The Role of Clinical Factors, Wood's Lamp Examination, and Slit Lamp Examination in the Diagnosis of Eye Disease in the ED

Myopia the commonest refractive error includes a large section of present day population. myopia along with other refractive errors accounts for 7 % of the causes of blindness in India. It is highly significant problem. Myopia is dioptric condition of the eye in which incident parallel rays come to a focus anterior to the light sensitive part of the Retina. When accommodation is at rest. Myopia is the commonest eye defect affecting the young eyes and also called near or short sightedness[1]. Clinical factors related to vision disturbance are seeing in Drishtigatrogas and one among these roga is Timira . Blurred Vision is mentioned as symptom in 12 Drishtigat Vikaras. Timira is such an eye disease which starts from Avyaktya darshana and end in complete loss of vision. No separate etiological factors at the eye are to be considered for Timira . Acharya Sushruta has described Timira as Ghora roga . that produce visual disturbance due to accumulation of doshas in various patalas of the eye[2]. Due to changing life style and excessive use of computer, TV, mobile screen worsen visual acuity and produce various Netra Rogas and people use mostly modern medicine, but in Ayurveda with the help many therapies like padabhyanga . Padabhyanga is good for eye. Vagabhata identities 4 major nerves in the feet that connect to the eyes. These transmit the effect of the medicine applied over the feet in the form of massage [3] . Hence every person should need make use of padabhyanga . Major causes of blindness, for prevalence disease like Timira . Hence the study is made to explain effect of padábhyanga to increase and maintain the visual acuity.

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Late-onset malignant glaucoma

Latin American Journal of Ophthalmology ◽

10.25259/lajo_19_2019 ◽

2020 ◽

Vol 3 ◽

pp. 1

Author(s):

Ramiro José Daud ◽

Horacio Freile ◽

Mauricio Freile ◽

Soledad Mariano

Keyword(s):

Intraocular Pressure ◽

Case Report ◽

Acute Pain ◽

Late Onset ◽

Slit Lamp ◽

Normal Range ◽

Slit Lamp Examination ◽

Complete Occlusion ◽

Malignant Glaucoma ◽

The Right

A case report on a 49-year-old female with diagnoses of ocular hypertension in her left eye (LE) treated with 250 mg/day acetazolamide for 2 years. During the slit-lamp examination, complete occlusion of both iridocorneal angles was detected. Intraocular pressure (IOP) was 10 and 35 mmHg in the right eye and LE, respectively. Phacotrabeculectomy was performed in the LE. After 1 month of the procedure, the patient developed a slowly progressive miopization from −1 to −3 diopters (D) the following months. Approximately 3 months after surgery, the patient developed an episode of acute pain, athalamia, and IOP 45 mmHg in her LE. Late-onset malignant glaucoma was suspected and the patient was treated with topical hypotensive and cycloplegic agent until a prompt vitrectomy was performed. Deepening of the anterior chamber and restoration of IOP to normal range was obtained after surgery.

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The Level of Cytokines in the Vitreous Body of Severe Proliferative Diabetic Retinopathy Patients Undergoing Posterior Vitrectomy

Current Pharmaceutical Design ◽

10.2174/1381612824666180926110704 ◽

2018 ◽

Vol 24 (27) ◽

pp. 3276-3281 ◽

Cited By ~ 3

Author(s):

Dorota Raczyńska ◽

Katarzyna A. Lisowska ◽

Krzysztof Pietruczuk ◽

Joanna Borucka ◽

Mateusz Ślizień ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Proliferative Diabetic Retinopathy ◽

Vitreous Body ◽

Control Group ◽

Slit Lamp ◽

Corrected Visual Acuity ◽

Cytokine Levels ◽

Pars Plana ◽

Eye Examination

Objective: The objective of the study was to compare cytokine levels in the vitreous body of patients with proliferative diabetic retinopathy (PDR) undergoing posterior vitrectomy. Patients and methods: The study included 39 patients (39 eyes) undergoing pars plana vitrectomy (PPV). Patients were divided into three groups: patients with proliferative diabetic retinopathy (PDR) without aflibercept injection prior to the surgery, PDR patients administered aflibercept injection prior to the surgery, and patients without diabetes mellitus (control group). All patients underwent a comprehensive eye examination one day before and 3 weeks after the surgery, including measurements of: best-corrected visual acuity (BVCA) and intraocular pressure (IOP), slit-lamp examination and spectral domain optical coherence tomography (SOCT). Concentrations of cytokines: IL-6, IL-8, IL-12p70, TNF, IL-10, IL-1β were measured in the vitreous body of patients with BD™ Cytometric Bead Array (CBA) Human Inflammatory Cytokines Kit. Results: PDR patients who received pretreatment with aflibercept injection showed significantly lower concentrations of IL-12p70, TNF, IL-10 and IL-1β in the vitreous body compared to the control group. Meanwhile, patients without prior aflibercept injection had a significantly higher concentration of IL-8. There was also a significant positive correlation between IOP before PPV and IL-8 concentration in both PDR patients’ groups. Conclusion: Findings of our study suggest an important role of IL-8 in the development of severe PDR. Aflibercept administration on the day before elective vitrectomy facilitated the surgery.

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Identification of a Novel Missense KRT12 Mutation in a Vietnamese Family with Meesmann Corneal Dystrophy

Case Reports in Ophthalmology ◽

10.1159/000506435 ◽

2020 ◽

Vol 11 (1) ◽

pp. 120-126

Author(s):

Pham Ngoc Dong ◽

Le Xuan Cung ◽

Tran Khanh Sam ◽

Do Thi Thuy Hang ◽

Doug D. Chung ◽

...

Keyword(s):

Sanger Sequencing ◽

Novel Mutation ◽

Family Members ◽

Corneal Dystrophy ◽

Slit Lamp ◽

Slit Lamp Examination ◽

Corneal Epithelial ◽

Epithelial Phenotype ◽

History Of ◽

Characteristic Features

Meesmann epithelial corneal dystrophy (MECD) is a rare dominantly inherited disorder that is characterized by corneal epithelial microcysts and is associated with mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes. In this study, we report a novel mutation in the KRT12 gene in a Vietnamese pedigree with MECD. Slit-lamp examination was performed on each of the 7 recruited members of a Vietnamese family to identify characteristic features of MECD. After informed consent was obtained from each individual, genomic DNA was isolated from saliva samples and screening of KRT3and KRT12 genes was performed by Sanger sequencing. The proband, a 31-year-old man, complained of a 1-year history of eye irritation and photophobia. Slit-lamp examination revealed intraepithelial microcysts involving only the corneal periphery in each eye with clear central corneas and no stromal or endothelial involvement. Three family members demonstrated similar intraepithelial microcysts, but with diffuse involvement, extended from limbus to limbus. Sanger sequencing of KRT3 (exon 7) and KRT12 (exons 1 and 6) in the proband revealed a novel heterozygous KRT12 variant (c.1273G>A [p.Glu425Lys]) that was present in the three affected family members but was absent in the three family members with clear corneas. This study is the first report of a Vietnamese family affected with MECD, associated with an atypical peripheral corneal epithelial phenotype in the proband and a novel mutation in KRT12.

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Pathological Role of Apelin in Angiogenic Eye Disease

YAKUGAKU ZASSHI ◽

10.1248/yakushi.131.1201 ◽

2011 ◽

Vol 131 (8) ◽

pp. 1201-1206 ◽

Cited By ~ 2

Author(s):

Atsushi KASAI

Keyword(s):

Eye Disease

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Severe Corneal Morphological Alterations after Excimer Laser Surface Ablation for a High Astigmatism

Case Reports in Ophthalmology ◽

10.1159/000516311 ◽

2021 ◽

pp. 492-496

Author(s):

Anna M. Roszkowska ◽

Giovanni W. Oliverio ◽

Giuseppe A. Signorino ◽

Mario Urso ◽

Pasquale Aragona

Keyword(s):

Excimer Laser ◽

Corneal Stroma ◽

Corneal Topography ◽

Laser Surface ◽

Slit Lamp ◽

Slit Lamp Examination ◽

Morphological Alterations ◽

Surface Ablation ◽

Confocal Images

We report long-term alterations of anterior corneal stroma after excimer laser surface ablation for a high astigmatism. The patient claimed progressive visual loss in his right eye (RE) during the last 3 years after bilateral laser-assisted subepithelial keratectomy (LASEK) surgery. His examination comprised visual acuity (UDVA and CDVA), slit-lamp examination, corneal topography and tomography, AS-OCT, and confocal microscopy. The UDVA was 0.1 in his RE and 1.0 in the left eye. The CDVA in the RE was 0.8. The slit-lamp examination showed a stromal lesion in the inferior paracentral corneal zone, with multiple vertical tissue bridges and severe thinning. Corneal topography and tomography showed central flattening with inferior steepening and severe alteration in elevation maps. AS-OCT showed void areas in the anterior stroma with thinning of the underlying tissue, and confocal images were not specific. In this case, progressive corneal steepening and thinning that manifest topographically as inferior ectasia occurred in correspondence to the singular stromal alterations after LASEK.

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Progressive multifocal leukoencephalopathy in a patient with occult hypogammaglobulinemia experiencing bilateral visual impairment

European Journal of Ophthalmology ◽

10.1177/1120672121990535 ◽

2021 ◽

pp. 112067212199053

Author(s):

Sameera Hettipathirannahelage ◽

Sidath Wijetilleka ◽

Hugh Jewsbury

Keyword(s):

Progressive Multifocal Leukoencephalopathy ◽

Visual Impairment ◽

Demyelinating Disease ◽

Parietal Lobe ◽

Previous History ◽

White Matter Lesions ◽

Slit Lamp ◽

Slit Lamp Examination ◽

History Of ◽

Ishihara Test

Introduction: Progressive multifocal leukoencephalopathy (PML) is a rare, lethal, demyelinating disease classically seen in profoundly immunosuppressed individuals. It is caused by intracerebral infection by John Cunningham polyomavirus (JCV). We report a rare case of PML in a man with presumed immunocompetence at presentation experiencing bilateral painless visual impairment. Case Description: A 60-year-old man with a 3-week history of bilateral painless visual impairment attended our ophthalmology department. Unusually, he navigated around the room well and was able to read 4 of 13 Ishihara test plates in spite of a best-corrected visual acuity of counting fingers at 1 m bilaterally. Slit lamp examination, routine blood tests and optical coherence tomography (OCT) of the maculae and discs were unremarkable. Diffuse hyperintense white matter lesions on T2-weighted magnetic resonance imaging of the brain and detection of JCV within the parietal lobe tissue obtained by biopsy confirmed PML. Additional investigations identified an underlying hypogammaglobulinaemia, which may have initiated PML. He received intravenous immunoglobulin but passed away 2 months after diagnosis. Conclusions: To our knowledge this case is one of only a handful worldwide to describe PML developing in a patient with presumed immunocompetence at presentation – there was no previous history of recurrent, chronic, or atypical infections. There has only been one other report of visual symptoms presenting as the primary complaint. The case illustrates the importance of ruling out organic, central nervous system pathology in patients presenting with visual loss and normal objective visual function tests such as slit lamp examination and OCT.

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