Quality of Life After Pelvic Radiotherapy or Vaginal Brachytherapy for Endometrial Cancer: First Results of the Randomized PORTEC-2 Trial

2009 ◽  
Vol 27 (21) ◽  
pp. 3547-3556 ◽  
Author(s):  
Remi A. Nout ◽  
Hein Putter ◽  
Ina M. Jürgenliemk-Schulz ◽  
Jan J. Jobsen ◽  
Ludy C.H.W. Lutgens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Endometrial Cancer ◽  
Social Functioning ◽  
Daily Activities ◽  
Life Questionnaire ◽  
Pelvic Radiotherapy ◽  
Bowel Symptoms ◽  
Cancer Module ◽  
Surgery Patient

PurposeStudies on quality of life (QOL) among women with endometrial cancer have shown that patients who undergo pelvic radiotherapy report lower role functioning and more diarrhea and fatigue. In the Post Operative Radiation Therapy in Endometrial Cancer (PORTEC) trial, patients with endometrial carcinoma were randomly assigned to receive external-beam radiotherapy (EBRT) or vaginal brachytherapy (VBT). QOL was evaluated by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and subscales from the prostate cancer module, PR-25, and the ovarian cancer module, OV-28.Patients and MethodsPORTEC-2 accrued 427 patients between 2002 and 2006, of whom 214 were randomly assigned to EBRT, and 213 were randomly assigned to VBT. Three-hundred forty-eight patients (81%) were evaluable for QOL. QOL outcomes were analyzed at a median follow-up of 2 years.ResultsAt baseline after surgery, patient functioning was at the lowest level, and it increased during and after radiotherapy to reach a plateau after 12 months. Patients in the VBT group reported better social functioning (P < .002) and lower symptom scores for diarrhea, fecal leakage, the need to stay close to the toilet, and limitation in daily activities because of bowel symptoms (P < .001). At baseline, 15% of patients were sexually active; this increased significantly to 39% during the first year (P < .001). Sexual functioning and symptoms did not differ between the treatment groups.ConclusionPatients who received EBRT reported significantly higher levels of diarrhea and bowel symptoms. This resulted in a higher need to remain close to a toilet and, as a consequence, more limitation of daily activities because of bowel symptoms and decreased social functioning. Vaginal brachytherapy provides a better QOL, and should be the preferred treatment from a QOL perspective.

scholarly journals Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS

2022 ◽  
Vol 11 (2) ◽  
pp. 441
Author(s):  
Laura Quellhorst ◽  
Grit Barten-Neiner ◽  
Andrés de Roux ◽  
Roland Diel ◽  
Pontus Mertsch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Emotional Functioning ◽  
Psychometric Validation ◽  
Life Questionnaire ◽  
Retest Reliability ◽  
German Translation ◽  
Quality Of Life Questionnaire ◽  
Test Retest Reliability

Patients with bronchiectasis feature considerable symptom burden and reduced health-related quality of life (QOL). We provide the psychometric validation of the German translation of the disease-specific Quality of Life Questionnaire-Bronchiectasis (QOL-B), version 3.1, using baseline data of adults consecutively enrolled into the prospective German bronchiectasis registry PROGNOSIS. Overall, 904 patients with evaluable QOL-B scores were included. We observed no relevant floor or ceiling effects. Internal consistency was good to excellent (Cronbach’s α ≥0.73 for each scale). QOL-B scales discriminated between patients based on prior pulmonary exacerbations and hospitalizations, breathlessness, bronchiectasis severity index, lung function, sputum volume, Pseudomonas aeruginosa status and the need for regular pharmacotherapy, except for Social Functioning, Vitality and Emotional Functioning scales. We observed moderate to strong convergence between several measures of disease severity and QOL-B scales, except for Social and Emotional Functioning. Two-week test-retest reliability was good, with intraclass correlation coefficients ≥0.84 for each scale. Minimal clinical important difference ranged between 8.5 for the Respiratory Symptoms and 14.1 points for the Social Functioning scale. Overall, the German translation of the QOL-B, version 3.1, has good validity and test-retest reliability among a nationally representative adult bronchiectasis cohort. However, responsiveness of QOL-B scales require further investigation during registry follow-up.

Quality of life and methods of treatment of people suffering from migraine

Ból ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 27-33
Author(s):  
Piotr Moneta ◽  
Michał Kaczmarek ◽  
Michał Przybylski ◽  
Jerzy Niedzielski ◽  
Agnieszka Durko ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Health ◽  
Social Functioning ◽  
Prescription Drugs ◽  
Ad Hoc ◽  
Life Questionnaire ◽  
Somatic Pain ◽  
Sf 36 ◽  
Psychic Functioning

People with migraine often use self-treatment, which can lead to increased intensity and frequency of pain, affecting the quality of life and the level of fitness of these people. The study was carried out in a group of 100 people with migraine headaches, aged 19 to 67 years, who reported for the first time to the Migraine Treatment Center at the Neurology Clinic of the Medical University of Lodz. The subjects completed the SF-36 quality of life questionnaire, the MIDAS level of disability assessment questionnaire and the original questionnaire, which questions concerned pain and treatment. In the majority of subjects, a significant increase in severity of headaches was observed. All but one person were qualified for the 4th degree of disability (MIDAS): average of 88.7 points, average frequency – 22.11/90, intensity – 7.15/10. A positive correlation (r = 0.22) was found between the amount of prescribed drugs and the number of points in the Midas Questionnaire. Significant lost of points was observed in the SF-36 Questionnaire; Physical Health – 5.62/100, Somatic Pain – 30.79/100, Social Functioning – 40.35/100, Energy – 41.12/100, Functioning Physical – 44.51/100, Emotional Functioning – 49.33/100, General Functioning – 50.59/100 and Psychic Functioning – 54.38/100. Most of these values strongly correlated negatively with MIDAS score values: Physical Health (r = –0.33, p = 0.001), Energy (r = –0.42, p = 0.000), Psychic Functioning (r = –0.27, p = 0.006), Social Functioning (r = –0.45, p = 0.000), Somatic pain (r = –0.24, p = 0.017), General Health (r = –0.44, p = 0.000). The self-treatment of people with migraine, as well as visiting the primary care physician only is a very dangerous phenomenon. Improper treatment, both ad hoc or prophylactic, may lead to increase in the frequency and intensity of headaches, and over time to a change in the nature of migraine for a chronic pain. Treatment, initially effective due to overuse of ad hoc and non-prescription drugs, in the long-term it may lead to the development of medication overuse headache (MOH).

scholarly journals The reliability of the health related quality of life questionnaire PedsQL 3.0 cancer module in a sample of Swedish children

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Peter Sand ◽  
Anna Nilsson Kleiberg ◽  
Marizela Kljajić ◽  
Birgitta Lannering
Keyword(s):  
Quality Of Life ◽  
Convergent Validity ◽  
Life Questionnaire ◽  
Quality Of Life Inventory ◽  
Proxy Reports ◽  
Cancer Module ◽  
Pedsql 4.0 ◽  
Life Inventory ◽  
Disease Specific

Abstract Background The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument, designed to integrate generic and disease specific measures, and includes both self- and proxy-reports. The aim of the study was to assess the reliability and limited validity of the Swedish version of the disease specific Pediatric Quality of Life Inventory 3.0 Cancer Module Scales (PedsQL 3.0), in a sample of Swedish children diagnosed with cancer. Method A total of 94 families at The Queen Silvia Children’s Hospital, Sahlgrenska University participated in the study. The Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL 4.0) and the PedsQL 3.0 were administered to 63 children (aged 5–18 years) with cancer and to 94 parents of children with cancer aged 2–18 years. Results The internal consistency of the PedsQL 3.0, reached or exceeded Cronbach’s alpha values of 0.70 for both -self- and proxy-reports. The PedsQL 4.0 and PedsQL 3.0 were highly correlated (r = 0.94 for proxy-reports and r = 0.91 for self-reports), indicating convergent validity. Conclusion PedsQL 3.0 Cancer Module Scales can be used as a valuable tool for measuring cancer-specific HRQOL in child populations, both in research and in clinical practice.

scholarly journals Translation and cultural adaptation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer Module for quality of life assessment in patients with lung cancer in Brazil

2019 ◽  
Vol 45 (4) ◽  
Author(s):  
Ana Paula Ramos Marinho ◽  
Gracielle Fin ◽  
Antuani Rafael Baptistella ◽  
Rudy José Nodari Júnior ◽  
Magnus Benetti
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cultural Adaptation ◽  
Life Questionnaire ◽  
Pilot Testing ◽  
Language Version ◽  
Quality Of Life Questionnaire ◽  
European Organisation ◽  
Cancer Module

ABSTRACT Objective: To translate the European Organisation for Research and Treatment of Cancer (EORTC) 29-item Quality of Life Questionnaire-Lung Cancer Module (QLQ-LC29, developed for the assessment of quality of life in patients with lung cancer) to Portuguese, conducting a pilot study of the Portuguese-language version and adapting it for use in Brazil. Methods: For the translation, cultural adaptation, and pilot testing of the QLQ-LC29, we followed the guidelines established by the EORTC. The translation (English → Portuguese) and back-translation (Portuguese → English) were both carried out by translators, working independently, who were native speakers of one language and fluent in the other. After review, a draft version was created for pilot testing in lung cancer patients in Brazil. Results: A total of 15 patients diagnosed with lung cancer completed the Portuguese-language version of the questionnaire. At the end of the process, we conducted a structured interview to identify any patient difficulty in understanding any of the questions. The final versions were sent to the EORTC and were approved. Conclusions: The Portuguese-language version of the EORTC QLQ-LC29 appears to be a useful, important, reliable questionnaire that is a valid tool for assessing quality of life in patients with lung cancer in Brazil.

The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module

Cancer ◽  
2006 ◽  
Vol 107 (8) ◽  
pp. 1812-1822 ◽  
Author(s):  
Elfriede R. Greimel ◽  
Karin Kuljanic Vlasic ◽  
Ann-Charlotte Waldenstrom ◽  
Vlatka M. Duric ◽  
Pernille T. Jensen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module ◽  
Eortc Quality

scholarly journals The metacognitive functioning of patients with paranoid schizophrenia through the prism of emotional intelligence: a connection with cognitive deficit, clinical manifestations, social functioning and quality of life

2020 ◽  
pp. 73-82
Author(s):  
A. G. Sofronov ◽  
A. V. Trusova ◽  
I. A. Getmanenko ◽  
A. E. Dobrovol’skaya ◽  
A. N. Gvozdetckii
Keyword(s):  
Quality Of Life ◽  
Emotional Intelligence ◽  
Social Functioning ◽  
Interpersonal Relationships ◽  
Cognitive Deficit ◽  
Paranoid Schizophrenia ◽  
Clinical Manifestations ◽  
Demographic Characteristics ◽  
Life Questionnaire

Metacognitive functioning is the basis of the individual’s ideas about his ability to build relationships with other people and manage own’s social behavior. Deterioration of metacognitive functioning in schizophrenia patients, presumably due to neurocognitive deficiency and other manifestations of the disease, probably contributes to disruptions of social functioning and quality of life. The aim of this study was to assess the metacognitive functioning (MF) of patients with paranoid schizophrenia, operationalized as a cognitive ability to understand their own and other people’s emotions, and to explore the connection between social functioning (SF) and quality of life (QOL), as well as to establish logical relationships between MF with clinical indicators and socio-demographic characteristics of patients. In a sample of 300 patients with paranoid schizophrenia (age from 18 to 50 years, disease duration of at least 5 years, a total PANSS score of less than 120), MF was assessed using the Lyusin emotional intelligence test (EmIn) and the subjective assessment of interpersonal relationships (SOMO) test. Cognitive deficit was verified using a standardized battery of a Brief Assessment of Cognition in Schizophrenia (BACS). The indicators obtained using the quality of life questionnaire for schizophrenia patients (QOL-SM) and the social functioning scale (PSP) were used to create an integrated indicator that comprehensively assesses SF and QOL of schizophrenia patients (Factor B). Reliable associations of this factor with indicators obtained using the Emin method (p<0.05), SOMO (p<0.001), the PSP scale, the QOL-SM questionnaire, the BACS and PANSS scales, and also with a number of clinical-dynamic and socio-demographic characteristics were established. Significant relationships between the parameters of MF, SF and QOL were obtained, and logical relationships between MF, neurocognitive deficiency and other clinical manifestations of schizophrenia were established.

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