Imaging and Particle Therapy

2018 ◽  
pp. 67-94
Author(s):  
G. Landry ◽  
G. Dedes ◽  
M. Pinto ◽  
K. Parodi
Keyword(s):  
2020 ◽  
Vol 1548 ◽  
pp. 012020
Author(s):  
M De Simoni ◽  
M Fischetti ◽  
E Gioscio ◽  
M Marafini ◽  
R Mirabelli ◽  
...  

Author(s):  
N.J. Laperriere

ABSTRACT:The management of patients with supratentorial malignant astrocytomas has remained a major problem. Patients continue to die from a lack of local control in 90% of cases despite an improvement of median survival seen with the use of postoperative radiation therapy. Because of this, there has been considerable interest in exploring novel ways of possibly improving results. This paper reviews the rationale and clinical results with the use of altered fractionation schemes, brachytherapy, radiation sensitizers, hyperthermia, particle therapy, and radiosurgery in the treatment of these patients. Currently, there is no demonstrated advantage with the use of these experimental modalities in the initial management of patients. There would appear to be some benefit for selected patients who are treated with brachytherapy at recurrence, but its efficacy as part of initial management remains to be determined in ongoing randomized prospective trials.


Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 893
Author(s):  
Luc Rochette ◽  
Marianne Zeller ◽  
Yves Cottin ◽  
Catherine Vergely

Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons (H+) and molecular hydrogen (H2) in the cell are critical in a wide variety of processes. A new cancer treatment uses H2, a biologically inactive gas. Due to its small molecular weight, H2 can rapidly penetrate cell membranes and reach subcellular components to protect nuclear DNA and mitochondria. H2 reduces oxidative stress, exerts anti-inflammatory effects, and acts as a modulator of apoptosis. Exogenous H2, administered by inhalation, drinking H2-rich water, or injecting H2-rich saline solution, is a protective therapy that can be used in multiple diseases, including cancer. In particle therapy, cyclotrons and synchrotrons are the accelerators currently used to produce protons. Proton beam radiotherapy (PBT) offers great promise for the treatment of a wide variety of cancers due to the sharp decrease in the dose of radiation at a defined point. In these conditions, H2 and different types of H2 donors may represent a novel therapeutic strategy in cancer treatment.


2011 ◽  
Vol 29 (3) ◽  
pp. 135 ◽  
Author(s):  
Seo Hyun Park ◽  
Jin Oh Kang
Keyword(s):  

2021 ◽  
pp. 100772
Author(s):  
Mimoza M. Ristova ◽  
Vesna Gershan ◽  
Herwig Schopper ◽  
Ugo Amaldi ◽  
Manjit Dosanjh

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