Characteristics, management and outcomes of patients with hepatocarcinoma in a low-income country.

e16166 Background: Worldwide, every year, there are nearly 905,000 patients diagnosed with liver cancer; it is the sixth most common malignancy and the third most lethal malignancy. Almost three quarters of new patients live in areas with low and medium-income country. Guatemala has the highest mortality and incidence of liver cancer. Objectives: Describe the clinical characteristics, main risk factors, treatment and outcomes of patients with hepatocarcinoma (HCC) in Guatemala. Methods: A retrospective review was performed among patients with HCC from January 2002 to December 2019 in the Instituto Guatemalteco de Seguridad Social (IGSS). Kaplan Meier curves, Cox regression and log-rank test were used to calculate overall survival (OS) and mortality. Results: 140 patients with HCC were analyzed, 114 women and 26 men with a median age of 60 years (20 - 99), 102 patients (73%) have history of excessive alcohol consumption and 11 (8%) has history of chronic hepatitis B or C virus infection. All of the patients have liver cirrhosis, Child-Pugh A 100 patients (71%), B 34 (24%) and C 6 (5%). 10 patients (7%) have HCC BCLC A, 0 (0%) BCLC B, 121 (81%) BCLC C and 9 (6%) BCLC D. All patients with HCC BCLC A received surgical treatment with a median OS of 123 months (95% CI 89 - 156 p < 0.001). 122 patients (89%) received target therapy with Sorafenib with a median OS of 17 months (95% CI 12 - 21 p < 0.001) and 8 patients (6%) underwent to chemoembolization with a median OS of 32 months (95% CI 12 - 52 p < 0.001). At this time, 111 patients (79%) died from the disease, 11 (8%) are alive with the disease and 8 (6%) are alive without disease. Conclusions: The most frequent risk factor for HCC is the excessive alcohol consumption, survival of patients with HCC are associated with treatment at the beginning of the disease.

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Alcoholic Cirrhosis with Zinc and Copper Co-Deficiency

Case Reports in Clinical Nutrition ◽

10.1159/000498983 ◽

2019 ◽

Vol 2 (1-3) ◽

pp. 8-15

Author(s):

Chanita Unhapipatpong ◽

Daruneewan Warodomwichit ◽

Kumutnart Chanprapaph

Keyword(s):

Alcohol Consumption ◽

Zinc Deficiency ◽

Copper Deficiency ◽

Zinc Supplementation ◽

Alcoholic Cirrhosis ◽

Oral Antibiotics ◽

Excessive Alcohol Consumption ◽

History Of ◽

Excessive Alcohol

A 54-year-old Thai female with known alcoholic cirrhosis presented with chronic scaly eczematous patches and plaque for over 1 month. Initially, she was treated with oral antibiotics, but the lesions did not improve. The dermatologic examination and history of alcoholic cirrhosis were compatible with zinc deficiency. Moreover, copper deficiency was found together with zinc deficiency. Excessive alcohol consumption can cause zinc and copper co-deficiency. To avoid aggravated copper deficiency after zinc supplementation, copper and zinc were supplemented together in appropriate proportions. On the 2-week follow-up examination, her clinical outcome improved.

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Risk factors and clinical features of recurrent stroke in the Tyva Republic

Kazan medical journal ◽

10.17816/kmj2063 ◽

2014 ◽

Vol 95 (2) ◽

pp. 199-202

Author(s):

Kh D Mongush ◽

A B Ondar ◽

R Ch Chylbak-ool ◽

M B Balchir ◽

Ch O Mongush

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Consumption ◽

Arterial Hypertension ◽

Recurrent Stroke ◽

Excessive Alcohol Consumption ◽

Stroke Group ◽

History Of ◽

Excessive Alcohol ◽

Male Patients

Aim. To determine risk factors and clinical features of the recurrent stroke. Methods. A prospective 3-year cohort study was conducted including 120 patients with stroke admitted to the neurological department of the Republican Hospital №1 of Kyzyl at 2010-2012, 60 of whom had recurrent stroke (group 1), and 60 had primary stroke (group 2). Results. Recurrent stroke was by 16.66% more common in men. The mean age of males having recurrent stroke was younger compared to females (р 0.05). Patients with family history of arterial hypertension in closest relatives were significantly more prevalent among those with recurrent stroke (70 versus 35%, p 0.05). The rate of excessive alcohol consumption was also significantly higher in patients with recurrent stroke (18.33 versus 6.67%, p 0.05). Mortality associated with the recurrent stroke was higher in males of all age groups, difference was statistically significant in male patients over 70 years of age (p 0.05). Combined first 28-day mortality was 26.67% (32 cases), and was higher in patients with primary stroke (p 0.05). Only 21.67% of patients took antihypertensives regularly prior to the primary stroke, among patients with recurrent stroke this share reached 70%. Antiplatelet drugs were taken by 5% of patients prior to the primary stroke, in patients who suffered the stroke the share was higher and reached 53.33%. Conclusion. Family history of arterial hypertension was the most important risk factor for recurrent stroke. Male patients had higher risks of recurrent stroke and fatal outcome, which may be associated with lower drug compliance (including antiplatelet drugs and anticoagulants, antihypertensives) and higher exposure to other risk factors (smoking, excessive alcohol consumption).

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To the problem of excessive alcohol consumption in Russian families

Moscow State University Bulletin Series 18 Sociology and Political Science ◽

10.24290/1029-3736-2020-26-4-142-160 ◽

2020 ◽

Vol 26 (4) ◽

pp. 142-160

Author(s):

E. N. Novoselova

Keyword(s):

Alcohol Consumption ◽

Family Members ◽

Alcoholic Beverages ◽

World Health ◽

Federal State ◽

Excessive Alcohol Consumption ◽

Working Age ◽

History Of ◽

Excessive Alcohol ◽

Health Organization

The article is devoted to the analysis of alcoholism in Russian families. The author gives a brief excurse into the history of alcohol consumption, dispels the myth that the Russian people never controlled consumption of alcoholic beverages. The work, relying on the latest statistics, demonstrated that despite the emerging positive trends in this area, the level of alcohol consumption (especially strong alcohol) in Russia is still very high and significantly exceeds the conditionally safe norm indicated by the WHO experts. It negatively affects the life expectancy of the Russian population, especially among men of working age. However, if previously alcoholism was predominantly masculine, today this type of addiction is becoming gender-neutral and women drink on a par with men, which will inevitably lead to an increase in mortality from alcohol-related causes among them.Particular attention is paid to the problems of families facing the problem of alcoholism among one or several of their members. It is emphasized that children are the most vulnerable in this situation because of their dependence on adults — they are not able to change the situation and are forced to live in constant conflict, stress and ill-treatment. The author notes that the violence to which not only children, but also other family members are subjected to in alcoholic families, is far from rare and extremely dangerous.The paper addresses the issue of the influence of alcoholism of adult family members on children's health. Children of dependent parents are often born sick and lag behind in physical and mental development. This is further aggravated by upbringing in an atmosphere of alcoholism, which leads to the fact that the younger generation perceives excessive alcohol consumption as the norm, adopts the habits of parents and also become dependent. Children of drinking parents also experience many complexities of a personal and interpersonal nature and are prone to auto-aggressive behavior.In conclusion, the author addresses the problem of social orphanhood arising from alcohol abuse by parents, as well as its consequences.The empirical part of the work is based on data from the World Health Organization, the Federal State Statistics Service, the Public Opinion Foundation and the All-Russian Center for the Study of Public Opinion.The article will be of interest to specialists in the field of sociology of family and health, prevention of addictive behavior, rehabilitation of people with addictions, and students of relevant specialties.

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"Self-medication": Does Social Anxiety Promote Excessive Alcohol Consumption in a Non-clinical Population?

PsycEXTRA Dataset ◽

10.1037/e413812005-163 ◽

2002 ◽

Author(s):

E. Y. Strahan

Keyword(s):

Social Anxiety ◽

Alcohol Consumption ◽

Clinical Population ◽

Self Medication ◽

Excessive Alcohol Consumption ◽

Excessive Alcohol

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Does Excessive Alcohol Consumption Increase Economic Cost? An Investigation from Thailand

Systematic Reviews in Pharmacy ◽

10.31838/srp.2020.4.15 ◽

2020 ◽

Vol 11 (04) ◽

Keyword(s):

Alcohol Consumption ◽

Economic Cost ◽

Excessive Alcohol Consumption ◽

Excessive Alcohol

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Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Medicines ◽

10.3390/medicines8070039 ◽

2021 ◽

Vol 8 (7) ◽

pp. 39

Author(s):

Akihiko Shibamoto ◽

Tadashi Namisaki ◽

Junya Suzuki ◽

Takahiro Kubo ◽

Satoshi Iwai ◽

...

Keyword(s):

Alcohol Consumption ◽

Biological Markers ◽

Prediction Accuracy ◽

Total Bilirubin ◽

Alcoholic Cirrhosis ◽

Serum Total Bilirubin ◽

Excessive Alcohol Consumption ◽

Significant Difference ◽

Carbohydrate Deficient Transferrin ◽

Excessive Alcohol

: Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

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Methods for Estimating Avoidable Costs of Excessive Alcohol Consumption

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094964 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4964

Author(s):

Beata Gavurova ◽

Miriama Tarhanicova

Keyword(s):

Czech Republic ◽

Alcohol Consumption ◽

Data Availability ◽

Excessive Alcohol Consumption ◽

Public Authorities ◽

The Czech Republic ◽

Cost Of Disease ◽

Lost Productivity ◽

Excessive Alcohol ◽

The Cost

Background: Alcohol is a risk factor with serious consequences for society and individuals. This study aims to present methods and approaches that might be used to estimate the costs related to excessive alcohol consumption. It emphasizes the need for general methods and approaches that are easily applicable, because the level of digitalization and data availability vary across regions. The lack of data makes many methods inapplicable and useless. The ease of applicability will help to make cost-of-illness studies and their results comparable globally. Methods: This study is based on data from the Czech Republic in 2017. Drinking alcohol results in costs of healthcare, social care, law enforcement, and administrative costs of public authorities. To quantify the cost of drinking in the Czech Republic, the top-down approach, bottom-up approach, human capital approach and attributable fractions were used. Results: In 2017, the cost related to alcohol was estimated at 0.66% of the national GDP. Lost productivity represented 54.45% of total cost related to alcohol. All cost related to alcohol is considered to be avoidable. Conclusions: The methods and approaches applied to estimate the cost of disease or any other health issue should be generalized regarding the availability of data and specifics of provided services to people who are addicted or have any kind of disability.

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