Benign cystic ovarian neoplasms and procoagulant potential.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15538-e15538
Author(s):  
Omer M. Iqbal ◽  
Cagatay Ersahin ◽  
Zhihong Hu ◽  
Xiuzhen Duan ◽  
Debra Hoppensteadt
Keyword(s):  
Ovarian Neoplasms ◽  
Neuron Specific Enolase ◽  
Ovarian Tumors ◽  
Saline Control ◽  
Fibrinopeptide A ◽  
Control Value ◽  
Platelet Aggregometry ◽  
Cystic Tumors ◽  
Benign Ovarian Tumors ◽  
D Dimer

e15538 Background: Ovarian cancer is one of the leading causes of increased morbidity and mortality worldwide. The fluid content of the cystic ovarian tumors has never been thoroughly analyzed. It is hypothesized that the fluid contents of the ovarian cystic tumors have procoagulant effects. Methods: Under an institutionally approved protocol, cystic fluids from ovarian neoplasms were collected (n=28) and analyzed to determine their procoagulant potential. Assays such as Thrombelastography (TEG, Helige, Germany), Platelet aggregometry (BioData, Horsham, PA), Fibrinopeptide A (FPA, Dade Behring, Marburg, Germany), Thrombin Antithrombin Complex (TAT, Dade Behring), and Zymuphen Platelet Microparticle Activity Assay (Hyphen BioMed, Neuville-Sur-Oise, France). Cerebral Array II (Randox, Crumlin, CO) was used to determine the levels of C-reactive protein (CRP), D-Dimer, Neuron Specific Enolase (NSE), Neutrophil Gelatinase-Associated Lipocalin (NGAL), soluble Tumor Necrosis Factor Receptor I (TNFRI) and Thrombomodulin. Results: The TEG parameters such as r- time, rk-time, k-time, MA, and angle were measured to be 17 , 22 , 5 , 54 mm, 55° with clear cell carcinoma, 18 , 24 , 6 , 58 , 54° with benign serous cyst compared to saline control values of 23 , 30 , 7 , 41 mm and 48° respectively. Platelet aggregometry showed increased aggregations when cystic fluids were supplemented in donor platelet rich plasma. The levels of Fibrinopeptide A were in the range of 24.1 and 56.6 ng/ml compared to a control value of 1.8 ng/ml. The TAT complexes were in the range of 6.7- 175 µg/ml compared to a control value of 0.7 ug/ml. The platelet microparticle measurements were markedly increased and were in the range of 10-45 nM for benign and malignant cystic fluids, compared to control values in the range of 2.3-6.6 nM. The results of CRP, D-Dimer, NSE, NGAL, TNFRI and TM were 9.28 mg/m (Normal=5.03) , >2000 ng/ml (N=227.34) , >120 ng/ml (N=10.50), >1229 ng/ml (N=228.16), 3.98 ng/ml (5.91) and 13.55 ng/ml (N=13.55) respectively. Conclusions: Benign ovarian tumors have prothrombogenic activity as much as the malignant tumors. Early surgical evaluation of clinically silent benign ovarian tumors should be considered.

scholarly journals PERINATAL PECULIARITIES IN WOMEN WITH BENIGN OVARIAN TUMORS

World Science ◽  
2021 ◽  
Author(s):  
Hulii D. Ya. ◽  
Boichuk O. H.
Keyword(s):  
Retrospective Analysis ◽  
Preterm Labor ◽  
Ovarian Neoplasms ◽  
First Trimester ◽  
Ovarian Tumors ◽  
First Trimester Of Pregnancy ◽  
Benign Ovarian Tumors ◽  
Adnexal Tumors ◽  
Mechanical Influence

Ovarian tumors may be found in women of any age and the period of pregnancy is no exception. Besides, this period is related to some specific adnexal tumors. A systematic use of ultrasonography in the first trimester of pregnancy has led to a wider detection of symptomless adnexal tumors. The majority of adnexal tumors diagnosed during pregnancy are accidental findings of routine examinations of pregnancy. According to various estimations, the incidence of adnexal neoplasms during pregnancy makes up from 0.19 to 8.8 %. Most of cases are diagnosed in the first trimester and their incidence gradually decreases as the period of pregnancy grows: Trimester 1 – from 21.4 to 75.7 %; Trimester 2 – from 10.9 to 44.4 %; Trimester 3 – from 4 to 22.2 %; after labor – from 0 to 7.1 %. Most of adnexal tumors during pregnancy are benign and physiological and often regress spontaneously. Depending on their size and location, ovarian tumors may be related to an adverse obstetrical result caused by mechanical influence. They increase the risk of abortion (from 0 to 6 %), preterm labor (from 5.8 to 10.4 %) and mechanical impediment to labor. In view of the above mentioned considerations, one of the objectives of our research is to make a retrospective analysis of perinatal peculiarities in women with benign ovarian neoplasms.

scholarly journals Course of labor and condition of the newborn in women affected by benign ovarian tumors

2021 ◽  
Vol 25 (3) ◽  
pp. 413-418
Author(s):  
D. Ya. Hulii ◽  
O. H. Boichuk
Keyword(s):  
Preterm Labor ◽  
Ovarian Neoplasms ◽  
Reference Group ◽  
Fetal Distress ◽  
First Trimester ◽  
Ovarian Tumors ◽  
Categorical Variables ◽  
Perinatal Complications ◽  
Basic Group ◽  
Benign Ovarian Tumors

Annotation. According to various estimations, the incidence of adnexal neoplasms during pregnancy makes up from 0.19% to 8.8%. Most of cases are diagnosed in the first trimester and their incidence gradually decreases as the period of pregnancy grows. Depending on their size and location, ovarian tumors may be related to an adverse obstetrical result caused by mechanical influence. They increase the risk of abortion (from 0 to 6%), preterm labor (from 5.8% to 10.4%) and mechanical impediment to labor. Aim – studying the peculiarities of the course of labor and the condition of the newborn of women affected by benign ovarian tumors. We have conducted a complex examination of 67 pregnant women with benign ovarian tumors and tumor-like growths found before pregnancy or in the first trimester of gestation (basic group) and 50 women presenting no ovarian neoplasms or any other severe gynecological or somatic pathology (reference group). To identify the risk factors, the basic group was divided into 2 subgroups. The condition of fetuses was assessed with the use of automated cardiotocography analysis based on the Dawes/Redman criteria, with the calculation of the short-term variability (STV). The mean and standard deviation (M ± m) were evaluated at a significance level of p <0.05. Categorical variables are presented as the absolute number of cases in the group and the frequency in percent – n (%). Tests for differences between independent samples in the case of quantitative variables were performed using Student’s t test, the Mann-Whitney rank test, and in the case of categorical variables using Fisher’s exact test. The obtained results suggest that the course of labor in women affected by benign ovarian neoplasms is characterized by an increased incidence of complications. A significant difference has been established in the incidence of cesarean sections (35.8% vs 8.0% in the reference group, р<0.05), preterm labor (28.4% vs. 6.0%, р<0.05), fetal distress (19.4% vs. 8.0%, р<0.05) and preterm rupture of membranes (17.9% vs. 6.0%, р<0.05). The incidence of almost all complications of labor in Subgroup 1 significantly exceeds the figures from the reference group and the incidence of preterm labor and fetal distress is also higher in comparison with Subgroup 2. The presence of extragenital pathology is a well-known risk factor for perinatal complications, which is also confirmed by our research. A high level of comorbidity of benign ovarian neoplasms with various extragenital diseases also accounts to a certain degree for gestational complications. Thus, pregnancy in women affected by ovarian tumors implies an increased risk of obstetrical and perinatal complications, in particular, threats of miscarriage and preterm labor. The studies of this issue lack systematization, are often controversial and fragmentary. There has been practically no research on the risk factors for such complications and the ways of their prognostication and prevention.

scholarly journals Esmolol during cardiopulmonary resuscitation reduces neurological injury in a porcine model of cardiac arrest

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Ruggeri ◽  
Francesca Nespoli ◽  
Giuseppe Ristagno ◽  
Francesca Fumagalli ◽  
Antonio Boccardo ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Porcine Model ◽  
Neuronal Degeneration ◽  
Neuron Specific Enolase ◽  
Coronary Perfusion Pressure ◽  
Neurological Injury ◽  
Saline Control ◽  
Preclinical Model ◽  
Coronary Perfusion ◽  
To Receive

AbstractPrimary vasopressor efficacy of epinephrine during cardiopulmonary resuscitation (CPR) is due to its α-adrenergic effects. However, epinephrine plays β1-adrenergic actions, which increasing myocardial oxygen consumption may lead to refractory ventricular fibrillation (VF) and poor outcome. Effects of a single dose of esmolol in addition to epinephrine during CPR were investigated in a porcine model of VF with an underlying acute myocardial infarction. VF was ischemically induced in 16 pigs and left untreated for 12 min. During CPR, animals were randomized to receive epinephrine (30 µg/kg) with either esmolol (0.5 mg/kg) or saline (control). Pigs were then observed up to 96 h. Coronary perfusion pressure increased during CPR in the esmolol group compared to control (47 ± 21 vs. 24 ± 10 mmHg at min 5, p < 0.05). In both groups, 7 animals were successfully resuscitated and 4 survived up to 96 h. No significant differences were observed between groups in the total number of defibrillations delivered prior to final resuscitation. Brain histology demonstrated reductions in cortical neuronal degeneration/necrosis (score 0.3 ± 0.5 vs. 1.3 ± 0.5, p < 0.05) and hippocampal microglial activation (6 ± 3 vs. 22 ± 4%, p < 0.01) in the esmolol group compared to control. Lower circulating levels of neuron specific enolase were measured in esmolol animals compared to controls (2[1–3] vs. 21[16–52] ng/mL, p < 0.01). In this preclinical model, β1-blockade during CPR did not facilitate VF termination but provided neuroprotection.

scholarly journals CURRENT STATE OF THE ISSUE OF BENIGN OVARIAN TUMORS DURING PREGNANCY (LITERATURE REVIEW)

2021 ◽  
pp. 150-156
Author(s):  
D. Y. Hulii ◽  
О. H. Boichuk
Keyword(s):  
Literature Review ◽  
Ovarian Tumors ◽  
Current State ◽  
Benign Ovarian Tumors

Резюме. Більшість гайдлайнів, клінічних протоколів, методичних рекомендації присвячені веденню утворень придатків поза вагітністю, а рекомендації щодо вагітних жінок залишаються мало систематизованими і не чіткими, хоча необхідність враховувати материнські і плодові наслідки ускладнює процес ведення таких новоутворень. Менеджмент пухлин придатків, виявлених під час вагітності, є суперечливим. Гінекологічна патологія у жінок завжди тією чи іншою мірою пов’язана з психологічним стресом, змінами психоемоційного стану, які можуть при тривалому стресогенному навантаженні призводити до психосоматичної патології. Крім того, з психо-соціального аспекту вагітність може розглядатися як специфічний надзвичайно емоційний стан, який може бути потужним стресором. Перинатальний материнський стрес може призвести до різних ускладнень, які можуть мати далекосяжні наслідки як для соматичного, так і для психічного функціонування новонародженого. У науковій літературі наявна достатньо велика кількість публікацій з проблеми «пухлини яєчника і вагітність», однак переважна більшість з них присвячена гінекологічним аспектам, ризику малігнізації, диференціальній діагностиці та менеджменту таких новоутворень лише в напрямку вибору між очікувальною та хірургічною тактикою та визначення термінів і обсягів операції. Незважаючи на емпіричні докази численних наслідків, пов'язаних з високим рівнем стресу та проблемами психічного здоров'я під час вагітності, оцінка психо-соціального стресу у вагітних проводиться рідко.

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