This paper aims to examine the cyclic behavior of panels in steel moment frame subjected to bidirectional and unidirectional loading and to demonstrate the differences of panel behavior under two loading modes. The specimens were composed of wide-flange beams and square tube columns, and the panel zones were designed to yield before columns and beams. Experimental results showed that specimens subjected to bidirectional loading suffered severe damage, caused by the weld fracture at the corner of panel-to-diaphragm weld, and failed at 0.06 rad and 0.04 rad story drift for specimens with panel aspect ratio of 1.4 and 2.0, respectively. Specimens subjected to unidirectional loading developed a story drift of 0.06 rad without strength reduction. The panels contributed about 60%-80% story drift and dissipated approximately 80% of total input energy. Panels with higher aspect ratio showed smaller plastic shear strength because of the effect of flexural yielding in panels. Moreover, the beams were found to present plastic moments 20%-50% lower than theoretical values, which was attributed to the small panel-to-beam strength ratio.