Mantle cell lymphoma: Toll-like receptors (TLRs) and B-cell receptor (BCR) gene expression analysis for identification of a distinct BCR-activated subset, with germinal center signature and indolent biology.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 8585-8585
Author(s):  
Ariz Akhter ◽  
Fahad Farooq ◽  
Etienne Mahe ◽  
Meer-Taher Shabani-Rad ◽  
Lesley Street ◽  
...  
Keyword(s):  
Gene Expression ◽  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Expression Analysis ◽  
Germinal Center ◽  
Gene Expression Analysis ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell

Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma

Oncogene ◽  
2020 ◽  
Vol 39 (14) ◽  
pp. 2934-2947
Author(s):  
Gregory Lazarian ◽  
Chloe Friedrich ◽  
Anne Quinquenel ◽  
Julie Tran ◽  
Souhail Ouriemmi ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Target Genes ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Receptor Signaling ◽  
Mantle Cell ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Concomitant high expression of Toll-like receptor (TLR) and B-cell receptor (BCR) signalling molecules has clinical implications in mantle cell lymphoma

2015 ◽  
Vol 35 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Ariz Akhter ◽  
Lesley Street ◽  
Sunita Ghosh ◽  
Bruce F. Burns ◽  
Ghaleb Elyamany ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
High Expression ◽  
Clinical Implications ◽  
Toll Like Receptor ◽  
Signalling Molecules ◽  
Mantle Cell

scholarly journals Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Haematologica ◽  
2010 ◽  
Vol 95 (11) ◽  
pp. 1865-1872 ◽  
Author(s):  
F. Baran-Marszak ◽  
M. Boukhiar ◽  
S. Harel ◽  
C. Laguillier ◽  
C. Roger ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Signaling Pathways ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell

scholarly journals Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling

2011 ◽  
Vol 34 (2) ◽  
pp. 141-153 ◽  
Author(s):  
Chiara Pighi ◽  
Ting-Lei Gu ◽  
Irene Dalai ◽  
Stefano Barbi ◽  
Claudia Parolini ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Proteomic Analysis ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Sorafenib Inhibits Cell Migration and Stroma-Mediated Bortezomib Resistance by Interfering B-cell Receptor Signaling and Protein Translation in Mantle Cell Lymphoma

2012 ◽  
Vol 19 (3) ◽  
pp. 586-597 ◽  
Author(s):  
Sílvia Xargay-Torrent ◽  
Mónica López-Guerra ◽  
Arnau Montraveta ◽  
Ifigènia Saborit-Villarroya ◽  
Laia Rosich ◽  
...  
Keyword(s):  
Cell Migration ◽  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Protein Translation ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Identification and gene expression analysis of the side population subclone in mantle cell lymphoma

2017 ◽  
Vol 35 ◽  
pp. 284-284
Author(s):  
V. Kuci Emruli ◽  
R. Rosenquist ◽  
C. Sundström ◽  
E. Cordero ◽  
K. Pietras ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mantle Cell Lymphoma ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Cell Lymphoma ◽  
Side Population ◽  
Mantle Cell

scholarly journals Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2

2021 ◽  
Vol 5 (1) ◽  
pp. 185-197
Author(s):  
Wenjun Wu ◽  
Weige Wang ◽  
Carrie A. Franzen ◽  
Hui Guo ◽  
Jimmy Lee ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Xenograft Model ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell ◽  
Bcr Signaling

Abstract Inhibition of the B-cell receptor (BCR) signaling pathway is highly effective in B-cell neoplasia through Bruton tyrosine kinase inhibition by ibrutinib. Ibrutinib also disrupts cell adhesion between a tumor and its microenvironment. However, it is largely unknown how BCR signaling is linked to cell adhesion. We observed that intrinsic sensitivities of mantle cell lymphoma (MCL) cell lines to ibrutinib correlated well with their cell adhesion phenotype. RNA-sequencing revealed that BCR and cell adhesion signatures were simultaneously downregulated by ibrutinib in the ibrutinib-sensitive, but not ibrutinib-resistant, cells. Among the differentially expressed genes, RAC2, part of the BCR signature and a known regulator of cell adhesion, was downregulated at both the RNA and protein levels by ibrutinib only in sensitive cells. RAC2 physically associated with B-cell linker protein (BLNK), a BCR adaptor molecule, uniquely in sensitive cells. RAC2 reduction using RNA interference and CRISPR impaired cell adhesion, whereas RAC2 overexpression reversed ibrutinib-induced cell adhesion impairment. In a xenograft mouse model, mice treated with ibrutinib exhibited slower tumor growth, with reduced RAC2 expression in tissue. Finally, RAC2 was expressed in ∼65% of human primary MCL tumors, and RAC2 suppression by ibrutinib resulted in cell adhesion impairment. These findings, made with cell lines, a xenograft model, and human primary lymphoma tumors, uncover a novel link between BCR signaling and cell adhesion. This study highlights the importance of RAC2 and cell adhesion in MCL pathogenesis and drug development.

scholarly journals The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells

HemaSphere ◽  
2021 ◽  
Vol 5 (8) ◽  
pp. e620
Author(s):  
Moritz Bewarder ◽  
Maximilian Kiefer ◽  
Helene Will ◽  
Kathrin Olesch ◽  
Clara Moelle ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Lymphoma Cells ◽  
Mantle Cell
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