Neanderthals of Western Europe lived across distinct ecogeographic zones from Marine Iso-tope Stage 7 to 3. Differences in dental morphology from seven Western European sites are compared in terms of ecogeography and chronology.Neanderthals (n = 12) along a north-south gradient were examined. These included the Meuse River Basin of Belgium (Engis 2 and Scladina 1-4A ), Southwest France (Pech de l'Azé 1 and Roc de Marsal), the Pyrenees (Malarnaud and Montmaurin), and the Mediterranean (Hortus). Montmaurin is the oldest, followed by Scladina 1-4A and Malarnaud, whereas the others are younger.Dental casts were prepared from Neanderthal permanent and deciduous dentition. These were de-scribed and scored, according to the ASUDAS. Comparisons of dental traits with respect to ecogeo-graphic regions and chronological categories were constructed.Unusual dental features observed include the anterior fovea, entoconulid, metaconulid, and Cara-belli’s cusp. Dental traits that distinguish ecogeographic regions are the expression of the M1 hypocone and metaconule, whereas the hypoconulid and Carabelli’s cusp separate chronological categories. Dif-ferences are present for the entoconulid and metaconulid in both comparisons.Neither chronology nor ecogeography fully explains the results. Similarities in dental traits exist between Roc de Marsal, Pech de l’Azé 1 and Engis 2, and secondarily within the Hortus assemblage.