Phyllodes tumor of breast, real-world data from a referral center in Mexico.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19356-e19356
Author(s):  
María Inés Contreras-Salcido ◽  
Carlos Eduardo Salazar-Mejía ◽  
Adriana González-Gutiérrez ◽  
Rolando Jacob Martinez ◽  
Jackeline Grace Lara-Campos ◽  
...  
Keyword(s):  
Radical Mastectomy ◽  
Phyllodes Tumor ◽  
Breast Disease ◽  
Breast Conserving Surgery ◽  
Real World Data ◽  
Referral Center ◽  
Phyllodes Tumors ◽  
Wide Range ◽  
Simple Mastectomy ◽  
Mixed Histology

e19356 Background: Phyllodes tumors of breast (PTB) comprise a wide range of rare fibroepithelial neoplasms representing less than 1% of all breast tumors. Studies that describe the clinical characteristics of Mexican women with PTB are scarce. Methods: We performed a retrospective analysis of all patients with newly diagnosed PTB treated at an oncology referral center in Northeast Mexico from 2013 to 2018. Results: Twenty-three women were included in the analysis. Median age at diagnosis was 51 years. Diagnosis was made by self-detection in all cases, with a median tumor size of 12.8 cm. Approximately 26% of patients had a history of benign breast disease. Regarding treatment received 39% underwent radical mastectomy whereas simple mastectomy and breast-conserving surgery were performed in 39 and 22%, respectively. PTB were classified as benign, borderline, and malignant in 17, 13, and 70% of cases, respectively. Patients with malignant PTB showed a heterologous component in 22% of cases (60% with mixed histology, 20% fibromyxosarcoma, and 20% osteosarcoma). Metastatic disease at diagnosis was documented in 3 patients. Relapse of disease was confirmed in eight patients, two of them corresponded with borderline histology and six to malignant subtype. Recurrence sites by frequency were locoregional only 38%; distant disease to the lungs only 12%; and combined metastases to lung, liver and central nervous system 50%. Regarding management of recurrence, four patients received chemotherapy, two received only radiotherapy, one was treated with radiotherapy and chemotherapy and one woman received surgical treatment with adjuvant radiotherapy. Among all patients analyzed, the median overall survival was 23.6 months. Conclusions: To our knowledge, this is one of the first studies analyzing the clinical-pathological characteristics of phyllodes tumors in the Mexican population.

scholarly journals A Giant Exulcerated Phyllodes Breast Tumor - A Case Report

2020 ◽  
Vol 21 (1) ◽  
pp. 83-86
Author(s):  
Marko Spasic ◽  
Bojan Milosevic ◽  
Slobodanka Mitrovic ◽  
Nenad Markovic ◽  
Mladen Pavlovic ◽  
...  
Keyword(s):  
Radical Mastectomy ◽  
Phyllodes Tumor ◽  
High Survival ◽  
Phyllodes Tumors ◽  
Traditional Procedure ◽  
Simple Mastectomy ◽  
Malignant Breast ◽  
The Right ◽  
Positive Outlook ◽  
Tumor Types

AbstractPhyllodes tumors of the breast can be benign, malignant, or borderline. Benign and borderline tumors are rare tumor types that have a positive outlook and high survival rate, while the risk of recurrence is typical for malignant breast tumors. Giant phyllodes tumors are larger than 10 cm in diameter and demand a serious diagnostic and treatment approach.In this study we present a case of a female patient treated for an exulcerated breast carcinoma- a giant borderline phyllodes tumor of the breast. The patient presented to the department for the right breast lump with ulcerated skin and nipple abnormalities. The core biopsy was performed and the patient was diagnosed with a benign tumor. Simple mastectomy was performed and final histopathological report revealed a borderline phyllodes tumor. Diagnosis and treatment of a giant phyllodes tumor remain a great challenge for the surgeons. Establishing the preoperative diagnosis based on histopathological findings is imperative to disease management. Surgery is the mainstay of treatment and mastectomy has been the traditional procedure; in cases where suspicious findings in the axilla are revealed, radical mastectomy is performed and the axilla is to be dissected.

Fibroepithelial Breast Tumors: Cohort Study

2020 ◽  
Vol 106 (1_suppl) ◽  
pp. 39-39
Author(s):  
Mohammed Gamil ◽  
Magda Murad ◽  
Nelly Hassan Ali el din ◽  
Ashraf Sobhy Zakaria
Keyword(s):  
Local Excision ◽  
Wide Local Excision ◽  
Radical Mastectomy ◽  
Breast Tumors ◽  
Needle Aspiration ◽  
Cancer Epidemiology ◽  
Modified Radical Mastectomy ◽  
Phyllodes Tumors ◽  
Simple Mastectomy ◽  
Study Population

Background: The frequency of mesenchymal breast tumors is very low, being represented mostly by tumors with biphasic proliferation (phyllodes tumors) and less by other types of non-epithelial tumors. Objective: To review the Management of phyllodes tumors of the breast in the NCI Cairo university during a period of 10 years (2000 till 2010). Material and Methods: Retrospective study including 99 patients who diagnosed and treated with phyllodes tumors of the breast between (2000 to 2010). Data were collected from the biostatistics and cancer epidemiology department. Results: Out of 99 patients; 51 (51.5%) were benign and 32 (32.3%) were borderline and 16 (16%) were malignant; the median age of the study population was 45.5 years (range 18–71 years).The main radiological tool of diagnosis was breast US and mammography 100%. Preoperative fine needle aspiration (FNA) was performed in 12(37.5%) cases for cytodiagnosis but true cut biopsy was done in 87 (87%) cases. Wide local excision was done in 86%, wide local excision with axillary evacuation was done in 1% only, simple mastectomy was done in 9.3% and modified radical mastectomy was done only in 3% of all cases. Conclusion: Different surgical modalities are considered the main line for management of phyllodes breast tumors. Local recurrence can be avoided with wide local excision from the first surgery. Axillary LN dissection is not a role in management of breast PT.

Malignant Phyllodes Tumor with Lipomatous Differentiation: A Unique Presentation

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S36-S36
Author(s):  
P Johal ◽  
C Sebastiano
Keyword(s):  
Phyllodes Tumor ◽  
Excisional Biopsy ◽  
Surrounding Tissue ◽  
Beta Catenin ◽  
Significant Past Medical History ◽  
Ki 67 ◽  
Complete Excision ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Wide Range

Abstract Casestudy Phyllodes tumors (PT) are uncommon biphasic fibroepithelial neoplasms that account for <1% of all breast tumors. The distinction between benign and malignant PTs is made based on a number of histologic characteristics, including an infiltrative margin, stromal overgrowth, mitotic count, hypercellularity and atypia. 30% of cases show heterologous differentiation, which mostly occurs in stromal elements. This can result in a wide range of tumor histopathology including lipomatous areas. Results We present the case of a 46-year-old female with a 3.1 cm left breast palpated mass and no significant past medical history. Ultrasound guided needle biopsy revealed multiple foci of hypercellular spindle cells with marked atypia and mitoses (ki-67: 40–60%) surrounded by focal fat necrosis. Immunohistochemical staining was negative for CK 5/6, p63, CAM 5.2, SMA, desmin, AE1/3, CD163, nuclear beta-catenin and CD34. The patient subsequently underwent a wire localization excisional biopsy. Microscopic examination revealed a biphasic hypercellular lesion with both stromal and distorted glandular elements and extensive lipomatous differentiation. Although mostly well- circumscribed, some infiltration into the surrounding tissue was identified as well as nuclear atypia and an increased mitotic rate (10 mitoses/HPF). The diagnosis of malignant phyllodes tumor with lipomatous differentiation was made based on these findings. FISH was performed and was negative for MDM2, suggesting that the lipomatous component itself was not malignant (i.e. liposarcoma) Conclusion Malignant phyllodes tumors rarely show heterologous differentiation. A literature review revealed that most lipomatous differentiation was liposarcomatous with rare cases of pure lipomatous metaplasia. Although malignant phyllodes tumor have the highest rate of metastasis relative to their benign counterparts, complete excision has resulted in a mortality rate of approximately 12%. The clinical implications of lipomatous differentiation are currently unknown. However, in these cases ensuring the lack of malignant liposarcomatous tumor growth is imperative.

scholarly journals Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Breast Care ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 291-294 ◽  
Author(s):  
Canan Kelten ◽  
Ceren Boyaci ◽  
Cem Leblebici ◽  
Kemal Behzatoglu ◽  
Didem C. Trabulus ◽  
...  
Keyword(s):  
Case Report ◽  
Bone Cyst ◽  
Clinical Breast Examination ◽  
Phyllodes Tumor ◽  
Breast Cancer Diagnosis ◽  
Left Breast ◽  
Malignant Phyllodes Tumor ◽  
Her Family ◽  
Simple Mastectomy ◽  
Clinical Breast

Background: Malignant phyllodes tumors of the breast are rare biphasic neoplasms. Only few cases related to pregnancy have been reported. Case Report: A 37-year-old woman presented with swelling and pain in her left breast as well as hyperemia on the breast skin, 4 weeks after labor. In her family history, her aunt and maternal cousin had had a breast cancer diagnosis. Clinical evaluation of the patient was consistent with a breast abscess. Therefore, abscess drainage and biopsy from the cavity wall were performed. However, the biopsy was diagnosed as malignant phyllodes tumor. An evaluation by ultrasonography showed a well-defined hypoechoic mass with many cystic spaces covering the entire breast tissue. Therefore, a simple mastectomy was performed. Microscopic examination revealed a high-grade malignant phyllodes tumor. Additionally, bone cyst-like areas in the form of sponge-like blood-filled non-endothelialized spaces were observed. Conclusions: Since the breasts become larger due to the physiological changes during pregnancy, any underlying breast lesions may be obscured. Therefore, clinical breast examination in the first visit of pregnancy is important.

Breast Cancer in Childhood

1968 ◽  
Vol 54 (5) ◽  
pp. 369-377 ◽  
Author(s):  
Umberto Veronesi ◽  
Lorenzo Zingo ◽  
Bruno Salvadori
Keyword(s):  
Breast Cancer ◽  
Surgical Procedure ◽  
Radical Mastectomy ◽  
Principal Characteristics ◽  
Simple Mastectomy ◽  
Cancer In Children

A case of breast cancer in a 8-year old girl is described, and 23 cases of breast cancer in children previously reported in the literature are analysed. The principal characteristics of breast cancer in children, unlike breast cancer in adults, seem to be a better prognosis, not depending on the surgical procedure (excision, simple mastectomy or radical mastectomy) and the frequent secretive appearance of the neoplasm, always of ductal origin.

scholarly journals A Comparison of Mammography and Ultrasonography in the Evaluation of Breast Masses in Early Stage

2018 ◽  
Vol 2 (2) ◽  
pp. 209-220
Author(s):  
Salwa Sadoon ◽  
Muhammed Naseer ◽  
Sameerah Saadoon ◽  
Hadeel Ahmed
Keyword(s):  
Early Stage ◽  
Phyllodes Tumor ◽  
Breast Disease ◽  
Breast Diseases ◽  
Prospective Clinical Study ◽  
Simple Cyst ◽  
Secondary Sexual Characteristics ◽  
Breast Examination ◽  
Sexual Characteristics ◽  
Palpable Breast

Breasts are one of the secondary sexual characteristics in females. They are the rout for of nutrition & growing of infant till 4-6 months of age. Breast diseases are one of the most common diseases in the females of any society. Multiple types of benign breast lesions like fibroadenomas, simple cyst, breast abscess, lymph nodes enlargement and different malignancies are common pathologies of the breast. Up to 30% of women suffer from benign breast disease at any time of their life and this compels them to take the treatment. The prospective clinical study was achieved for 283 women ( age was ranged between 20 60 years) had palpable breast lesion referred by their managing surgeons to the radiological department at Azadi Teaching Hospital, for a period of 8 months (from January 2018 to August of the same year). The study depended firstly in all women on clinical examination/self-breast examination. Results:- 283 patients were included in this study with age between 20 _ 60 ys, most of the patients were diagnosed as fibroadenoma which is most common around 54.9% of the total cases studied, Fibrocystic diseases (Duct ectasia, cysts, and galactocele ) 19.3 %.Followed by infection as mastitis 15.4%, and phyllodes tumor less than 1% approximately and finally carcinoma 9.5%.

scholarly journals Towards motivation-based adaptation of difficulty in e-learning programs

2012 ◽  
Vol 28 (7) ◽  
Author(s):  
Anke Endler ◽  
Gunter Daniel Rey ◽  
Martin V. Butz
Keyword(s):  
Adaptation Strategies ◽  
Future Research ◽  
Proximal Development ◽  
Real World Data ◽  
Learning Classifier System ◽  
Wide Range ◽  
Learning Programs ◽  
Reported Study ◽  
E Learning ◽  
User Motivation

<span>The objective of this study was to investigate if an e-learning environment may use measurements of the user's current motivation to adapt the level of task difficulty for more effective learning. In the reported study, motivation-based adaptation was applied randomly to collect a wide range of data for different adaptations in a variety of motivational states. This data was then utilised to extract rules for an adequate motivation-based adaptation to maximise expected learning success. A learning classifier system was used for the data analysis, generating rules for suitable and unsuitable adaptations based on current user motivation data. We extracted a set of twelve rules which suggest particular adaptation strategies based on real-world data. These rules could generally be embedded into existing psychological theories, namely the Zone of Proximal Development and the Yerkes-Dodson Law. In future research, we intend to evaluate these rules on further studies and develop concrete sets of adaptation strategies based on user motivation measurements.</span>

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