Nanotechnology for Vaginal Drug Delivery and Targeting

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL). The physicochemical properties of the optimal MS (MS F) were characterized. Depending on the gelation temperature and gelating time, the optimal CTS-sodium alginate- (SA-) α,β-glycerophosphate (GP) (CTS-SA-GP) hydrogel was obtained. Observed by scanning electron microscope (SEM), TFV/BSP/CTS MS were successfully encapsulated in CTS-SA-GP. In vitro releasing demonstrated that MS F-CTS-SA-GP retained desirable in vitro sustained-release characteristics as a vaginal delivery system. Bioadhesion measurement showed that MS-CTS-SA-GP exhibited the highest mucoadhesive strength. Collectively, MS-CTS-SA-GP holds great promise for topical applications as a sustained-release vaginal drug delivery system.

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Polymer-based nanocarriers for vaginal drug delivery

Advanced Drug Delivery Reviews ◽

10.1016/j.addr.2014.12.004 ◽

2015 ◽

Vol 92 ◽

pp. 53-70 ◽

Cited By ~ 56

Author(s):

José das Neves ◽

Rute Nunes ◽

Alexandra Machado ◽

Bruno Sarmento

Keyword(s):

Drug Delivery ◽

Vaginal Drug Delivery

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Nanocarriers For Vaginal Drug Delivery

Recent Patents on Drug Delivery & Formulation ◽

10.2174/1872211313666190215141507 ◽

2019 ◽

Vol 13 (1) ◽

pp. 3-15 ◽

Cited By ~ 3

Author(s):

Zeenat Iqbal ◽

Fahima Dilnawaz

Keyword(s):

Drug Delivery ◽

Conventional Treatment ◽

Literature Search ◽

Relevant Literature ◽

Extensive Literature ◽

Treatment Approaches ◽

Vaginal Drug Delivery ◽

Extensive Literature Search ◽

Cyclic Changes ◽

Delivery Approach

Background:Vaginal drug delivery approach represents one of the imperative strategies for local and systemic delivery of drugs. The peculiar dense vascular networks, mucus permeability, and range of physiological characteristics of the vaginal cavity have been exploited for therapeutic benefit. Furthermore, the vaginal drug delivery has been curtailed due to the influence of different physiological factors like acidic pH, constant cervical secretion, microflora, cyclic changes during periods along with turnover of mucus of varying thickness.Objective:This review highlights advancement of nanomedicine and its prospective progress towards the clinic.Methods:Relevant literature reports and patents related to topics are retrieved and used. Result: The extensive literature search and patent revealed that nanocarriers are efficacious over conventional treatment approaches.Results:The extensive literature search and patent revealed that nanocarriers are efficacious over conventional treatment approaches.Conclusion:Recently, nanotechnology based drug delivery approach has promised better therapeutic outcomes by providing enhanced permeation and sustained drug release activity. Different nanoplatforms based on drugs, peptides, proteins, antigens, hormones, nucleic material, and microbicides are gaining momentum for vaginal therapeutics.

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