scholarly journals Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study

2020 ◽  
Vol 61 (4) ◽  
pp. 537-545 ◽  
Author(s):  
Gemma Cadby ◽  
Phillip E. Melton ◽  
Nina S. McCarthy ◽  
Corey Giles ◽  
Natalie A. Mellett ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Correlation ◽  
Genetic Correlations ◽  
Whole Genome Sequencing Data ◽  
Sequencing Data ◽  
Cvd Risk ◽  
Family Heart Study ◽  
Heart Study ◽  
Lipid Species ◽  
Future Work

CVD is the leading cause of death worldwide, and genetic investigations into the human lipidome may provide insight into CVD risk. The aim of this study was to estimate the heritability of circulating lipid species and their genetic correlation with CVD traits. Targeted lipidomic profiling was performed on 4,492 participants from the Busselton Family Heart Study to quantify the major fatty acids of 596 lipid species from 33 classes. We estimated narrow-sense heritabilities of lipid species/classes and their genetic correlations with eight CVD traits: BMI, HDL-C, LDL-C, triglycerides, total cholesterol, waist-hip ratio, systolic blood pressure, and diastolic blood pressure. We report heritabilities and genetic correlations of new lipid species/subclasses, including acylcarnitine (AC), ubiquinone, sulfatide, and oxidized cholesteryl esters. Over 99% of lipid species were significantly heritable (h2: 0.06–0.50) and all lipid classes were significantly heritable (h2: 0.14–0.50). The monohexosylceramide and AC classes had the highest median heritabilities (h2 = 0.43). The largest genetic correlation was between clinical triglycerides and total diacylglycerol (rg = 0.88). We observed novel positive genetic correlations between clinical triglycerides and phosphatidylglycerol species (rg: 0.64–0.82), and HDL-C and alkenylphosphatidylcholine species (rg: 0.45–0.74). Overall, 51% of the 4,768 lipid species-CVD trait genetic correlations were statistically significant after correction for multiple comparisons. This is the largest lipidomic study to address the heritability of lipids and their genetic correlation with CVD traits. Future work includes identifying putative causal genetic variants for lipid species and CVD using genome-wide SNP and whole-genome sequencing data.

Abstract MP65: Masked Hypertension is Associated with Cardiovascular Disease Events in African Americans: The Jackson Heart Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
John N Booth ◽  
Keith M Diaz ◽  
Samantha Seals ◽  
Mario Sims ◽  
Joseph Ravenell ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
African Americans ◽  
Blood Pressure Monitoring ◽  
Masked Hypertension ◽  
Jackson Heart Study ◽  
Cvd Risk ◽  
Nocturnal Hypertension ◽  
Heart Study ◽  
All Cause Mortality

Introduction: Masked hypertension has been associated with increased cardiovascular disease (CVD) risk in Europeans and Asians. Hypothesis: Determine the association of masked hypertension with CVD events and all-cause mortality in African Americans (AA). Methods: The Jackson Heart Study, an exclusively AA population-based, prospective cohort study, was restricted to participants with clinic systolic/diastolic blood pressure (SBP/DBP) < 140/90 mmHg and valid ambulatory blood pressure monitoring (ABPM) at the baseline exam in 2000-2004 (n=738). Masked daytime hypertension was defined as mean ambulatory daytime (10am-8pm) SBP ≥ 135 mmHg or DBP ≥ 85 mmHg. Masked nocturnal hypertension was defined as mean ambulatory nighttime (12am-6am) SBP ≥ 120 mmHg or DBP ≥ 70 mmHg. Using all ABPM measurements, masked 24-hour hypertension was defined as mean SBP ≥ 130 mmHg or DBP ≥ 80 mmHg. CVD events (nonfatal/fatal stroke, nonfatal myocardial infarction or fatal coronary heart disease) and all-cause mortality were identified and adjudicated through December 31, 2011. Results: Any masked hypertension (masked daytime, nocturnal or 24-hour hypertension) was present in 52.2% of participants; 28.2% had masked daytime hypertension, 48.2% had masked nocturnal hypertension and 31.7% had masked 24-hour hypertension. There were 51 CVD events and 44 deaths over a median follow up of 8.2 and 8.5 years, respectively. The CVD rate (95% CI) per 1,000 person years in participants with and without any masked hypertension were 13.5 (9.9-18.4) and 3.9 (2.2-7.1), respectively (Table). The multivariable adjusted hazard ratio (95% CI) between any masked hypertension and CVD was 2.49 (1.26-4.93). CVD rates for those with and without masked daytime, nocturnal and 24-hour hypertension, and the hazard ratios for CVD associated with masked daytime, nocturnal and 24-hour hypertension, were similar. Masked hypertension was not associated with all-cause mortality. Conclusion: Masked hypertension is common and associated with increased CVD risk in AAs.

scholarly journals Blood Pressure Percentiles in 22,051 German Children and Adolescents: The PEP Family Heart Study

2014 ◽  
Vol 28 (5) ◽  
pp. 672-679 ◽  
Author(s):  
Peter Schwandt ◽  
Juergen E. Scholze ◽  
Thomas Bertsch ◽  
Evelyn Liepold ◽  
Gerda M. Haas
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Family Heart Study ◽  
Heart Study ◽  
German Children

scholarly journals Leptin Is Associated With Blood Pressure and Hypertension in Women From the National Heart, Lung, and Blood Institute Family Heart Study

Hypertension ◽  
2009 ◽  
Vol 53 (3) ◽  
pp. 473-479 ◽  
Author(s):  
Duanduan Ma ◽  
Mary F. Feitosa ◽  
Jemma B. Wilk ◽  
Jason M. Laramie ◽  
Kai Yu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Institute ◽  
Family Heart Study ◽  
National Heart ◽  
Heart Study ◽  
National Heart Lung

scholarly journals Heritability and the Genetic Correlation of Heart Rate Variability and Blood Pressure in >29 000 Families

Hypertension ◽  
2020 ◽  
Vol 76 (4) ◽  
pp. 1256-1262
Author(s):  
Balewgizie S. Tegegne ◽  
Tengfei Man ◽  
Arie M. van Roon ◽  
Nigus G. Asefa ◽  
Harriëtte Riese ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Genetic Correlation ◽  
Root Mean Square ◽  
Genome Wide Association Study ◽  
Genetic Correlations ◽  
Substantial Contribution ◽  
Mean Square ◽  
Cardiac Autonomic Nervous System

Dysregulation of the cardiac autonomic nervous system, as indexed by reduced heart rate variability (HRV), has been associated with the development of high blood pressure (BP). However, the underlying pathological mechanisms are not yet fully understood. This study aimed to estimate heritability of HRV and BP and to determine their genetic overlap. We used baseline data of the 3-generation Lifelines population-based cohort study (n=149 067; mean age, 44.5). In-house software was used to calculate root mean square of successive differences and SD of normal-to-normal intervals as indices of HRV based on 10-second resting ECGs. BP was recorded with an automatic BP monitor. We estimated heritabilities and genetic correlations with variance components methods in ASReml software. We additionally estimated genetic correlations with bivariate linkage disequilibrium score regression using publicly available genome-wide association study data. The heritability (SE) estimates were 15.6% (0.90%) for SD of normal-to-normal intervals and 17.9% (0.90%) for root mean square of successive differences. For BP measures, they ranged from 24.4% (0.90%) for pulse pressure to 30.3% (0.90%) for diastolic BP. Significant negative genetic correlations (all P <0.0001) of root mean square of successive differences/SD of normal-to-normal intervals with systolic BP (−0.20/−0.16) and with diastolic BP (−0.15/−0.13) were observed. LD score regression showed largely consistent genetic correlation estimates of root mean square of successive differences/SD of normal-to-normal intervals with systolic BP (range, −0.08 to −0.23) and diastolic BP (range, −0.20 to −0.27). Our study shows a substantial contribution of genetic factors in explaining the variance of HRV and BP measures in the general population. The significant negative genetic correlations between HRV and BP indicate that genetic pathways for HRV and BP partially overlap.

Abstract P337: Lifetime Burden of Traditional Cardiovascular Disease Risk Factors and Incidence of Cancer: The Bogalusa Heart Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Alexander C Razavi ◽  
Tanika N Kelly ◽  
Jiang He ◽  
Camilo Fernandez ◽  
Tekada Ferguson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cancer Risk ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Bogalusa Heart Study ◽  
Incidence Of Cancer ◽  
Incident Cancer ◽  
Heart Study

Introduction: Cardiovascular disease (CVD) and cancer remain the leading causes of death globally. While these diseases have traditionally been regarded as separate entities, recent evidence points towards shared biological pathways, underlying a need to study CVD and cancer conjointly. We examined the association between CVD risk factors and the incidence of cancer over the life course in a biracial community-based cohort. Methods: The analysis included 1,368 participants of the Bogalusa Heart Study who had at least 3 measurements of CVD risk factors throughout life (57.6% women, 32.8% black, baseline age=10.5 + 3.6 years, median follow-up=38.2 years). CVD risk factors assessed included systolic and diastolic blood pressure, LDL-C, HDL-C, plasma glucose, serum triglycerides, and body mass index (BMI). Cancer cases were ascertained via the Louisiana Tumor Registry. Cox proportional hazards regression assessed the association between CVD risk factors and cancer incidence, adjusting for race, sex, smoking, and blood pressure-, lipid-, and glucose-lowering medications. Results: There were 88 incident cases of cancer, with breast (22.7%), cervical (11.4%), and prostate (9.1%) being the most highly represented cancers. BMI (kg/m 2 ) had the most robust association with incident cancer (HR=5.83, 95% CI: 2.24, 15.19; p=3.0x10 -4 ). We observed a strong association between annualized change in blood pressure per mmHg and hazard of all cancers (for systolic, HR=2.24, 95% CI: 1.50, 3.35; p<0.0001 and diastolic, HR=4.86, 95% CI: 2.86, 8.27; p<0.0001). Race and sex significantly modified the relationship of incident cancer with lipids and blood pressure, respectively ( Figure ). Conclusion: Subclinical increases in adiposity and blood pressure associate with an increased cancer risk, while HDL-C inversely associates with cancer risk, more consistently in women versus men and in blacks versus whites. Control of CVD risk factors beginning in childhood may lead to improved overall cancer prevention in the general population.

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