Treatment patterns for patients with localized (T1-T2) penile squamous cell carcinoma in the United States.

332 Background: The standard treatment for patients with localized penile squamous cell carcinoma is penectomy, which is associated with high psychosocial morbidity. Organ preservation using radiation therapy is an alternative. To our knowledge, this is the first population-based patterns of care study in this disease for a modern cohort of men. Methods: Caucasian (CA, N=1,270) and African American (AA, N=139) patients diagnosed with localized cancer from 2000-2009 were included from the Surveillance, Epidemiology and End Results (SEER) database. Treatments were categorized into ablative therapies (e.g. laser, electrocautery), surgical resection, or radiation therapy (including external beam and brachytherapy). Multivariate logistic regression assessed factors associated with receipt of radiation therapy as primary treatment. Results: 57% of patients were married. The vast majority of patients receive surgical resection, with about 1% receiving primary radiation therapy (Table). Patterns of care were not significantly different among AA and CA patients (p=.95). Multivariable analysis including diagnosis year, marital status, age, race and SEER region did not show any covariate significantly associated with receipt of primary radiation treatment. Conclusions: Surgical resection is the predominant treatment for patients with localized penile cancer in the United States, with very few patients receiving primary radiation therapy. [Table: see text]