Abstract P3-12-23: Breast and chest wall edema during and following radiotherapy in breast cancer patients: Prevalence, risk factors and quality of life

Abstract Purpose: The purpose of this study was to examine the impact of radiation therapy on quality of life (QOL) of breast cancer patients during and until 1 year after radiation therapy treatment. Methods and materials: Thirty-nine breast cancer patients treated with breast-conserving surgery were enrolled in a prospective study before whole breast radiation therapy (50 Gy plus a 10-Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiation therapy, and 6 weeks and 1 year after radiation therapy. The primary outcome variable was quality of life (QOL), measured by Medical Outcomes Study 36-Item Short Form Version 2 (SF-36). Risk factors potentially associated with total SF-36 scores and its physical and mental health component summary scores were also examined, including age, race, marital status, smoking history, menopausal status, endocrine treatment, cancer stage, sleep abnormalities (assessed by the Pittsburgh Sleep Quality Index), and perceived stress levels (assessed by the Perceived Stress Scale). Mixed effect modeling was used to observe QOL changes during and after radiation therapy. Results: Total SF-36 scores did not change significantly during and up to 1 year after radiation therapy compared with baseline measures. Nevertheless, increased body mass index (BMI) and increased perceived stress were predictive of reduced total SF-36 scores over time (P Z .0064, and P < .0001, respectively). In addition, increased BMI was predictive of reduced physical component summary scores of the SF-36 (P Z .0011), whereas increased perceived stress was predictive of worse mental component summary scores (P < .0001). Other proposed potential risk factors including skin toxicity from radiation therapy were not significant. Conclusions: Radiation therapy did not worsen QOL in breast cancer patients. However, preradiation therapy patient characteristics including BMI and perceived stress may be used to identify women who may experience decreased physical and mental function during and up to 1 year after radiation therapy. Copyright 2016 the Authors. Published by EJCS on behalf of Uptodate In Medicine LLC Health Sciences Publishing. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

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Depression in women breast cancer patients receiving radiation therapy: A pilot study.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e12546 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e12546-e12546

Author(s):

Fang Chen ◽

Hao Yu ◽

Caining Zhao ◽

Fan Zhang ◽

Yaqing Nong ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Risk Factors ◽

Radiation Therapy ◽

Cancer Patients ◽

Menopausal Status ◽

Adjuvant Radiation ◽

Breast Cancer Patients ◽

N Stage

e12546 Background: The purpose of this study is to study depression and its risk factors at baseline and explore the changes of depression status during the course of radiation therapy in breast patients. Methods: This is part of a prospective study of treatment toxicity and quality of life. Breast cancer patients, aged 18-year old and above requiring adjuvant radiation therapy were eligible. The primary endpoint depression was assessed by a self-addressed “depression” questionnaires according to NCI “PROMIS”. The Questionnaires were completed one day prior to, during and at the end of treatment. Patient, tumor and prior treatment factors were collected. Cancer specific symptoms were collected by treating physicians and graded according to NIH/NCI CTCAE v4.0. The variables of our interest included age, menopausal status, N-stage,pathology stage, immunohistochemisty, surgical approaches,margin,prior treatments and radiation models. Data are presented as mean (95% confidence interval) unless otherwise specified. Statistical significances were tested using generalized linear model, pearson correlation and t-text. Ps less than 0.05 were considered to be significant. Results: Between July 2019 and January 2020, a total of 185 patients enrolled and completed the PROMIS questionaires. Before RT commencement, 50/185 (27.0%) had some levels of depressive feeling including 40/185 (21.6%), 10/185 (5.4%), and 0/185 (0%) patients for “rarely” (score = 5-8), “sometimes” (score = 9-12), “often” (score = 13-16), and “always” (score 17-20), respectively. Interestingly, N stage and pathology staging group were significantly associated with the depression at baseline while age, menopausal status, immunohistochemistry, previous chemo cycles, chemo regimens and anti-Her2 taget therapy were not. At the end of RT, 51/149 (34.2%) patients had depression level changed, though the absolute lumped scores of depression did not change significantly (p = 0.437). Changes in depression during were significantly associated with menopausal status (p = 0.015) while grade 2 and above toxicities were not (p = 0.421). Conclusions: Depression feeling is not uncommon in breast patients receiving adjuvant radiation. Future study may identify patients with depression and associated risk factors so that proper intervention may be applied to improve long-term survival and quality of life in patients.

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Quality of life and related risk factors after breast reconstruction in breast cancer patients

Gland Surgery ◽

10.21037/gs-20-532 ◽

2020 ◽

Vol 9 (3) ◽

pp. 767-774

Author(s):

Xiaoqing Wang ◽

Kepeng Zhu ◽

Liang Ren ◽

Hanbing Li ◽

Shuai Lin ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Risk Factors ◽

Breast Reconstruction ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Related Risk

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NeuroCog-FX study: A multicenter cohort study on cognitive dysfunction in patients with early breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.10061 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 10061-10061 ◽

Cited By ~ 1

Author(s):

Oliver Rick ◽

Monika Reuß-Borst ◽

Timm Dauelsberg ◽

Holger Hass ◽

Volker König ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Risk Factors ◽

Cognitive Function ◽

Cancer Patients ◽

Cognitive Dysfunction ◽

Clinical Parameters ◽

Breast Cancer Patients ◽

Oncological Rehabilitation

10061 Background: Many breast cancer patients complain about cognitive dysfunction (CD) with mnestic and attentional deficits. These complaints persist even after completion of therapy in approximately one third of the patients and affects both social life and working capacity. The exact nature and genesis of CD in breast cancer patients is still not fully understood and risk factors are not yet described. Methods: To determine CD and risk factors, we used the computer-based neuropsychological test NeuroCog-FX during a three weeks oncological rehabilitation in breast cancer patients. Eight subtests addressed attention, working memory, verbal and figural memory, and language. Test duration was < 30 minutes. A cognitive deficit was diagnosed if at least one subtest was clearly below average (score < M - 1.5 SD) of the normative age group. The data on cognitive function were correlated with the level of depression (PHQ-9 test), QoL (EORTC QLQ-30) and clinical parameters (nodal status, chemo-/radiotherapy and endocrine therapy). Results: From February 2013 to December 2014 a total of 476 patients were recruited in 9 oncological rehabilitation centers in Germany. NeuroCog-FX was used to examine 439 patients. Median age was 50 years (range: 24-62 years); 93% of patients had early tumor stage (T0-T2) and 67% were node-negative. Sixty-one percent of the patients received chemotherapy while 84% of the subjects underwent radiotherapy. CD was found in 59% and a moderate to severe depression in 38% of the patients. The severity of depression was correlated with slower reaction times and reduced verbal memory performance. These two cognitive parameters were also associated with a reduced global health status and a reduced physical function score on the EORTC-QLQ30 questionnaire suggesting an impact of cognitive deficits on quality of life. Cognitive function was not associated with type of treatment or node status. Conclusions: In this large and homogeneous cohort of breast cancer patients, CD has been shown in most of the subjects using a valid test method. CD was associated with depression and reduced quality of life. Neither tumor therapy nor other clinical parameters had a significant impact on development of CD.

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The effect of psychological group intervention on emotional problems, event impact and quality of life in breast cancer patients under radiotherapy: a pilot study

Journal of Evidence-Based Psychotherapies ◽

10.24193/jebp.2017.2.8 ◽

2017 ◽

Vol 17 (2) ◽

pp. 133-146 ◽

Cited By ~ 2

Author(s):

Mihaela Iancu ◽

◽

Florina Pop ◽

Raluca Ioana Farcaș ◽

Amfiana Gherman ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Pilot Study ◽

Cancer Patients ◽

Group Intervention ◽

Emotional Problems ◽

Breast Cancer Patients

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PSYCHOLOGICAL REHABILITATION AND SCREENING OF EMOTIONAL STRESS IN CANCER PATIENTS

Problems in oncology ◽

10.37469/0507-3758-2017-63-2-316-319 ◽

2017 ◽

Vol 63 (2) ◽

pp. 316-319 ◽

Cited By ~ 2

Author(s):

Valentina Chulkova ◽

Tatyana Semiglazova ◽

Margarita Vagaytseva ◽

Andrey Karitskiy ◽

Yevgeniy Demin ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patient ◽

Cancer Patients ◽

Emotional Stress ◽

Self Esteem ◽

Breast Cancer Patients ◽

Psychological Study ◽

Psychological Assistance

Psychological rehabilitation is an integral part of rehabilitation of a cancer patient. Psychological rehabilitation is aimed at a patient adaptation in the situation of the disease and improvement his quality of life. Understanding of an oncological disease is extreme and (or) crisis situation and monitoring dynamics of the psychological statement of a patient allows using differentiated approach in the provision of professional psychological assistance. The modified scale of self-esteem level of distress (IPOS) was used for screening of mental and emotional stress of cancer patients. There were selected groups of cancer patients who were most in need of professional psychological assistance. Results of a psychological study of one of these groups - breast cancer patients - are presented.

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