or microhook trabeculotomy (μ group). Methods This retrospective review collected data from S (n = 104, 122 eyes) and μ (n = 42, 47 eyes) groups who underwent treatment between June 1, 2016, and October 31, 2019, and had 12-month follow-up data including IOP, glaucoma medications, complications, and additional IOP-lowering procedures. The Kaplan–Meier survival analysis was used to evaluate treatment success rates defined as normal IOP (> 5 to ≤ 18 mm Hg), ≥ 20% reduction of IOP from baseline at two consecutive visits, and no further glaucoma surgery. Results Schlemm’s canal opening was longer in the S group than in the μ group (P < 0.0001). The Kaplan–Meier survival analysis of all eyes showed cumulative clinical success rates in S and µ groups were 71.1% and 61.7% (P = 0.230). The Kaplan–Meier survival analysis of eyes with preoperative IOP ≥ 21 mmHg showed cumulative clinical success rates in S and μ groups were 80.4% and 60.0% (P = 0.0192). There were no significant differences in postoperative IOP at 1, 3, and 6 months (S group, 14.9 ± 5.6, 14.6 ± 4.5, 14.6 ± 3.9 mmHg; μ group, 15.8 ± 5.9, 15.2 ± 4.4, 14.7 ± 3.7 mmHg; P = 0.364, 0.443, 0.823), but postoperative IOP was significantly lower in the S group at 12 months (S group, 14.1 ± 3.1 mmHg; μ group, 15.6 ± 4.1 mmHg; P = 0.0361). There were no significant differences in postoperative numbers of glaucoma medications at 1, 3, 6, and 12 months (S group, 1.8 ± 1.6, 1.8 ± 1.5, 2.0 ± 1.6, 1.8 ± 1.5; μ group, 2.0 ± 1.6, 2.0 ± 1.6, 2.1 ± 1.6, 2.2 ± 1.7; P = 0.699, 0.420, 0.737, 0.198). Conclusion S and µ group eyes achieved IOP reduction, but μ group eyes had lower clinical success rates among patients with high preoperative IOP at 12 months.

scholarly journals Immediate Implant Placement by Interradicular Bone Drilling before Molar Extraction: Clinical Case Report with One-Year Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Stuardo Valenzuela ◽  
José M. Olivares ◽  
Nicolás Weiss ◽  
Dafna Benadof
Keyword(s):  
Survival Rates ◽  
Three Dimensional ◽  
Primary Stability ◽  
Bone Drilling ◽  
Implant Placement ◽  
Immediate Implants ◽  
Immediate Implant ◽  
One Year ◽  
Molar Extraction

The placement of immediate implants in the posterior sector is a widespread procedure where the success and survival rates are similar to those of traditional protocols. It has several anatomical challenges, such as the presence of interradicular bone septa that hinder a correct three-dimensional positioning of the implant and may compromise primary stability and/or cause damage of neighboring structures. The aim of this article is to present the treatment and the one-year clinical follow-up of a patient who received immediate implant placement using an interradicular bone-drilling technique before the molar extraction.

Incidence and characterization of venous thromboembolic events (VTE) in patients with pancreatic cancer: Effect of timing of VTE on survival.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 4037-4037
Author(s):  
Maithili A Shethia ◽  
Aparna Hegde ◽  
Xiao Zhou ◽  
Michael J. Overman ◽  
Saroj Vadhan-Raj
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Survival Analysis ◽  
Kaplan Meier ◽  
Hazard Ratios ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic ◽  
One Year ◽  
The Impact

4037 Background: Patients (pts) with pancreatic cancer are at high risk for VTE, and the occurrence of VTE can affect pts’ prognosis. The purpose of this study was to evaluate the incidence of VTE and the impact of timing of VTE (early vs. late) on survival. Methods: Medical record of 260 pts with pancreatic cancer, newly referred to UT MDACC during one year period from 1/1/2006 to 12/31/2006, were reviewed for the incidence of VTE during a 2-year follow-up period from the date of diagnosis. All VTE episodes were confirmed by radiologic studies. Survival analysis was conducted using Kaplan-Meier analysis and Cox proportional hazard models. Results: Of the 260 pts, 47 pts (18%) had 51 episodes of VTE during the 2-year follow-up. The median age of the pts with VTE was 61 years (range: 28-86) and 53% were males. Of the 47 pts with VTE, 27 (57%) had PE, 19 (40%) had DVT and 1 had concurrent PE/DVT. Three pts had recurrent VTE during the study period. Median follow-up time for OS was 192 days (range: 1-1652 days). Kaplan-Meier Survival analysis showed that those who developed VTE earlier (within 30 or 90 days) had shorter median overall survival (OS) compared with those who had VTE beyond these time points. The hazard ratios, 95% CI, and median OS at 1 year are summarized in the table below. Conclusions: The incidence of VTE is high in pts with pancreatic cancer. The timing of VTE had a significant impact on OS; pts who had an early development of VTE had a shorter overall survival. [Table: see text]

Symptom stability in geriatric chronic schizophrenic inpatients: A one-year follow-up study

1996 ◽  
Vol 39 (2) ◽  
pp. 92-99 ◽  
Author(s):  
Katherine M. Putnam ◽  
Philip D. Harvey ◽  
Michael Parrella ◽  
Leonard White ◽  
Margaret Kincaid ◽  
...  
Keyword(s):  
Chronic Schizophrenic ◽  
Follow Up Study ◽  
Symptom Stability ◽  
One Year

Prolonged prophylaxis against venous thromboembolism with enoxaparin in patients undergoing cancer surgery: long-term survival analysis

2006 ◽  
Vol 21 (4) ◽  
pp. 195-198 ◽  
Author(s):  
D Bergqvist ◽  
G Agnelli ◽  
A T Cohen ◽  
P E Nilsson ◽  
A Le Moigne-Amrani ◽  
...  
Keyword(s):  
Survival Rates ◽  
Palliative Surgery ◽  
Curative Surgery ◽  
Term Survival ◽  
Long Term Survival ◽  
Significant Difference ◽  
One Year ◽  
Type Of Surgery

Objective: ENOXACAN II was a randomized, double-blind trial that showed prolonged (four-week) thromboprophylaxis with enoxaparin to be more effective than and as safe as standard (one-week) thromboprophylaxis in patients undergoing surgery with a curative intent for abdominopelvic cancer. This follow-up study compared long-term, all-cause mortality in both groups. Methods: Survival rates were calculated on the randomized, treated population ( n = 501). The primary efficacy endpoint was survival at one year. An exploratory analysis including survival data up to 44 months was performed. Because some patients were deemed to have undergone palliative as opposed to curative surgery, and there was a significant difference between the treatment groups in the percentage of patients undergoing palliative surgery, the survival analyses were adjusted for the type of surgery performed. Results: When adjusted for type of surgery, there was a trend towards reduced mortality among patients undergoing palliative surgery in the prolonged prophylaxis group (hazard ratio [HR] = 0.598, P = 0.3565) that became more pronounced beyond the pre-specified one year follow-up period (HR = 0.469, P = 0.078). This trend may reflect a beneficial effect of prolonged prophylaxis on survival in the palliative surgery group (one-year survival 65.4 versus 50% for standard prophylaxis). In patients undergoing curative surgery, one-year survival rates were equal in the standard and prolonged prophylaxis groups (93.8 and 93.2%, respectively). Conclusion: Prolonged thromboprophylaxis with enoxaparin may affect long-term survival in palliative surgery for cancer, but further investigation is warranted.

scholarly journals Horizontal Bone Augmentation and Simultaneous Implant Placement using Xenogeneic Bone Rings Technique: A Retrospective Clinical Study

2020 ◽  
Author(s):  
Yude Ding ◽  
LianFei Wang ◽  
Kuiwei Su ◽  
Jinxing Gao ◽  
Xiao Li ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Survival Rates ◽  
Bone Grafts ◽  
Bone Defects ◽  
Bone Augmentation ◽  
Implant Placement ◽  
Retrospective Clinical Study ◽  
One Year ◽  
The One

Abstract Objectives: This study evaluated the use of bone ring technique with xenogeneic bone grafts in treating horizontal alveolar bone defects. Material and methods: In total, 11 patients in need of horizontal bone augmentation treatment before implant placement were included in this retrospective study. All patients received simultaneous bone augmentation surgery and implant placement with xenogeneic bone ring grafts. We evaluated the postoperative efficacy of the bone ring technique with xenogeneic bone grafts using radiographical and clinical parameters. Results: Survival rates of implants were 100%. Cone-beam computed tomography revealed that the xenogeneic bone ring graft had significantly sufficient horizontal bone augmentation below the implant neck platform to 0 mm, 1mm, 2mm, and 3mm. It could also provide an excellent peri-implant tissue condition during the one-year follow-up after loading. Conclusion: The bone ring technique with xenogeneic bone ring graft could increase and maintain horizontal bone mass in the region of the implant neck platforms in serious horizontal bone defects.

scholarly journals Protocol for Take home naloxone In Multicentre Emergency setting (TIME): Feasibility Study

2020 ◽  
Author(s):  
Matthew Jones ◽  
Fiona Bell ◽  
Jonathan Benger ◽  
Sarah Black ◽  
Penny Buykx ◽  
...  
Keyword(s):  
At Risk ◽  
Feasibility Study ◽  
Adverse Event Rate ◽  
Opioid Overdose ◽  
Emergency Setting ◽  
Risk Of Death ◽  
Emergency Ambulance ◽  
Patients At Risk ◽  
One Year

Abstract Background Opioids, such as heroin, kill more people worldwide by overdose than any other type of drug, and death rates associated with opioid poisoning in the UK are at record levels (1, 2). Naloxone is an opioid antagonist which can be distributed in ‘kits’ for administration by witnesses in an overdose emergency. This intervention is known as Take Home Naloxone (THN). We know that THN can save lives on an individual level, but there is currently limited evidence about the effectiveness of THN distribution on an aggregate level, in specialist drug service settings or in emergency service settings. Notably, we do not know whether THN kits reduce deaths from opioid overdose in at-risk populations, if there are unforeseen harms associated with THN distribution or if THN is cost-effective. In order to address this research gap, we aim to determine the feasibility of a fully-powered cluster Randomised Controlled Trial (RCT) of THN distribution in emergency settings. Methods We will carry out a feasibility study for a RCT of THN distributed in emergency settings at four sites, clustered by Emergency Department (ED) and catchment area within its associated ambulance service. THN is a peer-administered intervention. At two intervention sites, emergency ambulance paramedics and ED clinical staff will distribute THN to adult patients who are at risk of opioid overdose. At two control sites, practice will carry on as usual. We will develop a method of identifying a population to include in an evaluation, comprising people at risk of fatal opioid overdose, who may potentially receive naloxone included in a THN kit. We will gather anonymised outcomes up to one year following a 12 month ‘live’ trial period for patients at risk of death from opioid poisoning. We expect approximately 100 patients at risk of opioid overdose to be in contact with each service during the one year recruitment period. Our outcomes will include: deaths; emergency admissions; intensive care admissions; and ED attendances. We will collect numbers of eligible patients attended by participating emergency ambulance paramedics and attending ED; THN kits issued; and NHS resource usage. We will determine whether to progress to a fully-powered trial based on pre-specified progression criteria: sign-up of sites (n = 4); staff trained (>= 50%); eligible participants identified (>= 50%); THN provided to eligible participants (>= 50%); people at risk of death from opioid overdose identified for inclusion in follow up (>= 75% of overdose deaths); outcomes retrieved for high risk individuals (>= 75%); and adverse event rate (<10% difference between study arms).Discussion This feasibility study is the first randomised, methodologically robust investigation of THN distribution in emergency settings. The study addresses an evidence gap related to the effectiveness of THN distribution in emergency settings. As this study is being carried out in emergency settings, obtaining informed consent on behalf of participants is not feasible. We therefore employ novel methods for identifying participants and capturing follow up data, with effectiveness dependent on the quality of the available routine data.Trial registration ISRCTN13232859 (Registered 16/02/2018)

scholarly journals Low-dose decitabine for refractory prolonged isolated thrombocytopenia after HCT: a randomized multicenter trial

2021 ◽  
Vol 5 (5) ◽  
pp. 1250-1258
Author(s):  
Yaqiong Tang ◽  
Jia Chen ◽  
Qifa Liu ◽  
Tiantian Chu ◽  
Tingting Pan ◽  
...  
Keyword(s):  
Low Dose ◽  
Hematopoietic Cell Transplantation ◽  
Response Rate ◽  
Survival Rates ◽  
Multicenter Trial ◽  
Platelet Recovery ◽  
Underlying Mechanisms ◽  
One Year ◽  
To Receive

Abstract Refractory prolonged isolated thrombocytopenia (RPIT) is an intractable complication after allogeneic hematopoietic cell transplantation (HCT), which often leads to poor prognosis. A clinical study was designed to validate the efficacy and safety of low-dose decitabine for RPIT after HCT and explore the related underlying mechanisms. Eligible patients were randomly allocated to receive 1 of 3 interventions: arm A, low-dose decitabine (15 mg/m2 daily IV for 3 consecutive days [days 1-3]) plus recombinant human thrombopoietin (300 U/kg daily); arm B, decitabine alone; or arm C, conventional treatment. The primary end point was the response rate of platelet recovery at day 28 after treatment. Secondary end points included megakaryocyte count 28 days after treatment and survival during additional follow-up of 24 weeks. Among the 91 evaluable patients, response rates were 66.7%, 73.3%, and 19.4% for the 3 arms, respectively (P &lt; .001). One-year survival rates in arms A (64.4% ± 9.1%) and B (73.4% ± 8.8%) were similar (P = .662), and both were superior to that in arm C (41.0% ± 9.8%; P = .025). Megakaryocytes, endothelial cells (ECs), and cytokines relating to megakaryocyte migration and EC damage were improved in patients responding to decitabine. This study showed low-dose decitabine improved platelet recovery as well as overall survival in RPIT patients after transplantation. This trial was registered at www.clinicaltrials.gov as #NCT02487563.

scholarly journals P1688THE IMPACT OF KIDNEY DONOR PROFILE INDEX (KDPI) AND KIDNEY DONOR RISK INDEX (KDRI) ON KIDNEY TRANSPLANT FUNCTION: A MONOCENTRIC ANALYSIS AFTER ONE YEAR OF FOLLOW UP

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Andrea Solazzo ◽  
Giacomo Mori ◽  
Gianni Cappelli ◽  
Laura Tonelli ◽  
Francesca Facchini ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Kidney Transplant ◽  
Roc Curve ◽  
Risk Index ◽  
Statistical Correlation ◽  
Curve Analysis ◽  
Kidney Donor ◽  
Roc Curve Analysis ◽  
One Year

Abstract Background and Aims Evaluation of kidney donors is a complex process based on the elaboration of clinical, laboratory and imaging data. Until 2014, the quality of kidney transplant (KTx) was assessed considering standard donation criteria (SCD) or extended donation criteria (ECD). ECD kidneys (kECD) defined subjects older than 65 years without comorbidities or younger, but with comorbidities, such as hypertension, cerebral stroke, high creatinine level (above 1.5 mg/dL). The Kidney Donor Risk Index (KDRI) is an estimate of the relative risk of post-transplant kidney graft failure from a particular deceased donor compared to a reference donor. The value obtained is than converted in a percentage called KDPI (KDPI ≥85% is considered as similar of a kidney from ECD), which represent the percentage of utilized donor in the last year better than the considered. Italian experience in Donor Cardiac Death (DCD) is growing and doubled last KTx year, reaching 1.1 pmp in 2018, with the 22.5% of donors procured at our center. Our DCD KTx protocol has been active since November 2017, with promising results. We considered only controlled DCD (cDCD) Maastricht Class III. Methods We compared all DCD and DBD KTx performed in the Nephrology Unit of the University Hospital of Modena, Italy, from November 2017 to December 2018. We excluded living donor transplantation and combined liver–kidney transplantation. In this study, only cDCD are considered. We studied KDPI and KDRI score for both DBD and DCD KTx . Comparison between data from DCD and DBD was performed with t – Student and Chi Square test, survival analysis according to Kaplan-Meier and a Pearson correlation between KPI-KDRI and one year graft function was elaborated. ROC curve analysis was performed for KDPI – KDRI and DGF for both groups. A p lower than 0.05 was considered significant. Results A total of 28 DBD KTx, 18 double (64.3%) and 10 single (35.7%) and 7 DCD KTx, 3 double (42.8%) and 4 single (57.2%) were observed during the study. Donors and recipients clinical and immunological characteristics are reported in table1. All of DCD and 64.3% of DBD donors underwent kidney biopsy (Karpinski values are reported in table 1). Induction therapy was with aTG in DCD KTx and ECD DBD KTx and with anti-interleukin-2 receptor monoclonal antibodies in SCD DBD KTx. Maintenance immunosuppression consisted in steroid, tacrolimus and mycophenolic acid. KTx outcomes were reported in table 1 with no differences in both groups between creatinine (p0.3) and eGFR (p0.25). We analyzed KDPI and KDRI values from DBD and DCD KTx and we stratified them as reported in table 2. We found 7 DGF in DBD KTx (85% with KDPI &gt;85% and KDRI &gt;1.5) and only 1 DGF in DCD KTx with KDPI&gt;85% and KDRI &gt; 1.5. We did not find a statistical correlation between KDPI- KDRI and eGFR in both DBD KTx (2 patients died and 3 patients were lost at follow up) (r -0.32, p 0.13; r -0.26, p 0.22) and DCD KTx (r -0.59, p 0.15; r -0.47, p 0.28). (Figure 1) We performed a ROC curve Analysis to investigate the role of KDPI – KDRI and the risk of DGF. We found no statistical correlation in DCD KTx, considering the small sample size (p 0.61) but we found a significant statistical value in DBD KTx (p 0.03 – p 0.02 with a AUC of 0.77-0.78). Survival analysis did not show statistical difference between DBD and DCD (p 0.72), no graft loss in the first year, although two DBD (92.8%) recipients died (1circulatory arrest,1 sepsis), no one died in DCD group. Conclusion cDCD is a valid resource for KTx, with similar outcomes to DBD. This remarks the importance of a multidisciplinary team and a correct selection of donors. We did not find a correlation between KDPI-KDRI and KTX function after one year of follow up in our population for either group.

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