Depression in women breast cancer patients receiving radiation therapy: A pilot study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12546-e12546
Author(s):  
Fang Chen ◽  
Hao Yu ◽  
Caining Zhao ◽  
Fan Zhang ◽  
Yaqing Nong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Menopausal Status ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
N Stage

e12546 Background: The purpose of this study is to study depression and its risk factors at baseline and explore the changes of depression status during the course of radiation therapy in breast patients. Methods: This is part of a prospective study of treatment toxicity and quality of life. Breast cancer patients, aged 18-year old and above requiring adjuvant radiation therapy were eligible. The primary endpoint depression was assessed by a self-addressed “depression” questionnaires according to NCI “PROMIS”. The Questionnaires were completed one day prior to, during and at the end of treatment. Patient, tumor and prior treatment factors were collected. Cancer specific symptoms were collected by treating physicians and graded according to NIH/NCI CTCAE v4.0. The variables of our interest included age, menopausal status, N-stage,pathology stage, immunohistochemisty, surgical approaches,margin,prior treatments and radiation models. Data are presented as mean (95% confidence interval) unless otherwise specified. Statistical significances were tested using generalized linear model, pearson correlation and t-text. Ps less than 0.05 were considered to be significant. Results: Between July 2019 and January 2020, a total of 185 patients enrolled and completed the PROMIS questionaires. Before RT commencement, 50/185 (27.0%) had some levels of depressive feeling including 40/185 (21.6%), 10/185 (5.4%), and 0/185 (0%) patients for “rarely” (score = 5-8), “sometimes” (score = 9-12), “often” (score = 13-16), and “always” (score 17-20), respectively. Interestingly, N stage and pathology staging group were significantly associated with the depression at baseline while age, menopausal status, immunohistochemistry, previous chemo cycles, chemo regimens and anti-Her2 taget therapy were not. At the end of RT, 51/149 (34.2%) patients had depression level changed, though the absolute lumped scores of depression did not change significantly (p = 0.437). Changes in depression during were significantly associated with menopausal status (p = 0.015) while grade 2 and above toxicities were not (p = 0.421). Conclusions: Depression feeling is not uncommon in breast patients receiving adjuvant radiation. Future study may identify patients with depression and associated risk factors so that proper intervention may be applied to improve long-term survival and quality of life in patients.

scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2017 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Mylin A. Torres
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Breast Cancer Patients ◽  
Sf 36 ◽  
A Prospective Study

Abstract Purpose: The purpose of this study was to examine the impact of radiation therapy on quality of life (QOL) of breast cancer patients during and until 1 year after radiation therapy treatment. Methods and materials: Thirty-nine breast cancer patients treated with breast-conserving surgery were enrolled in a prospective study before whole breast radiation therapy (50 Gy plus a 10-Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiation therapy, and 6 weeks and 1 year after radiation therapy. The primary outcome variable was quality of life (QOL), measured by Medical Outcomes Study 36-Item Short Form Version 2 (SF-36). Risk factors potentially associated with total SF-36 scores and its physical and mental health component summary scores were also examined, including age, race, marital status, smoking history, menopausal status, endocrine treatment, cancer stage, sleep abnormalities (assessed by the Pittsburgh Sleep Quality Index), and perceived stress levels (assessed by the Perceived Stress Scale). Mixed effect modeling was used to observe QOL changes during and after radiation therapy. Results: Total SF-36 scores did not change significantly during and up to 1 year after radiation therapy compared with baseline measures. Nevertheless, increased body mass index (BMI) and increased perceived stress were predictive of reduced total SF-36 scores over time (P Z .0064, and P < .0001, respectively). In addition, increased BMI was predictive of reduced physical component summary scores of the SF-36 (P Z .0011), whereas increased perceived stress was predictive of worse mental component summary scores (P < .0001). Other proposed potential risk factors including skin toxicity from radiation therapy were not significant. Conclusions: Radiation therapy did not worsen QOL in breast cancer patients. However, preradiation therapy patient characteristics including BMI and perceived stress may be used to identify women who may experience decreased physical and mental function during and up to 1 year after radiation therapy. Copyright 2016 the Authors. Published by EJCS on behalf of Uptodate In Medicine LLC Health Sciences Publishing. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

scholarly journals Quality of life and related risk factors after breast reconstruction in breast cancer patients

Gland Surgery ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 767-774
Author(s):  
Xiaoqing Wang ◽  
Kepeng Zhu ◽  
Liang Ren ◽  
Hanbing Li ◽  
Shuai Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Breast Reconstruction ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Related Risk

NeuroCog-FX study: A multicenter cohort study on cognitive dysfunction in patients with early breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10061-10061 ◽  
Author(s):  
Oliver Rick ◽  
Monika Reuß-Borst ◽  
Timm Dauelsberg ◽  
Holger Hass ◽  
Volker König ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Cognitive Function ◽  
Cancer Patients ◽  
Cognitive Dysfunction ◽  
Clinical Parameters ◽  
Breast Cancer Patients ◽  
Oncological Rehabilitation

10061 Background: Many breast cancer patients complain about cognitive dysfunction (CD) with mnestic and attentional deficits. These complaints persist even after completion of therapy in approximately one third of the patients and affects both social life and working capacity. The exact nature and genesis of CD in breast cancer patients is still not fully understood and risk factors are not yet described. Methods: To determine CD and risk factors, we used the computer-based neuropsychological test NeuroCog-FX during a three weeks oncological rehabilitation in breast cancer patients. Eight subtests addressed attention, working memory, verbal and figural memory, and language. Test duration was < 30 minutes. A cognitive deficit was diagnosed if at least one subtest was clearly below average (score < M - 1.5 SD) of the normative age group. The data on cognitive function were correlated with the level of depression (PHQ-9 test), QoL (EORTC QLQ-30) and clinical parameters (nodal status, chemo-/radiotherapy and endocrine therapy). Results: From February 2013 to December 2014 a total of 476 patients were recruited in 9 oncological rehabilitation centers in Germany. NeuroCog-FX was used to examine 439 patients. Median age was 50 years (range: 24-62 years); 93% of patients had early tumor stage (T0-T2) and 67% were node-negative. Sixty-one percent of the patients received chemotherapy while 84% of the subjects underwent radiotherapy. CD was found in 59% and a moderate to severe depression in 38% of the patients. The severity of depression was correlated with slower reaction times and reduced verbal memory performance. These two cognitive parameters were also associated with a reduced global health status and a reduced physical function score on the EORTC-QLQ30 questionnaire suggesting an impact of cognitive deficits on quality of life. Cognitive function was not associated with type of treatment or node status. Conclusions: In this large and homogeneous cohort of breast cancer patients, CD has been shown in most of the subjects using a valid test method. CD was associated with depression and reduced quality of life. Neither tumor therapy nor other clinical parameters had a significant impact on development of CD.

“QUALITY OF LIFE ASSESSMENT AT VARIOUS STAGES OF TREATMENT OF BREAST CANCER PATIENTS IN INDIAN DEMOGRAPHICS”

2021 ◽  
pp. 66-68
Author(s):  
Shivakumari Devi ◽  
Uday Pratap Shahi ◽  
Purnima Awasthi ◽  
Ganeshkumar Patel
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Coming Out ◽  
Well Being ◽  
Demographic Characteristics ◽  
Sexual Life ◽  
Breast Cancer Patients

AIM: - The aim of this study is to assess the QOL in breast cancer patients during different stages, mastectomy surgery, chemotherapy, radiation therapy. To evaluate quality of life of females after mastectomy and factors affecting the same in various domain of life MATERIAL AND METHOD:-60 breast cancer patients (mastectomy=20, chemotherapy=20, radiotherapy=20) from May 2019 to Nov 2020. Translated version of a customized questionnaire based on the Royal College of surgeons, quality of life Instrument- Breast cancer patient version (QOL-BC), self-designed questionnaire. Questionnaire is used assess quality of life these patients. Prospective study after whole breast radiation therapy (50Gy plus a 10Gy boost). Patient data collected before beginning of cancer treatment, and at every stage of treatment surgery, chemo and radiation and 3 months after complete treatment. During the interview, we collected information on demographic characteristics, treatment method for breast cancer patient's mastectomy, chemotherapy, and radiotherapy social well-being and quality of life chemotherapy & radiotherapy patients. Statistical analysis performed for the demographic characteristics of social well-being quality of life of mastectomy, chemo therapy and radiotherapy status were summarized using frequency and percentage for categorical variables, means and standard deviation (SD) for continuous variables. Analysis of variance (ANOVA) was used to compare mean of the total QOL scores in three study groups. Data analyses was done using SPSS version 16.0 software. RESULT:- For mastectomy surgery body image, pain, activity daily living, treatment, the mean QOL score coming out to be above the 50 percent of total QOL score, psychological aspect almost 50 percent score and sexual life less than 50 percent score .QOL chemotherapy total score coming out almost 50 percent and radiotherapy less than 50 percent score. CONCLUSION: Adequate social support from family members, friends and neighbors, and higher scores of social well-beings, were associated with signicantly improved quality of life Breast cancer patients.

scholarly journals Factors Influencing Quality of Life in Breast Cancer Patients Six Months after the Completion of Chemotherapy

Diseases ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
Maria Lavdaniti ◽  
Dimitra Owens ◽  
Polixeni Liamopoulou ◽  
Kalliopi Marmara ◽  
Efrosini Zioga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Menopausal Status ◽  
Bodily Pain ◽  
Breast Cancer Patients ◽  
Convenience Sample ◽  
Greek City ◽  
Physical Role

Purpose: To assess breast cancer patients’ quality of life six months after the completion of adjuvant chemotherapy, and to investigate factors affecting this. Methods: The study was conducted in one large hospital located in a major Greek city. A convenience sample of 61 breast cancer outpatients was recruited. A questionnaire, including the SF-36 scale and questions regarding demographic and clinical information, was used to collect data. Results: The mean age of the patients was 51.52 ± 12.10. The effect of age on the physical role was significant (p = 0.003). Τhe effect of menopausal status on physical role was also found to be significant (p = 0.003); this might be explained by age. Regarding the treatment type, patients who received hormone therapy in addition to surgery and chemotherapy reported a significantly higher quality of life in terms of bodily pain (p = 0.04) and vitality (p = 0.04) than patients who underwent only surgery and chemotherapy. Conclusions: Quality of life is affected by factors such as age, menopausal status, and previous therapy. Health care professionals should be more aware of the factors that influence the quality of life domains (physical role, bodily pain, vitality) within this group of cancer patients in order to meet their needs following acute treatment.

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