The In Vitro Effect of Estradiol and Testosterone on Iron-Induced Lipid Peroxidation in Rat Brain and Kidney Tissues

2005 ◽  
Vol 1053 (1) ◽  
pp. 400-404 ◽  
Author(s):  
P. J. REQUINTINA
Keyword(s):  
Lipid Peroxidation ◽  
Rat Brain ◽  
Vitro Effect

Kainate-induced lipid peroxidation in rat brain in vitro is markedly reduced by the endogenous antioxidant melatonin

1995 ◽  
Vol 31 ◽  
pp. 295
Author(s):  
Daniela Melchiorri ◽  
Russel J. Reiter ◽  
Ewa Sewerynek ◽  
Li Dun Chen ◽  
Giuseppe Nisticò
Keyword(s):  
Lipid Peroxidation ◽  
Rat Brain ◽  
Endogenous Antioxidant

The in vitro effect of Helichrysi flos on microsomal lipid peroxidation

2001 ◽  
Vol 77 (1) ◽  
pp. 31-35 ◽  
Author(s):  
E. Czinner ◽  
K. Hagymási ◽  
A. Blázovics ◽  
Á. Kéry ◽  
É. Szőke ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Microsomal Lipid Peroxidation ◽  
Vitro Effect

In Vitro Effect of Lead on Na+, K+-ATPase Activity in Different Regions of Adult Rat Brain

2003 ◽  
Vol 26 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Prabhakara Rao Yallapragada ◽  
Jennifer Butler ◽  
Bokara Kiran Kumar ◽  
Bettaiya Rajanna
Keyword(s):  
Atpase Activity ◽  
Rat Brain ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Vitro Effect

scholarly journals Antioxidative Activity of Ferrocenes Bearing 2,6-Di-Tert-Butylphenol Moieties

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
E. R. Milaeva ◽  
S. I. Filimonova ◽  
N. N. Meleshonkova ◽  
L. G. Dubova ◽  
E. F. Shevtsova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Brain ◽  
Antioxidative Activity ◽  
Neuroprotective Effect ◽  
In Vitro Study ◽  
Brain Homogenate ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Calcium Dependent

The antioxidative activity of ferrocenes bearing either 2,6-di-tert-butylphenol or phenyl groups has been compared using DPPH (1,1-diphenyl-2-picrylhydrazyl) test and in the study of the in vitro impact on lipid peroxidation in rat brain homogenate and on some characteristics of rat liver mitochondria. The results of DPPH test at20∘C show that the activity depends strongly upon the presence of phenolic group but is improved by the influence of ferrocenyl fragment. The activity of N-(3,5-di-tert-butyl-4-hydroxyphenyl)iminomethylferrocene (1), for instance, was 88.4%, which was higher than the activity of a known antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT) (48.5%), whereas the activity of N-phenyl-iminomethylferrocene2was almost negligible−2.9%. The data obtained demonstrate that the compounds with 2,6-di-tert-butylphenol moiety are significantly more active than the corresponding phenyl analogues in the in vitro study of lipid peroxidation in rat brain homogenate. Ferrocene1performs a promising behavior as an antioxidant and inhibits the calcium-dependent swelling of mitochondria. These results allow us to propose the potential cytoprotective (neuroprotective) effect of ditopic compounds containing antioxidant 2,6-di-tert-butylphenol group and redox active ferrocene fragment.

The in vitro effect of l-prolyl-l-leucyl-glycineamide (MIF-1) on the guanylate cyclase system of a crude rat brain mitochondrial fraction

Neuropeptides ◽  
1981 ◽  
Vol 1 (5) ◽  
pp. 391-400 ◽  
Author(s):  
A.R. Gerber ◽  
K.S. Wood ◽  
A.O. Sartor ◽  
W.F. Wheeler ◽  
T.C. Gayle ◽  
...  
Keyword(s):  
Rat Brain ◽  
Guanylate Cyclase ◽  
Mitochondrial Fraction ◽  
Vitro Effect

scholarly journals Brain Lipid Peroxidation Induced by Postischemic Reoxygenation in vitro: Effect of Vitamin E

1984 ◽  
Vol 4 (3) ◽  
pp. 466-469 ◽  
Author(s):  
Shinichi Yoshida ◽  
Raul Busto ◽  
Mercedes Santiso ◽  
Myron D. Ginsberg
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Lipid Peroxides ◽  
Aerobic Incubation ◽  
Ischemic Hypoxia ◽  
Brain Lipid Peroxidation ◽  
Vitro Effect ◽  
The Brain ◽  
Slow Propagation

The aerobic incubation of brain afer a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E—deficient rats, intermediate in vitamin E—normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E—deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.

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