Among the methods used for the treatment of cancer, chemotherapy is widely used, and it is
by far one of the most unpleasant procedures given to a patient because of its severe side effects; while
being necessary. One of the major problems in cancer chemotherapy is the limited selectivity of most
of the drugs in current clinical use. Following administration, the active agent is distributed over the
entire body and reaches not only the target cells or tissues but also interacts with healthy cells. In an
attempt to overcome the side effects of anticancer drugs, the modification of the anticancer bioactive
compounds has been a topic of active research for years. Numerous delivery systems such as drugcontaining
liposomes, microencapsulation, nanoparticles, and water-soluble polymers have been used
for the delivery of bioactive compounds to the site of action. Water-soluble polymeric conjugates and
co-conjugates have remained the most outstanding delivery technique. This review will discuss the development
of polymeric conjugates and co-conjugates of ferrocene in cancer research.
New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds