Clinicopathologic correlations of cutaneous neuroendocrine Merkel cell carcinoma.

1988 ◽  
Vol 6 (12) ◽  
pp. 1863-1873 ◽  
Author(s):  
S Pilotti ◽  
F Rilke ◽  
C Bartoli ◽  
A Grisotti

A study of 50 consecutive cases (22 men, 28 women; age range, 39 to 84 years; mean age, 65 years) of cutaneous neuroendocrine Merkel cell carcinoma (CNC), 39 of whom had a mean follow-up of 34 months, revealed that the prognostic significance of the histopathologic subtyping in trabecular, solid, and diffuse variants of CNC was not as important as the pathologic postsurgical staging in localized, regional, and extraregional disease. The overall mortality was 23.5%. None of the 19 patients with localized disease died of CNC, while 11% of the 24 patients with regional disease and all seven patients with extraregional disease at presentation died of CNC. A second primary malignancy was found to be associated with the CNC in 15% of the cases. The clinical course in patients with localized disease was favorable in spite of the high number of local recurrences. Also, the presence of regional metastases was not related to an unfavorable prognosis. In 68% of the cases the disease involved the lower limbs or girdle. In ten cases the overt exophytic presentation of primary CNC was replaced by the presence of tumor masses infiltrating the inguinal soft tissues with or without nodal involvement.

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Loren Masterson ◽  
Bryan J. Thibodeau ◽  
Laura E. Fortier ◽  
Timothy J. Geddes ◽  
Barbara L. Pruetz ◽  
...  

Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study. Patients were stratified into good, moderate, or poor prognosis. Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors. In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, andKITwere upregulated in specimens from patients with poor prognosis. Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients.


2019 ◽  
Vol 43 (7) ◽  
pp. 907-919 ◽  
Author(s):  
Emily M. Erstine ◽  
Michael T. Tetzlaff ◽  
Xuefei Jia ◽  
Phyu P. Aung ◽  
Victor G. Prieto ◽  
...  

2010 ◽  
Vol 14 (2) ◽  
pp. 51-61 ◽  
Author(s):  
Anna Zampetti ◽  
Claudio Feliciani ◽  
Guido Massi ◽  
Antonello Tulli

Background:Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor of the elderly or immunosuppressed individuals that usually appears on sun-exposed areas of the body. Its pathogenesis is still debated, and, currently, no standardized treatment exists.Objective:To provide a current updated review of the most relevant data concerning the pathogenesis and management of Merkel cell carcinoma.Methods:Using relevant MeSH terms, we performed a review of the literature on these subjects from 1980 to June 2009.Results and Conclusion:The current management of Merkel cell carcinoma is based on surgical excision as the majority of patients present with localized disease, whereas up to 30% have regional lymph node metastases. In these cases, the best outcome is achieved with multidisciplinary management that includes radiotherapy. Chemotherapy is part of the treatment in advanced cases and is mandatory for distant metastatis. Given that a recent work showed the presence of a previously unknown polyomavirus, which the authors called Merkel cell polyomavirus, the therapeutical approach to Merkel cell carcinoma could be reconsidered in the future.


2002 ◽  
Vol 28 (2) ◽  
pp. 113-117
Author(s):  
KHOSROW MEHRANY ◽  
CLARK C. OTLEY ◽  
ROGER H. WEENIG ◽  
P. KIM PHILLIPS ◽  
RANDALL K. ROENIGK ◽  
...  

2013 ◽  
Vol 17 (5) ◽  
pp. 351-355 ◽  
Author(s):  
Andrea Marchesi ◽  
Pier Camillo Parodi ◽  
Marco Brioschi ◽  
Giorgio Sileo ◽  
Matteo Marchesi ◽  
...  

Background:Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy that usually grows rapidly at the head and neck. Giant forms at the lower limbs are rarely reported and usually affect patients in the eighth decade or older.Methods:We report the case of a 60-year-old man who presented with a giant MCC on his right thigh. We managed this case by applying the 2012 updated guidelines and reviewed all cases of giant MCC of the lower limbs reported in the literature.Results:At the 4-month follow-up, the patient showed complete remission.Conclusion:Giant forms of MCC are still treated as typical cases of MCC, when these patients show a very poor prognosis. In young and adult people, such as our case, wide surgical excisions, sentinel lymph node biopsy in clinically negative node cases, radiotherapy of the regional drain area, and a strict follow-up should be routinely performed to improve patients' survival.


2016 ◽  
Vol 5 (2) ◽  
pp. 205-212
Author(s):  
Michael A. Fu ◽  
Evan C. Osmundson ◽  
Rie von Eyben ◽  
Susan J. Knox ◽  
Daniel S. Kapp

2020 ◽  
Vol 129 (1) ◽  
pp. e45-e46
Author(s):  
FERNANDO SILVA DE CASTRO ◽  
MÔNICA SIMÕES ISRAEL ◽  
ROSEMIRO MENEZES MACIEL ◽  
SARAH APARECIDA FERREIRA ANTERO ◽  
WAGNER PINTO DAS CHAGAS ◽  
...  

2014 ◽  
Vol 272 (7) ◽  
pp. 1777-1783 ◽  
Author(s):  
Alexandra Fochtmann ◽  
Georg Haymerle ◽  
Rainer Kunstfeld ◽  
Johannes Pammer ◽  
Matthaeus Ch. Grasl ◽  
...  

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