Mechanics of Tissue/Lymphatic Transport

Biomechanics ◽  
2014 ◽  
pp. 15-1-15-18
Author(s):  
Alan Hargens
Keyword(s):  
Lymphatic Transport

Sentinel lymph node diagnostic in prostate carcinoma: Part II: Biokinetics and dosimetry of 99mTc-Nanocolloid after intraprostatic injection

2002 ◽  
Vol 41 (02) ◽  
pp. 102-107 ◽  
Author(s):  
J. Kopp ◽  
H. Vogt ◽  
F. Wawroschek ◽  
S. Gröber ◽  
R. Dorn ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Urinary Bladder ◽  
Lymph Nodes ◽  
Effective Dose ◽  
Residual Activity ◽  
Tracer Uptake ◽  
Lymphatic Transport ◽  
Radionuclide Distribution ◽  
Radioactivity Uptake

Summary Aim: To visualise the sentinel lymph nodes (SLNs) of the prostate we injected the radiotracer into the parenchyma of the prostate. The activity was deposited in liver, spleen, bone marrow, urinary bladder and regional lymphatic system. The aim of this work is to determine biokinetical data and to estimate radiation doses to the patient. Methods: The patients with prostate cancer received a sonographically controlled, transrectal administration of 99mTc-Nanocoll®, injected directly into both prostate lobes. In 10 randomly selected patients radionuclide distribution and its time course was determined via regions of interest (ROIs) over prostate, urinary bladder, liver, spleen and the lymph nodes. The uptake in the SLNs was estimated from gamma probe measurements at the surgically removed nodes. To compare tumour positive with tumour free lymph nodes according to SLN-uptake and SLNlocalisation we evaluated 108 lymph nodes out of 24 patients with tumour positive SLN. For calculating the effective dose according to ICRP 60 of the patients we used the MIRD-method and the Mirdose 3.1 software. Results: The average uptake of separate organs was: bladder content 24%, liver 25.5%, spleen 2%, sum of SLN 0.5%. An average of 9% of the applied activity remained in the prostate. The residual activity was mainly accumulated in bone marrow and blood. Occasionally a weak activity enrichment in intestinal tract and kidneys could be recognized. The effective dose to the patient was estimated to 7.6 μSv/MBq. The radioactivity uptake of the SLN varied in several orders of magnitude between 0.006% and 0.6%. The probability of SLN-metastasis was found to be independent from tracer uptake in the lymph node. The radioactivity uptake of the SLNs in distinct lymph node regions showed no significant differences. Conclusion: The radiotracer is transferred out of the prostate via blood flow, by direct transfer via the urethra into the bladder and by lymphatic transport. Injecting a total activity of 200 MBq leads to a mean effective dose of 1.5 mSv. It is not recommended to use the tracer uptake in lymph nodes as the only criterion to characterize SLNs.

scholarly journals Absorption and lymphatic transport of cholesterol in the rat

1968 ◽  
Vol 9 (5) ◽  
pp. 596-601
Author(s):  
Christer Sylvén ◽  
Bengt Borgström
Keyword(s):  
Lymphatic Transport

Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat

2021 ◽  
Vol 596 ◽  
pp. 120247
Author(s):  
Given Lee ◽  
Sifei Han ◽  
Zijun Lu ◽  
Jiwon Hong ◽  
Anthony R.J. Phillips ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Systemic Exposure ◽  
Chain Fatty Acid ◽  
Lymphatic Transport ◽  
Long Chain Fatty Acid ◽  
Intestinal Delivery ◽  
Acid Formulation ◽  
Long Chain

scholarly journals An update on oral drug delivery via intestinal lymphatic transport

2021 ◽  
Author(s):  
Zichen Zhang ◽  
Yi Lu ◽  
Jianping Qi ◽  
Wei Wu
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Lymphatic Transport

scholarly journals Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe

2020 ◽  
Vol 6 (50) ◽  
pp. eabc2697
Author(s):  
Kim Pin Yeo ◽  
Hwee Ying Lim ◽  
Chung Hwee Thiam ◽  
Syaza Hazwany Azhar ◽  
Caris Tan ◽  
...  
Keyword(s):  
Lymphatic Vessels ◽  
Lymphatic Drainage ◽  
Lymphatic Transport ◽  
Atherosclerotic Plaques ◽  
Tissue Fluid ◽  
Atherosclerosis Progression ◽  
Lymphatic Vasculature ◽  
Lesion Regression ◽  
Transport Of Macromolecules

A functional lymphatic vasculature is essential for tissue fluid homeostasis, immunity, and lipid clearance. Although atherosclerosis has been linked to adventitial lymphangiogenesis, the functionality of aortic lymphatic vessels draining the diseased aorta has never been assessed and the role of lymphatic drainage in atherogenesis is not well understood. We develop a method to measure aortic lymphatic transport of macromolecules and show that it is impaired during atherosclerosis progression, whereas it is ameliorated during lesion regression induced by ezetimibe. Disruption of aortic lymph flow by lymphatic ligation promotes adventitial inflammation and development of atherosclerotic plaque in hypercholesterolemic mice and inhibits ezetimibe-induced atherosclerosis regression. Thus, progression of atherosclerotic plaques may result not only from increased entry of atherogenic factors into the arterial wall but also from reduced lymphatic clearance of these factors as a result of aortic lymph stasis. Our findings suggest that promoting lymphatic drainage might be effective for treating atherosclerosis.

scholarly journals PARTICIPATION OF PHOSPHOLIPIDES IN LYMPHATIC TRANSPORT OF ABSORBED FATTY ACIDS

1951 ◽  
Vol 189 (1) ◽  
pp. 261-267 ◽  
Author(s):  
B. Bloom ◽  
I.L. Chaikoff ◽  
W.O. Reinhardt ◽  
W.G. Dauben
Keyword(s):  
Fatty Acids ◽  
Lymphatic Transport

Ezetimibe Inhibits Lymphatic Transport of Esterified Cholesterol but Not Free Cholesterol in Thoracic Lymph Duct-Cannulated Rats

2012 ◽  
Vol 26 (5) ◽  
pp. 427-431 ◽  
Author(s):  
Bungo Shirouchi ◽  
Yuri Nakamura ◽  
Yumiko Furukawa ◽  
Aya Shiraishi ◽  
Hiroko Tomoyori ◽  
...  
Keyword(s):  
Free Cholesterol ◽  
Lymphatic Transport ◽  
Lymph Duct

Effect of soy protein and casein intake on intestinal absorption and lymphatic transport of cholesterol and oleic acid

1984 ◽  
Vol 40 (6) ◽  
pp. 1156-1164 ◽  
Author(s):  
G V Vahouny ◽  
W Chalcarz ◽  
S Satchithanandam ◽  
I Adamson ◽  
D M Klurfeld ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Intestinal Absorption ◽  
Soy Protein ◽  
Lymphatic Transport
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