Clinical Trials for Herbal Extracts

2004 ◽  
Author(s):  
Adrian Dobs ◽  
Bimal Ashar
Keyword(s):  
Clinical Trials ◽  
Herbal Extracts

Phytotherapic Drugs For Covid19 Treatment: A Scoping Review

2021 ◽  
Vol 27 ◽  
Author(s):  
Meenakshi Singh ◽  
Darshini Trivedi ◽  
Reecha Mohapatra ◽  
Trisha Bagchi ◽  
Chandra Sai Potla Durthi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Antiviral Activity ◽  
Human Health ◽  
Bioactive Compounds ◽  
Well Being ◽  
Bioactive Metabolites ◽  
Herbal Extracts ◽  
Plant Metabolites ◽  
Health Crisis

Background: The rapid eruption of Coronavirus at the end of 2019 has caused global health crisis and significant loss to the economy and social well-being. This created a massive shortage of advanced health facilities with inadequate medicinal supply, further deteriorating human health conditions. On the basis of adverse effects of the ongoing pandemic, this review is proposed to evaluate the antiviral efficacy of plant-based therapeutics against SARS-CoV-2 (commonly called COVID19) infection. It highlights the possible action of the mechanism of phytotherapeutic drugs against coronavirus inhibition, further validated by clinical trials on herbal formulas. Though the experimental studies on COVID19 treatment are limited, the undesirable side effects of herbal drugs and unidentified compounds cannot be ignored. Objective: We have made an effort to study the prospective plant-derived bioactive entities and their effectiveness in the treatment of COVID19 and emphasize safety and regulatory concerns of phytomedicines. Methods: The methodology involves the relevant studies on COVID19 treatment based on herbal extracts and the purified bioactive metabolites. The e-literature survey is done by downloading research articles available on PubMed (National library of medicine), Elsevier, and Google scholar search engines. The keywords used are plant metabolites, natural bioactive, phytotherapeutic drugs, clinical trials, SARS-CoV-2, Coronavirus inhibitors and herbal extracts. Results: The review pays particular attention to the etiological study of the COVID19 virus and its inhibition using medicinal plant metabolites as immunomodulatory agents. The application of valuable bioactive like phenolic compounds, saponins, alkaloids, tannins, flavonoids and terpenoids in preparing herbal formula/drug. The drug resistance of bioactive compounds and their side effects on human health were discussed for effective phytomedicine. Thus, emphasizing the perspectives of phytotherapeutic drugs as a safe remedy to boost immunomodulatory functions and antiviral activity against COVID19. Conclusion: Altogether, the review presents the action mechanism of plant extracts rich in bioactive compounds and depicted potential antiviral activity against SARS-CoV-2. These plant bioactive compounds can serve as lead molecules to develop phytomedicine, ensuring all safety regulations in the clinical trials to treat or prevent COVID19 viral infections.

scholarly journals Obesity Phytotherapy

2015 ◽  
Vol 21 (3) ◽  
pp. 228-234 ◽  
Author(s):  
Mahmoud Bahmani ◽  
Zohreh Eftekhari ◽  
Kourosh Saki ◽  
Ezatollah Fazeli-Moghadam ◽  
Mahyar Jelodari ◽  
...  
Keyword(s):  
Weight Loss ◽  
Clinical Trials ◽  
Medicinal Plants ◽  
Guar Gum ◽  
Modern Medicine ◽  
Citrus Aurantium ◽  
Herbal Extracts ◽  
Synthetic Drugs ◽  
Herbal Medications ◽  
Induce Weight Loss

Obesity is an important disorders due to which 25 million deaths occur annually worldwide. Synthetic drugs for weight loss have low efficacy and high side effects. Apart from synthetic drugs in modern medicine, various other methods including the use of herbal medications are used to induce weight loss. Cambodia hoodia, green tea, Citrus aurantium, white beans, fenugreek, caffeine, ephedrine, capsaicin, yohimbine, chitosan, fitostreols, and guar gum have been studied in clinical trials and their effects have been confirmed. It seems necessary to study more to determine the effectiveness and safety of medicinal plants and herbal extracts as well as pharmaceutically active ingredients that may have the property of weight loss. In this article, we aimed to review recent knowledge about medicinal plants that are recommended for weight loss.

A recent update on the clinical trials and effectiveness of drugs used in COVID-19, MERS and SARS Coronaviruses.

2021 ◽  
Vol 19 ◽  
Author(s):  
Seyed Sajad Hosseini Balef ◽  
Zohreh Karimi ◽  
Ala Azari ◽  
Seyed Sadeq Sadraie ◽  
Parisa Hasanjani ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Drug Treatment ◽  
Treatment Strategy ◽  
Death Rate ◽  
Treatment Strategies ◽  
Herbal Extracts ◽  
The World ◽  
Effective Drugs ◽  
Comprehensive Study

Background: Coronaviruses including COVID-19, MERS and SARS have affected millions of people around the world since its emerge. Still, there is not a certain drug treatment strategy for Coronaviruses. Objective: This review aims at a compilation of a comprehensive study on literature reporting the treatment strategies and regimens used for COVID-19, MERS and SARS with an emphasis on the clinical trials and experimentations. Results: According to the literature, the most effective drugs reported so far for treatment strategies include: lopinavir/ritonavir, favipiravir, ribavirin, oseltamivir, remdesivir, hydroxychloroquine, herbal extracts, monoclonal antibodies and anticytokine agents. Some combinations of drugs have been very effective to reduce the death rate, hospitalization stay and to prevent the progress of the disease to the later critical and severe stages. Conclusions: However, a combination of drugs and regimens have been useful and saved millions of patient’s lives but the clinical data reviewed in this essay indicate that the current drugs do not make an impervious barrier against coronavirus infections and cannot protect or treat patients completely. Therefore, there is a much demand towards discovery and introduction of new antiviral drugs.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

Patients' satisfaction in clinical trials

2000 ◽  
Vol 248 (6) ◽  
pp. 441-442 ◽  
Author(s):  
L. Terenius
Keyword(s):  
Clinical Trials ◽  
Patients Satisfaction

Rome I versus Rome II; Overlap in patients enrolled in tegaserod phase III clinical trials for irritable bowel syndrome (IBS)

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
B NAULT ◽  
S SUE ◽  
J HEGGLAND ◽  
S GOHARI ◽  
G LIGOZIO ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Irritable Bowel Syndrome ◽  
Phase Iii ◽  
Phase Iii Clinical Trials ◽  
Irritable Bowel ◽  
Rome I

Clinical trials screening: An opportunity to increase medical care access

2001 ◽  
Vol 120 (5) ◽  
pp. A410-A410
Author(s):  
T KOVASC ◽  
R ALTMAN ◽  
R JUTABHA ◽  
G OHNING
Keyword(s):  
Clinical Trials ◽  
Medical Care ◽  
Care Access
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