scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2017 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Mylin A. Torres
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Breast Cancer Patients ◽  
Sf 36 ◽  
A Prospective Study

Abstract Purpose: The purpose of this study was to examine the impact of radiation therapy on quality of life (QOL) of breast cancer patients during and until 1 year after radiation therapy treatment. Methods and materials: Thirty-nine breast cancer patients treated with breast-conserving surgery were enrolled in a prospective study before whole breast radiation therapy (50 Gy plus a 10-Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiation therapy, and 6 weeks and 1 year after radiation therapy. The primary outcome variable was quality of life (QOL), measured by Medical Outcomes Study 36-Item Short Form Version 2 (SF-36). Risk factors potentially associated with total SF-36 scores and its physical and mental health component summary scores were also examined, including age, race, marital status, smoking history, menopausal status, endocrine treatment, cancer stage, sleep abnormalities (assessed by the Pittsburgh Sleep Quality Index), and perceived stress levels (assessed by the Perceived Stress Scale). Mixed effect modeling was used to observe QOL changes during and after radiation therapy. Results: Total SF-36 scores did not change significantly during and up to 1 year after radiation therapy compared with baseline measures. Nevertheless, increased body mass index (BMI) and increased perceived stress were predictive of reduced total SF-36 scores over time (P Z .0064, and P < .0001, respectively). In addition, increased BMI was predictive of reduced physical component summary scores of the SF-36 (P Z .0011), whereas increased perceived stress was predictive of worse mental component summary scores (P < .0001). Other proposed potential risk factors including skin toxicity from radiation therapy were not significant. Conclusions: Radiation therapy did not worsen QOL in breast cancer patients. However, preradiation therapy patient characteristics including BMI and perceived stress may be used to identify women who may experience decreased physical and mental function during and up to 1 year after radiation therapy. Copyright 2016 the Authors. Published by EJCS on behalf of Uptodate In Medicine LLC Health Sciences Publishing. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

Depression in women breast cancer patients receiving radiation therapy: A pilot study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12546-e12546
Author(s):  
Fang Chen ◽  
Hao Yu ◽  
Caining Zhao ◽  
Fan Zhang ◽  
Yaqing Nong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Menopausal Status ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
N Stage

e12546 Background: The purpose of this study is to study depression and its risk factors at baseline and explore the changes of depression status during the course of radiation therapy in breast patients. Methods: This is part of a prospective study of treatment toxicity and quality of life. Breast cancer patients, aged 18-year old and above requiring adjuvant radiation therapy were eligible. The primary endpoint depression was assessed by a self-addressed “depression” questionnaires according to NCI “PROMIS”. The Questionnaires were completed one day prior to, during and at the end of treatment. Patient, tumor and prior treatment factors were collected. Cancer specific symptoms were collected by treating physicians and graded according to NIH/NCI CTCAE v4.0. The variables of our interest included age, menopausal status, N-stage,pathology stage, immunohistochemisty, surgical approaches,margin,prior treatments and radiation models. Data are presented as mean (95% confidence interval) unless otherwise specified. Statistical significances were tested using generalized linear model, pearson correlation and t-text. Ps less than 0.05 were considered to be significant. Results: Between July 2019 and January 2020, a total of 185 patients enrolled and completed the PROMIS questionaires. Before RT commencement, 50/185 (27.0%) had some levels of depressive feeling including 40/185 (21.6%), 10/185 (5.4%), and 0/185 (0%) patients for “rarely” (score = 5-8), “sometimes” (score = 9-12), “often” (score = 13-16), and “always” (score 17-20), respectively. Interestingly, N stage and pathology staging group were significantly associated with the depression at baseline while age, menopausal status, immunohistochemistry, previous chemo cycles, chemo regimens and anti-Her2 taget therapy were not. At the end of RT, 51/149 (34.2%) patients had depression level changed, though the absolute lumped scores of depression did not change significantly (p = 0.437). Changes in depression during were significantly associated with menopausal status (p = 0.015) while grade 2 and above toxicities were not (p = 0.421). Conclusions: Depression feeling is not uncommon in breast patients receiving adjuvant radiation. Future study may identify patients with depression and associated risk factors so that proper intervention may be applied to improve long-term survival and quality of life in patients.

scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2016 ◽  
Vol 1 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Jennifer Felger ◽  
Donna Mister ◽  
Tian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Prospective Study ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
A Prospective Study

Quality of life and patient satisfaction in breast cancer patients after immediate breast reconstruction: a prospective study

The Breast ◽  
2005 ◽  
Vol 14 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Elisabeth Edström Elder ◽  
Yvonne Brandberg ◽  
Tina Björklund ◽  
Richard Rylander ◽  
Jakob Lagergren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Patient Satisfaction ◽  
Breast Reconstruction ◽  
Prospective Study ◽  
Cancer Patients ◽  
Immediate Breast Reconstruction ◽  
Breast Cancer Patients ◽  
A Prospective Study

scholarly journals Nutritional Status and Quality of Life in Breast Cancer Patients in Karawaci General Hospital

2016 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
ANDREE KURNIAWAN ◽  
NATA PRATAMA HARDJO LUGITO
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Physical Functioning ◽  
Short Form ◽  
Subjective Global Assessment ◽  
Breast Cancer Patients ◽  
Sf 36

ABSTRACTCancer is related to a deterioration of nutritional status and quality of life (Qol), but the extent of these conditions in patients with breast cancer has not been studied well. Malnutrition is prevalent among cancer patients and maybe correlated with altered quality of life. The aim of this study is to evaluate the association of QoL and nutritional status after breast cancer diagnosed. Nutritional status was evaluated with Patient Generated Subjective Global Assessment and QoL using Short form 36 (SF-36) and also with the specific module for breast cancer patients. A consecutive sampleof twenty two patients diagnosed with breast cancer was evaluated. The associations of QoL with stadium and nutrition status were evaluated using T-test analysis. The mean of body mass index was 21.3 kg/m2. Fifty percent patient have menopause. Most patients were stage II (77.3%), the others stage III (18.2%) and stage I (4.5%). Sixty eight point two percent had risk of malnutrition. The stadium of tumor was significantly related to physical functioning (p < 0.000), physical limitation (p < 0.024), emotional limitation (p < 0.013), well-being (p < 0.020), health changes (p < 0.010). Thestatus of nutrition was significantly related to physical functioning (p < 0.001), loss of energy (p < 0.010) and general health (p <0.005). For Conclusion, the status of nutrition breast cancer patients were related to QoL especially physical functioning, loss of energy and general health after they were diagnosed.ABSTRAKKanker sangat terkait dengan perburukan status nutrisi dan kualitas hidup. Namun demikian, belum banyak studi yang yang melaporkan masalah nutrisi dan kulitas hidup pada kanker payudara. Malnutrisi sering ditemukan pada kanker dan mungkin terkait dengan perubahan kulaitas hidup. Tujuan penelitian ini adalah untuk mengevaluasi hubungan antara kualitas hidup dengan status nutrisi setelah kanker payudara terdiagnosis. Evaluasi status nutrisi dilakukan dengan Patient Generated Subjective Global Assessment dan kualitas hidup dengan Short form 36 (SF-36) sertakarakteristik pada kanker payudara. Sampel diambil dengan teknik konsekutif terhadap 22 pasien yang terdiagnosis kanker payudara. Hubungan kualitas hidup dengan stadium kanker dan status nutrisi dinilai menggunakan analisis T-test. Indeks massa tubuh rata-rata adalah 21,3 kg/m2. Lima puluh pasien telah menopause. Terbanyak adalah stadium 2 (77,3%), stadium 3 (18,2%), dan stadium 1 (4,5%). Enam puluh dua koma dua persen berisiko malnutrisi. Stadium tumor secara bermakna berhubungan dengan fungsi fisik (p <0,000), keterbatasan fisik (p<0,024), keterbatasan emosi(p<0,013), rasa nyaman (p<0,020), dan perubahan kesehatan (p<0,000). Status nutrisi berhubungan secara bermakna dengan fungsi fisik (p<0,001), kehilangan energi (p<0,010), dan kesehatan secara umum (p<0,005). Simpulan, status nutrisi pasien kanker payudara berhubungan dengan kualitas hidup, terutama fungsi fisik, kehilangan energi, status kesehatan umum setelah mereka terdiagnosis.

ASSESSMENT OF QUALITY OF LIFE IN BREAST CANCER PATIENTS - USING FACT-G, SF-36 AND QLQ-C30 QUESTIONNAIRES

2011 ◽  
pp. 98-105
Author(s):  
Nguyen Thai Bao Nguyen ◽  
Dinh Tung Nguyen ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Cancer Staging ◽  
Care Quality ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Sf 36 ◽  
Quality Of Life Index

Background: The assessment and improvement of Quality of life (QoL) of breast cancer and other diseases patients have been of great concern for a long time. This research is to assessing the QoL of breast cancer patients using the popular and recommended instruments, the FACT-G, SF-36 and QLQ-C30 (including QLQ-BR23). Methods and Materials: A cross-sectional descriptive study on breast cancer patients receiving surgical, chemotherapy and radiotherapy, using FACT-G, SF-36 and QLQ-C30 to evaluate their quality of life. The assessment is mainly based on the patients’ own feelings. Results: Average age: 48.4±13.1. Most patients in the sample are from stage IIA to stage IIIB (TNM Cancer Staging, by AJCC 2010). Quality of life index using FACT-G is 60.6±5.1, using SF-36 is 46.5±11.0 in physical health and 53.1±14.8 in mental health, using QLQ-C30 is 53.1±21.0. Conclusion: The QoL assessment by using these instruments shows results mostly in average on many aspects. The screening needs to be improved for better early-detection and treatment, especially in mental care. Quality of life of breast cancer patients reasearches should be paid more attention and widely expanded.

A prospective study on behavioral symptoms’ impact to the quality of life in patients with early-stage cancer receiving radiotherapy.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 46-46
Author(s):  
Canhua Xiao ◽  
Jennifer Felger ◽  
Donna Mister ◽  
Tian Liu ◽  
Andrew H. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Prospective Study ◽  
Cancer Patients ◽  
Early Stage ◽  
Behavioral Symptoms ◽  
Breast Cancer Patients ◽  
A Prospective Study ◽  
Over Time

46 Background: Fatigue, sleep problems, and depression are the most common behavioral symptoms experienced by breast cancer patients. The purpose of this study was to examine these behavioral symptoms’ impact on quality of life (QOL) for early stage breast cancer patients receiving radiotherapy (RT). Methods: This was a prospective study of 46 patients receiving whole breast RT (50 Gy plus a 10 Gy boost) following lumpectomy. Data were collected at pre-RT, week 6 of RT, and 6-weeks post-RT. QOL was measured by Short Form-36, fatigue by Multidimensional Fatigue Inventory, sleep by Pittsburgh Sleep Quality Index, depression by Inventory for Depressive Symptomatology-Self-Rated, and stress by Perceived Stress Scale. No patients were treated with chemotherapy. Demographic/clinical variables, including age, race, marriage, smoking history, hormone treatment, and cancer stage, were collected at the time of enrollment. Mixed effect modeling was utilized to observe behavioral symptoms’ impact on QOL over time. Results: Fatigue and depression, along with stress, had significant impact on QOL after controlling for body mass index (BMI; the only one significant demographic/clinical variable; see Table). Patients with more fatigue, depression, or stress were more likely to have worse QOL during and post-RT. Patients having a higher BMI at baseline also reported worse QOL over time. Sleep was significantly correlated with QOL in univariate analyses, while this effect disappeared in multivariate models. Conclusions: Behavioral symptoms, in particular fatigue and depression, along with stress, have significant impact on the QOL of early breast cancer patients’ receiving RT. Future research on the underlying biological mechanisms will improve our understanding of these symptoms and their relationships, which will help to find potential targets for multiple related symptoms and, ultimately, improve patients’ QOL. [Table: see text]

scholarly journals Quality of life and related risk factors after breast reconstruction in breast cancer patients

Gland Surgery ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 767-774
Author(s):  
Xiaoqing Wang ◽  
Kepeng Zhu ◽  
Liang Ren ◽  
Hanbing Li ◽  
Shuai Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Breast Reconstruction ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Related Risk

scholarly journals Metastatic breast cancer: do current treatments improve quality of life? A prospective study

2006 ◽  
Vol 124 (4) ◽  
pp. 203-207 ◽  
Author(s):  
Fernanda Amado ◽  
Maria Teresa Cruz Lourenço ◽  
Daniel Deheinzelin
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Short Form ◽  
Performance Status ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Sf 36

CONTEXT AND OBJECTIVE: In metastatic breast cancer cases, the currently available therapeutic approaches provide minimal improvement in survival. As such, quality of life (QOL) becomes one of the main objectives of treatment. It is not known whether current treatments derived from trials improve QOL. The aim was to evaluate changes in QOL among metastatic breast cancer patients receiving treatment derived from trials. DESIGN AND SETTING: Prospective observational QOL survey in a tertiary cancer center. METHODS: To evaluate the influence of current treatments on patients' QOL, the Medical Outcomes Study Short Form-36 (SF-36) and the Beck Depression Inventory (BDI) were applied on three occasions: before starting treatment and at the 6th and 12th weeks, to consecutive metastatic breast cancer patients over a one-year period. RESULTS: We found an improvement in QOL in the sample evaluated (n = 40), expressed by changes in the overall SF-36 score (p = 0.002) and the BDI (p = 0.004). Taken individually, the SF-36 components Pain, Social Functioning and Mental Health also improved significantly. Patients with worse initial performance status and secondary symptoms displayed greater improvement than those with better initial performance status and asymptomatic disease (p < 0.001). Patients who received more than one type of therapy showed larger gains than those given only one type (p = 0.038). CONCLUSIONS: In our environment, current metastatic breast cancer treatments can improve QOL, especially among symptomatic patients and those with low performance status.

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