Feasibility of ovarian preservation as a stage in correcting the quality of life in young patients after gynecologic surgeries.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17560-e17560
Author(s):  
Natalia V. Chernikova ◽  
Ekaterina V. Verenikina ◽  
Yuriy A. Poryvaev ◽  
Tatiana Yu. Myagkova ◽  
Anna P. Menshenina
Keyword(s):  
Quality Of Life ◽  
Blood Flow ◽  
Hormone Replacement ◽  
Young Patients ◽  
Lateral Wall ◽  
Regular Growth ◽  
Doppler Techniques ◽  
Almost All

e17560 Background: The purpose of the study was to analyze the structure and activity of the blood flow in the preserved ovaries after gynecologic surgeries. Methods: We monitored 50 patients (mean age 35.8±0.5 years) using sonography after ovary-sparing hysterectomy for benign, precancerous and preinvasive malignant uterine diseases. For revascularization, the preserved ovaries were attached to the lateral wall of the small pelvis or to the base of round ligaments of the uterus. Results: Ovarian hypertrophy was recorded in 3 women during the first year of the follow-up; the ovaries returned to the initial size without correction by 24 months. By the third year of observation, 94% of women had normal gonadal sizes, and only 2 women had ovarian hypoplasia. During the entire observation period (3 years), in 91% of cases, we could visualize the regular maturation of follicles in the preserved ovaries, which indicated the preservation of ovulatory function. The use of Doppler techniques during 24 months of the follow-up demonstrated that the blood circulation in the attached ovaries after hysterectomy was decreased on the average by 20.3%, compared to the intact ovaries. Conclusions: After the critical period of hysterectomy, the blood flow in the ovaries in almost all patients remains sufficient during the first 2-3 years, stimulating the regular growth of follicles and maintaining the gonadal activity. The quality of life of the operated patients during the first three years of follow-up remains optimal without additional correction with hormone replacement therapy.

scholarly journals Evaluation of effectiveness of complex treatment of chronic generalized periodontitis using original splinting design

2021 ◽  
Vol 38 (6) ◽  
pp. 83-93
Author(s):  
N. B. Astashina ◽  
E. P. Rogozhnikova ◽  
A. S. Arutyunov ◽  
N. N. Malginov ◽  
S. V. Kazakov
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Negative Impact ◽  
Young Patients ◽  
Pathological Process ◽  
Main Group ◽  
Complex Treatment ◽  
Periodontal Tissues

Relevance. The relevance of the study is dictated by the high prevalence of periodontal disease among young people and by the need to search for new approaches to periodontitis treatment in order to increase the effectiveness of treatment at early stages of pathological process. Objective. To evaluate the effectiveness of complex treatment of chronic generalized periodontitis (CGP) of mild severity using a removable splinting construction made according to the author's technique. Materials and methods. At the orthopedic stage of the complex treatment of mild CGP, splinting constructions were used for 47 young patients: in the main group (n = 16) the authors treatment and preventive splint, in the first comparison group (n = 15) a removable metal splint, in the second comparison group (n = 16) a fixed adhesive fiber splint. Periodontal hemodynamics was assessed using ultrasound Doppler analysis 1, 6 and 12 months after the therapeutic measures and tooth immobilization. To identify the possible negative impact of the treatment on the quality of life (QOL) in patients with splint constructions, we used the OHIP-14-Ru questionnaire; the follow-up period was 1.3, 6, and 12 months. Results. Dental immobilization contributed to the improvement of blood flow in the periodontal tissues in the short and long term follow-up, so after 12 months: Vam in the main group increased by 39,8 % and amounted to 0,397 0,004 cm / s, in patients of the comparison groups Vam was 0,329 0,006 cm / s and 0,335 0,003 cm / s, respectively, that is 15,4 % and 18,4 % higher compared with the figures before treatment. The quality of life index for patients using splinting constructions made according to the author's technique, by the OHIP-14-Ru questionnaire was assessed as good 1 year after (3.46 0.59). Conclusions. The use of the proposed original orthopedic design in a complex plan for mild periodontitis treatment helps to improve regional blood circulation and stabilize the pathological process.

scholarly journals QOL-06. QUALITY OF LIFE IN MEDULLOBLASTOMA SURVIVORS IN WESTERN MEXICO

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii432-iii432
Author(s):  
Regina M Navarro-Martin del Campo ◽  
Jorge L Macias-Toscano ◽  
Erika Toral-Casillas ◽  
Fernando Sánchez-Zubieta ◽  
Ana L Orozco-Alvarado
Keyword(s):  
Quality Of Life ◽  
Functional State ◽  
Clinical Data ◽  
Negative Impact ◽  
Hormone Replacement ◽  
Academic Development ◽  
Western Mexico

Abstract BACKGROUND Treatment of children with medulloblastoma (MB) can lead survivors to lidiate with long term sequelae and affect their quality of life (QoL). This study evaluates QoL in long term MB survivors. DESIGN/ METHODS Clinical files of MB survivors from 1997 to 2016 were retrospectively analyzed. QoL was defined by Schipper Criteria in a five dimensional evaluation: clinical data, physic effects of treatment, academic develop, functional state and self welfare report. RESULTS Clinical data: Twenty eight survivors were identified, mean age at review was 18 years, median follow up was 106 months. Functional state: Last visit Karfnosky/lansky were 90 to 80% in 25% of patients. Physic effects of treatment: Cerebellar Mutism or ataxia were present in 25% of cases. Two patients required external dispositives. Audiometry detected an auditive tonal decrease in 25% of cases. An endocrine disfunction was present in 46% of cases, 32% required hormone replacement and 28% having short size. Renal damage without dialysis was detected in 7% and 10% had a transient tubulopaty. One case had bilateral amaurosis and 14% uses glasses. Three patients had a life partner. One female has offspring and two males had azoospermia. Academic development: While 90% attends to school, 35.7% complained of learning difficulties and 18% needed special education. Self welfare report: Difficulties in social environment were described in 21% and 14% still feeling sick during years. CONCLUSIONS Survivors of MB had adverse physical effects, followed by academic development, functional state and self welfare report and all this has a negative impact in their QoL.

scholarly journals An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Alessandro Antonelli ◽  
Fiorella Averta ◽  
Federica Diodati ◽  
Danila Muraca ◽  
Ylenia Brancaccio ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Plasma Cell ◽  
Laboratory Tests ◽  
Young Patients ◽  
Upper Aerodigestive Tract ◽  
Favorable Prognosis ◽  
Oral Pain ◽  
Uncommon Case

Plasma cell mucositis (PCM) is an unusual plasma cell proliferative disorder of the upper aerodigestive tract. It is a rare disease, and its etiology is not yet known with variable clinical features. Symptoms include dysphagia, oral pain, and swelling. We described a case of PCM involving the tongue of a 14-year-old man. In the first place, several diagnostic hypotheses were proposed, most of them discarded for incompatibility with blood and laboratory tests. This disease rarely manifests itself on the tongue, especially in young patients with no comorbidities. The management of PCM is mainly aimed at reducing the symptoms, and in our report, the treatment involved the use of systemic prednisone with an improvement of the quality of life. At 1-year follow-up, there was no recurrence of the disease. Many therapeutic treatments are able to stabilize but not able to induce a complete remission. PCM is considered an uncommon benign disorder with a favorable prognosis and should be considered in the differential diagnosis with other inflammatory or neoplastic conditions.

scholarly journals Evaluation of the quality of life dynamics by methods of survival analysis in patients with hip joint ar-throplasty

2021 ◽  
Vol 27 (5) ◽  
pp. 527-531
Author(s):  
A.N. Tkachenko ◽  
◽  
A.A. Korneenkov ◽  
Yu.L. Dorofeev ◽  
D.Sh. Mansurov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Survival Analysis ◽  
Hip Joint ◽  
Hip Arthroplasty ◽  
Postoperative Period ◽  
Young Patients ◽  
Long Term Results

Abstract. Introduction The study deals with the approaches to the analysis of the dynamics in the course of a long-term postoperative period in patients who underwent hip arthroplasty. Aim To feature the variants in the course of a long-term postoperative period in patients who underwent arthroplasty of the hip joint. Materials and methods 806 patients (age range, 9 to 88 years) suffering from osteoarthritis underwent primary total hip arthroplasty (THA). Statistical analysis was carried out using the R programming language, freely available at https://cran.r-project.org. The probability of maintaining satisfactory quality of life (QoL) at a certain time of observation t (year of observation) was assessed with the Kaplan-Meier method. To compare the likelihood of maintaining a satisfactory QoL level throughout the observation period in several groups (for example, patients of different sexes), the logrank test was used. Results By year 6 of follow-up, the following tendency emerges regarding the age of the patients. The indicators are the best in young patients (up to 44 years old), where the probability of maintaining a satisfactory QoL evaluation was 0.92 (0.84; 0.96). A somewhat lower values were observed in the patients of the middle age group (from 45 to 64 years old) – 0.87 (0.78; 0.92). Excellent and good QoL was found in patients aged 65 and older, 0.83 (0.76; 0.88). Discussion Survival analysis methods have been used for the first time in traumatology and orthopedics. Previous researchers assessed the long-term results of the quality of specialized traumatological and orthopedic care without considering censored observations. Thus, the coverage of the investigated clinical observations averaged 80-85%. Information about 10-15% of cases was excluded from the studies. The proposed method of analysis provides information about all patients. Conclusions Five years following THA, an excellent and good quality of life could be expected in 85 % of patients. Satisfactory and poor levels are observed in 15 % of patients. At 5-year follow-up after THA, the quality of life is worse in older female groups with severe concomitant pathology; however, there are no statistically significant differences. This is a tendency, and requires further study.

scholarly journals 752 Acute coronary syndrome in young patients: long-term follow-up and quality of life assessment

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Francesca Parisi ◽  
Claudio Nicolò ◽  
Marco Franzino ◽  
Giualia De Santis ◽  
Lorenzo Pistelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Events ◽  
Obstructive Coronary Artery Disease ◽  
Young Patients ◽  
Coronary Syndrome ◽  
Long Term Follow Up ◽  
Artery Disease

Abstract Aims Early onset acute coronary syndrome (ACS) is associated with a more aggressive evolution and its consequences can be devastating to the quality of life (QOL), affecting the patient’s psychology, ability to work, and the socioeconomic burden. In the last decade, the incidence of ACS in young patients (≤45 years old) is increased but unfortunately, little is known about long-term follow-up and impact on quality of life. The aim of this study was to analyse the clinical evolutions and the QOL in this specific group of patients. Methods and results We included 91 consecutive young patients (≤45 years at the time of presentation) with ACS referred from October 2013 until March 2021 to our clinic. All enrolled patients underwent angiography. We analysed the clinical presentation, echocardiography, and therapy at the time of discharge. Furthermore, patients underwent telephone follow-up after 40 months: new hospitalizations, cardiovascular events, bleeding, and relevant changes in medical therapy were investigated. In addition, patients were also invited to participate to a survey to investigate QOL, sexual, and socioeconomic changes after ACS. QOL was explored through the EQ-5D scale using the time trade-off (TTO) and visual analogue scale (VAS) technique based on European values. Mean age was 40.6 ± 3.6 years and 17.6% were women. Most patients had obstructive coronary artery disease at angiography (90.1%) and 85.7% underwent PCI. At a median follow-up of 40 months, major adverse cardiovascular events (MACE) a composite of death, myocardial infarction, stroke and definite stent thrombosis, occurred in 12% of patients (Figure 1). Patient reported bleeding occurred in 29.8%, while bleeding requiring hospitalization in 3.6%. Univariate predictors of MACE were previous stroke, Killip class at presentation, current drug use, left ventricle ejection fraction, wall motion score index (WMSI), and haemoglobin at admission. Young patients showed reduced levels of QOL (TTO: 0.85 ± 0.17—VAD: 0.79 ± 0.17), with higher levels among individuals without obstructive coronary artery disease (Figure 2). Predictors of lower quality of life were WMSI, left anterior descending (LAD) stenting, left ventricular aneurysm and ventricular thrombus (Figure 3). After 12 months from the index event, 31.5% of patients were still on dual antiplatelet therapy, and the mean number of medications was 4.65 ± 2.3. Conclusions In conclusion, young patients have a high residual risk of ischaemic and bleeding events and impaired QOL. Optimization of medical therapy and better patient information is of upmost importance to mitigate residual risk of adverse events.

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