Gene expression analysis of head and neck squamous cell carcinoma using formalin-fixed paraffin embedded tissue

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 5537-5537
Author(s):  
C. H. Chung ◽  
J. Carter ◽  
K. Ely ◽  
B. A. Murphy ◽  
B. B. Burkey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Expression Analysis ◽  
Squamous Cell ◽  
Gene Expression Analysis ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed

scholarly journals Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence

Oncotarget ◽  
2014 ◽  
Vol 6 (1) ◽  
pp. 547-555 ◽  
Author(s):  
Xu Zhi ◽  
Katarzyna Lamperska ◽  
Paweł Golusinski ◽  
Nicholas J. Schork ◽  
Lukasz Luczewski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Expression Analysis ◽  
Squamous Cell ◽  
Gene Expression Analysis ◽  
Neck Squamous Cell Carcinoma

scholarly journals Genomic Landscape of Head and Neck Squamous Cell Carcinoma Across Different Anatomic Sites in Chinese Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Yunhe Ju ◽  
Xingrao Wu ◽  
Huizhen Wang ◽  
Bin Li ◽  
Qing Long ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Chinese Population ◽  
Neck Squamous Cell Carcinoma ◽  
Targeted Sequencing ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed

BackgroundThe characteristics of head and neck squamous cell carcinoma (HNSCC) across different anatomic sites in the Chinese population have not been studied. To determine the genomic abnormalities underlying HNSCC across different anatomic sites, the alterations of selected cancer-related genes were evaluated.MethodsGenomic DNA samples obtained from formalin-fixed, paraffin-embedded tissues were analyzed using targeted sequencing in a panel of 383 cancer-related genes to determine the genomic alterations.ResultsA total of 317 formalin-fixed, paraffin-embedded HNSCC specimens were collected, and a total of 2,156 protein-coding mutations, including 1,864 single nucleotide variants and 292 insertions and deletions, were identified across more than six different anatomic sites. Mutation loads were distinct across the anatomic sites. Larynx carcinoma was found with the highest mutation loads, whereas nasopharynx carcinoma showed the lowest mutation loads. A total of 1,110 gains and 775 losses were identified in the 317 specimens. Patients who had at least one clinically actionable alteration (levels 1–4 in OncoKB) were identified. One patient had an actionable alteration with level 1 evidence in OncoKB, TEX10-NTRK2 fusion, who may benefit from larotrectinib or entrectinib treatment.ConclusionThe genomic profiling of HNSCC using targeted sequencing can identify rational therapeutic candidate genes suitable for the treatment of the HNSCCs.

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