Cancer treatment side effects in breast cancer patients receiving radiation therapy

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 705-705 ◽  
Author(s):  
M. Hofman ◽  
J. T. Hickok ◽  
G. R. Morrow ◽  
J. A. Roscoe ◽  
L. J. Gillies ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Treatment Side Effects

scholarly journals COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area

2020 ◽  
Author(s):  
Perrine Vuagnat ◽  
Maxime Frelaut ◽  
Toulsie Ramtohul ◽  
Clémence Basse ◽  
Sarah Diakite ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Intensive Care Unit ◽  
Radiation Therapy ◽  
Intensive Care ◽  
Metastatic Breast Cancer ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Paris Area

AbstractBackgroundCancer patients have been reported to be at higher risk of COVID-19 complications and deaths. We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France).MethodsAn IRB-approved prospective registry was set up at ICH for all breast cancer patients with COVID-19 symptoms or radiologic signs.ResultsAmong 15,600 patients actively treated for early or metastatic breast cancer during the last 4 months at ICH, 76 patients with suspected COVID-19 infection were included in the registry and followed. Fifty-nine of these patients were diagnosed with COVID-19 based on viral RNA testing or typical radiologic signs: 37/59 (63%) COVID-19 patients were treated for metastatic breast cancer, and 13/59 (22%) of them were taking corticosteroids daily. Common clinical features mostly consisted of fever and/or cough, while ground-glass opacities were the most common radiologic sign at diagnosis. We found no association between prior radiation therapy fields or extent of radiation therapy sequelae and extent of COVID-19 lung lesions. Twenty-eight of these 59 patients (47%) were hospitalized and 6 (10%) were transferred to an intensive care unit. At the time of analysis, 45/59 (76%) patients were recovering or had been cured, 10/59 (17%) were still followed and 4/59 (7%) had died from COVID-19. All 4 patients who died had significant non-cancer comorbidities. In univariate analysis, hypertension and age (>70) were the two factors associated with a higher risk of intensive care unit admission and/or death.ConclusionsThis prospective registry analysis suggests that the COVID-19 mortality rate in breast cancer patients depends more on comorbidities than prior radiation therapy or current anti-cancer treatment. Special attention must be paid to comorbidities when estimating the risk of severe SARS-CoV-2 infection in breast cancer patients.

scholarly journals Geographic access to radiation therapy facilities and disparities of early-stage breast cancer treatment

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Yan Lin ◽  
Michael C. Wimberly ◽  
Patricia Da Rosa ◽  
Joseph Hoover ◽  
William F. Athas
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Treatment ◽  
South Dakota ◽  
Cancer Patients ◽  
Early Stage ◽  
Breast Cancer Treatment ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Patients ◽  
To Receive

Few studies of breast cancer treatment have focused on the Northern Plains of the United States, an area with a high mastectomy rate. This study examined the association between geographic access to radiation therapy facilities and receipt of breast cancer treatments among early-stage breast cancer patients in South Dakota. Based on 4,209 early-stage breast cancer patients diagnosed between 2001 and 2012 in South Dakota, the study measured geographic proximity to radiation therapy facilities using the shortest travel time for patients to the closest radiation therapy facility. Two-level logistic regression models were used to estimate for early stage cases i) the odds of mastectomy versus breast conserving surgery (BCS); ii) the odds of not receiving radiation therapy after BCS versus receiving follow-up radiation therapy. Covariates included race/ethnicity, age at diagnosis, tumour grade, tumour sequence, year of diagnosis, census tract-level poverty rate and urban/rural residence. The spatial scan statistic method was used to identify geographic areas with significantly higher likelihood of experiencing mastectomy. The study found that geographic accessibility to radiation therapy facilities was negatively associated with the likelihood of receiving mastectomy after adjustment for other covariates, but not associated with radiation therapy use among patients receiving BCS. Compared with patients travelling less than 30 minutes to a radiation therapy facility, patients travelling more than 90 minutes were about 1.5 times more likely to receive mastectomy (odds ratio, 1.51; 95% confidence interval, 1.08-2.11) and patients travelling more than 120 minutes were 1.7 times more likely to receive mastectomy (odds ratio, 1.70; 95% confidence interval, 1.19-2.42). The study also identified a statistically significant cluster of patients receiving mastectomy who were located in south-eastern South Dakota, after adjustment for other factors. Because geographic proximity to treatment facilities plays an important role on the treatment for early-stage breast cancer patients, this study has important implications for developing targeted intervention to reduce disparities in breast cancer treatment in South Dakota.

Early Detection of Cardiotoxicity from Systemic and Radiation Therapy in Breast Cancer Patients (CardioTox Breast): Protocol Design of a Multi-Institutional Prospective Study (Preprint)

2021 ◽  
Author(s):  
Giulia Borgonovo ◽  
Elen Vettus ◽  
Alessandra Greco ◽  
Laura Anna Leo ◽  
Francesco Faletra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Magnetic Resonance ◽  
Early Detection ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Systemic Therapy ◽  
Study Endpoint ◽  
Breast Cancer Patients ◽  
Circulating Biomarkers

BACKGROUND Incidence of breast cancer is rising worldwide. Recent advances in systemic and local treatments have significantly improved survival rates of early breast cancer patients. In the last decade, great attention has been paid to prevention and early detection of cardiotoxicity induced by breast cancer treatments. Systemic therapy-related cardiac toxicities have been extensively studied. Radiotherapy, an essential component of breast cancer treatment, can also increase the risk of heart diseases. Consequently, it is important to balance the expected benefits of cancer treatment with cardiovascular risk and to identify strategies to prevent cardiotoxicity and improve long-term outcomes and quality of life for these patients. OBJECTIVE The Cardiotox study aims to investigate the use of cardiac magnetic resonance imaging and identify associated circulating biomarkers to assess early tissue changes in chemo- and radiation-induced cardiotoxicity in the time window of 12 months after the end of radiotherapy in breast cancer patients. METHODS The Cardiotox Breast trial is a multicenter, observational prospective longitudinal study. The aim is to identify any change in circulating biomarkers and cardiac imaging (based on cardiovascular magnetic resonance and echocardiography), to predict the incidence of cardiotoxicity and to detect it when is still subclinical and reversible. We plan to enrol 150 women with stage I-III, unilateral, breast cancer treated with breast conserving surgery and planned to receive radiotherapy with or without systemic therapy. RESULTS This study details the protocol of the CardioTox Breast trial. As of September 2020, thirteen patients have been enrolled by the Oncology Institute of Southern Switzerland and 4 patients by Fondazione IRCCS Policlinico San Matteo, Italy. Results of the present study will not be published until data are mature for the final analysis of the primary study endpoint. CONCLUSIONS The CardioTox Breast study is designed to investigate the effects of systemic and radiation therapy on myocardial function and structure, thus providing additional evidence on whether CMR is the optimal screening imaging for cardiotoxicity. CLINICALTRIAL ClinicalTrials.gov Identifier: NCT04790266

scholarly journals A review on the relationship between anti-mullerian hormone and fertility in treating young breast cancer patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yixuan Song ◽  
Hong Liu
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Young Patients ◽  
Breast Cancer Treatment ◽  
Breast Cancer Patients ◽  
Term Survival ◽  
Young Breast Cancer ◽  
The Relationship

AbstractDespite the fact that the long-term survival rate of breast cancer patients had been significantly improved owing to the systemic breast cancer therapies, there are still some side effects such as amenorrhea and fertility retention to be resolved, leaving it an important thing to understand the possible side effects on fertility and fertility preservation strategies while undergoing breast cancer treatment, due to the fact that most young patients hope to become pregnant and have children after breast cancer treatment. With anti-müllerian hormone (AMH) being the most sensitive marker for predicting ovarian function in young premenopausal women with breast cancer, this review is aimed to provide the additional guidance for clinical application of AMH by exploring the impacts of AMH on the fertility of young breast cancer patients, the relationship between AMH and metabolism, and the relationship between BRAC gene mutation and fertility protection strategies.

scholarly journals Radiation-induced side effects in breast cancer patients and factors affecting them

2020 ◽  
Vol 6 (2) ◽  
pp. 138-148 ◽  
Author(s):  
Afrin Sultana Chowdhury ◽  
Saheda Tamanna
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Side Effects ◽  
Cancer Patients ◽  
Inflammatory Responses ◽  
Receive Radiation Therapy ◽  
Breast Cancer Patients ◽  
Factors Affecting ◽  
Malignant Breast ◽  
Radiation Induced

Breast cancer is the most frequent malignancy and the leading cause of cancer morbidity and mortality in women worldwide. Radiation therapy (RT) is a widely used approach for its treatment. About 50% of patients with malignant breast tumors receive radiation therapy and most of them appear to tolerate it, but some experience severe side effects induced by this therapy. This variability of response may be caused by several factors, like age, inflammatory responses, body weight and variation in genes involved in the response to radiation-induced DNA damage. To limit radiotherapy side effects in breast cancer patients it is therefore important to have a good knowledge of these associated factors. This review discussed about the radiotherapy-related side effects in breast cancer patients and the factors affecting them. Asian J. Med. Biol. Res. June 2020, 6(2): 138-148

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

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