Contralateral breast cancer: Effect of stage on survival after unilateral breast cancer.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 69-69
Author(s):  
Lori Uyeno ◽  
Carolyn E. Behrendt ◽  
Laura Kruper ◽  
Steven L. Chen ◽  
Courtney Vito
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Breast Cancer Survivors ◽  
Contralateral Breast Cancer ◽  
Prophylactic Mastectomy ◽  
Early Stage ◽  
Contralateral Breast ◽  
Advanced Stage ◽  
The Impact

69 Background: Contralateral breast cancer (CBC) is the most common malignancy among breast cancer survivors. We investigated the impact of CBC on overall survival (OS) after unilateral primary breast cancer (UPBC) in women treated with mastectomy. Methods: Using the Surveillance Epidemiology End Results registry, we identified women age 25-80 diagnosed 1998-2006 with UPBC stage 0-III, treated with mastectomy and free of CBC at 1-year landmark. Subjects were split into test and validation samples. Follow-up continued until the earliest occurrence: death, end of 2008, or age 85. Primary risk factor was incident CBC, a time-dependent variable categorized as advanced-stage (IIB-IV), early-stage (0-IIA), or none. Proportional hazards regression adjusted for primary tumor characteristics, treatment including contralateral prophylactic mastectomy (CPM), demographics, and aging. Results: Subjects (n= 109,411, age 53.7[+12.7] years at UPBC diagnosis) were followed median 51 months. Most UPBC were early stage (63%), moderately/poorly differentiated (78%), ER+PR+ (52%). Few (9.8%) women underwent CPM at primary diagnosis. Incident CBC (n=867, 0.79%) was diagnosed median 23.5 (95% CI 1.2-72) months beyond the 1-year landmark. Test and validation samples did not differ. Only CBC of stage IIB-IV increased mortality; early stage CBC had no effect on OS. Among CBC cases, advanced stage was independently associated with aggressive UPBC (more positive nodes; larger tumor; greater extension), African-American race, and shorter time from UPBC. Conclusions: Among women who undergo mastectomy +/-CPM for UPBC, few develop CBC, which impacts survival only when diagnosed at advanced stage. Efforts to improve survival after UPBC should emphasize earlier detection and prevention of advanced-stage CBC, especially in African-American women and women with more aggressive UPBC. [Table: see text]

Mammography screening and detection of early stage breast cancer in Hispanic and African American women at a Minnesota safety net healthcare system.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18074-e18074
Author(s):  
Daniel Fellows Pease ◽  
David T. Gilbertson ◽  
Andres Wiernik
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Healthcare System ◽  
Early Stage ◽  
Screening Mammography ◽  
Advanced Stage ◽  
American Women ◽  
Younger Age ◽  
Caucasian Women

e18074 Background: Approximately 12% of breast cancer cases occur in women younger than 50 years, per SEER data from 2012. Hispanic women are known to present at a younger age and African American women with more advanced stage disease. In this study, we describe the impact of age and race on the initial presentation of breast cancer among minority women treated at the Hennepin Healthcare System (HHS) in the state of Minnesota. Methods: A single-institution retrospective analysis of data from our electronic health record of all breast cancer diagnoses from 2010-2015. Cases were compared by age ( < 50 or > 50 years), race (Caucasian, African American, Hispanic, other), stage (AJCC 7th edition), and method of diagnosis (self-reported mass or screening mammography). Results: A total of 315 breast cancer diagnoses occurred at HHS from 2010-2015. In our cohort, 29% of all breast cancer cases were diagnosed in women < 50yrs. Hispanic and African American women had higher rates of diagnosis at < 50yrs compared to Caucasian women (38.9% vs 37.1% vs 18.1 respectively, p < 0.05). Early stage cancer (stage 0 or I) accounted for most diagnoses in those > 50yrs (54.8%), while advanced stage (stage II-IV) was more prevalent in the < 50yrs age group (59.5%) (p < 0.05). Of all women diagnosed with breast cancer, 63% presented with a self-reported mass and 37% were diagnosed by screening mammography. Hispanics and African American women had a higher rate of presentation with a self-reported mass (74% and 66% respectively) compared to Caucasian women (55%). Women with breast cancer < 50yrs were more likely to present with a self-reported mass than women > 50yrs (80% vs 55%, p < 0.05). 92% of Hispanic and 80% of African American women < 50yrs presented with a self-reported mass, compared to 62% of Caucasian women (p = 0.095). Conclusions: At our institution, Hispanic and African American women are diagnosed at a significantly younger age than Caucasian women, and those diagnosed at a younger age have more advanced disease. Presenting with a self-reported mass is very common for young non-Caucasian women. Whether screening mammography can be better utilized to change these trends requires further study.

scholarly journals Contralateral Breast Cancer and Thromboembolic Events in African American Women Treated With Tamoxifen

2004 ◽  
Vol 96 (23) ◽  
pp. 1762-1769 ◽  
Author(s):  
W. McCaskill-Stevens ◽  
J. Wilson ◽  
J. Bryant ◽  
E. Mamounas ◽  
L. Garvey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Thromboembolic Events ◽  
American Women

Health Behaviors and Breast Cancer: Experiences of Urban African American Women

2006 ◽  
Vol 33 (5) ◽  
pp. 604-624 ◽  
Author(s):  
Melinda R. Stolley ◽  
Lisa K. Sharp ◽  
Anita M. Wells ◽  
Nolanna Simon ◽  
Linda Schiffer
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Health Behavior ◽  
Health Behaviors ◽  
Cancer Survivors ◽  
African American Women ◽  
Breast Cancer Survivors ◽  
Behavior Changes ◽  
American Women ◽  
Health Behavior Changes

Breast-cancer survival rates are lower among African American women compared to White women. Obesity may contribute to this disparity. More than 77% of African American women are overweight or obese. Adopting health behaviors that promote a healthy weight status may be beneficial because obesity increases risk for recurrence. Studies among White breast-cancer survivors indicate that many make health behavior changes after diagnosis. This cross-sectional pilot study collected quantitative and qualitative data on the attitudes, beliefs, barriers, and facilitators related to health behavior changes in 27 overweight/obese African American breast-cancer survivors. Results indicated that most participants reported making dietary changes since their diagnosis, and some had increased their physical activity. Focus groups provided rich details on the barriers and facilitators for behavior change. These results begin to address the significant gap in our knowledge of African American breast-cancer survivors' health behaviors and underscore the need for culturally competent health behavior interventions.

The Impact of a Family History of Breast Cancer on Screening Practices and Attitudes in Low-Income, Rural, African American Women

2003 ◽  
Vol 12 (8) ◽  
pp. 779-787 ◽  
Author(s):  
Delia Smith West ◽  
Paul G. Greene ◽  
Polly P. Kratt ◽  
Leavonne Pulley ◽  
Heidi L. Weiss ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Family History ◽  
African American Women ◽  
Low Income ◽  
American Women ◽  
Screening Practices ◽  
History Of ◽  
The Impact

Triple-negative early-stage breast cancer in African American women: A fuel to the fire

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 11039-11039 ◽  
Author(s):  
A. M. Khan ◽  
I. Sabnani ◽  
P. Tsang ◽  
D. A. Baran ◽  
E. Rogers-Phillips ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Triple Negative ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
American Women
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