Effect of Modified Hydroxypropyl Tapioca Starch and Percentage of Drug Loading on Physical Property of Paracetamol Tablet

2020 ◽  
Vol 859 ◽  
pp. 3-8
Author(s):  
Vipaluk Patomchaiviwat ◽  
Sontaya Limmatvapirat ◽  
Chaisai Sirisapaya ◽  
Rohanee Kolae ◽  
Kulmanee Anantakul ◽  
...  
Keyword(s):  
Drug Loading ◽  
Physical Property ◽  
High Hardness ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Tapioca Starch ◽  
Drug Concentrations ◽  
Model Drug ◽  
Better Than

The objective of this study was to investigate the effect of modified hydroxypropyl tapioca starch (HPTS) and % drug loading on physical property of tablet. Paracetamol was used as model drug because of its poor compressibility. The filler ability of modified HPTS such as hydroxyl propyl oxidized tapioca starch (HPOTS), hydroxyl propyl crosslinked tapioca starch (HPCTS) and pregelatinized tapioca starch (PTS) were evaluated and compared with the commercial starch (Starch 1500®). Tablets were prepared by direct compression method and the percent drug loading were 15, 30, 45, 60, 75%. For modified HPTS, the hardness of the tablets tended to decrease when the concentration of paracetamol increased. At drug concentrations of 15-30%, HPOTS exhibited good performance of tablet as indicated by the high hardness, low friability and acceptable disintegration time. The obtained results were better than HPTS and comparable to Starch 1500®. Moreover, the results revealed that tablet containing PTS provided the highest hardness and prolonged disintegration time (>30 min) while tablet containing HPCTS showed rapid disintegration time (<2 min). Therefore, modified HPTS disclosed promising properties for application as tablet filler

Modification of Starch Extracted from Black Glutinous Rice (Oryza sativa L, Variety Leum Pua) as Tablet Filler

2014 ◽  
Vol 1060 ◽  
pp. 58-61
Author(s):  
Vipaluk Patomchaiviwat ◽  
Suchada Piriyaprasarth ◽  
Bunyarit Chaisomboonphan ◽  
Chitatharinth Limpoemwuttiporn ◽  
Pornsuda Nuamnoi
Keyword(s):  
Oryza Sativa ◽  
Oryza Sativa L ◽  
Rice Starch ◽  
Wet Granulation ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Glutinous Rice ◽  
Model Drug ◽  
Fast Disintegrating Tablets

The aim of this study was to investigate the modification of black glutinous rice starch (BGRS) as tablet filler. The black glutinous rice was treated with NaCl and NaOH to obtain BGRS. The native BGRS was modified by pregelatinizaion and prepared as co-composite and used as filler in tablet formulation compared with Starch 1500®. Propranolol was used as a model drug. The properties of tablets including disintegration time were evaluated. Interestingly, the disintegration times of the native BGRS was less than 90s which was faster than Starch 1500®. The results suggest that the native BGRS would be used in fast disintegrating tablets. While the disintegration times of pregelatinized BGRS was more than 30 min. Thus, the pregelatinized BGRS might be used for sustained release tablet. For the co-composite method, PVP K90 in the concentration of 1, 3, 5, 7 and 9 % w/w was incorporated with BGRS. The tablets of the co-composite producing by direct compression method were compared with tablets producing by wet granulation method using PVP K90 as binder. In concentration of 3% w/w PVP K90, the co-composite was comparable to wet granulation method in term of hardness and disintegration time. Thus, it could be used as direct compression filler in pharmaceutical field.

scholarly journals Formulation and evaluation of fast dissolving tablets of captopril

2021 ◽  
Vol 17 (2) ◽  
pp. 123-130
Author(s):  
Akash S Ingale ◽  
Sandhya S Ahire ◽  
Sujeetkumar I Ahire ◽  
Parag R. Patil
Keyword(s):  
Protein Delivery ◽  
Competitive Inhibitor ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Oral Protein Delivery ◽  
Rate Of Dissolution ◽  
Weight Protein ◽  
Model Drug ◽  
Mouth Feel

Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. The development of enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in the mouth are very promising for the delivery of high molecular weight protein and peptide. Good mouth feel property of MDDS helps to change the basic view of medication as “bitter pill”, particularly for pediatric patients. To prepare mouth dissolving tablet using SSG & CCM by using Antihypertensive as model drug. Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme and it is a key component of the renin-angiotensin-aldosterone system. The ƛmax of Captopril was determined by scanning the 10µg / ml solution of drug using UV-Spectrophotometer and was found to be 271nm. The linear correlation was found to be 0.9995.The Fast dissolving tablets of captopril were prepared by direct compression method. Captopril can be successfully formulated as mouth dissolving tablets using various super disintegrate in different concentrations by direct compression method. The formulation containing 10% of crospovidone as super disintegrated was found to be outstanding than other formulations in terms of disintegration time and rate of dissolution.

scholarly journals FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS

2017 ◽  
Vol 9 (4) ◽  
pp. 92
Author(s):  
Hrishav Das Purkayastha ◽  
Bipul Nath
Keyword(s):  
Drug Release ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Rapid Release ◽  
Weight Variation ◽  
Fast Disintegrating Tablet

Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magnesium stearate and compressed into tablets using the Cadmach single punch (round shaped, 8 mm thick) machine.Results: Physicals parameters of the prepared tablets like Hardness, Weight variation, Friability, thickness, drug content etc. found within the limits. The disintegration time of prepared ODTs was in the range of 45 to 55 seconds. In vitro dispersion time was found to be 22 to 52 seconds which may be attributed to faster uptake of water due to the porous structure formed by super disintegrants. Short disintegration and faster release of ibuprofen were observed with Cross carmellose sodium as compared to sodium starch glycollate.Conclusion: It is concluded that F3 offered the relatively rapid release of Ibuprofen when compared with other formulations. The increase in the concentrations of super disintegrants may lead to increase in the drug release. The formulation prepared with cross carmellose sodium was offered the relatively rapid release of Ibuprofen when compared with other concentrations of both the super disintegrant. 

scholarly journals Preparation and evaluation of diclofenac sodium orally disintegrating tablets

2016 ◽  
Vol 27 (1) ◽  
pp. 58-61
Author(s):  
Valeriu Iancu ◽  
Florentina Roncea ◽  
Radu George Cazacincu ◽  
Dumitru Lupuleasa
Keyword(s):  
Diclofenac Sodium ◽  
Magnesium Stearate ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Preparation And Evaluation

Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.

Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels

2011 ◽  
Vol 121-126 ◽  
pp. 1764-1768
Author(s):  
Li Li Ruan ◽  
Da Xin Wang ◽  
You Wei Zhang ◽  
Jiong Xin Zhao ◽  
Min Wu Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Size Distribution ◽  
Organic Solvents ◽  
Drug Loading ◽  
Average Diameter ◽  
Preparation Condition ◽  
The Other ◽  
Distribution Index ◽  
Model Drug ◽  
Better Than

This study was to prepare polycaprolactone (PCL) nanoparticles. The biodegradable PCL was used as the carrier, and Azithromycin (AZM) was used as the model drug. AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method. The effect of preparation condition: concentration of PCL, molecular weight of PCL, organic solvents, dosage ratio and so on, were specially noted and compared. A homogeneous size distribution and good dispersion were observed, the average diameter was around 70~400 nm, and the distribution index was 0.036~0.136. The drug loading reached 27.69 %, and the efficiency of encapsulation reached as high as 93.25%. The results were better than the other similar researches, this preparation way was successful.

scholarly journals Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

2021 ◽  
Vol 11 (2) ◽  
pp. 42-50
Author(s):  
Vandana Gupta ◽  
Ashish Manigauha
Keyword(s):  
Comparative Investigation ◽  
Gel Strength ◽  
Tablet Formulation ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Compression Method ◽  
Reaction Conditions ◽  
Disintegration Time ◽  
Evaluation Parameters ◽  
Chemical Cross Linking

The purpose of present exploration was to modify kappa (k)-Carrageenan, by crosslinking, and assessed it as a tablet disintegrant to strengthen the solubility of the drug (aceclofenac) in tablet formulation. Modified k-Carrageenan was synthesized by reacting it with epichlorhydrin at heterogenous  conditions. The swelling action of the product was investigated in order to optimize reaction circumstances for chemical cross-linking. Best modified k-Carrageenan procured by optimizing the reaction conditions and it was characterized for swelling index, particle size distribution, solubility, viscosity, gel strength and Fourier transform infrared spectroscopy (FTIR). Influence of modified k-Carrageenan on dissolution profile of therapeutic was also investigated along with other evaluation parameters. Modified k-Carrageenan exhibiting significant swelling index which is comparable to that of superdisintegrants. On comparative investigation as a tablet disintegrant by preparing anhydrous dicalcium phosphate tablet, modified k-Carrageenan showed disintegration time less than 20 seconds. Dissolution of aceclofenac (Class II) tablet formulaion utilizing modified k-Carrageenan was comparable with commercially available superdisintegrants. Faster dissolution of the accommodated drug was achieved with modified k-Carrageenan which was comparable with dissolution of the tablet formulation containing other superdisintegrants. The competent concentration of k-Carrageenan was found to be 5-15% as tablet disintegrant. Modified k-Carrageenan might be encouraging tablet disintegrant in fast dissolving formulations and can be worn in direct compression method. Keywords: k-Carageenan. Epichlorhydrin. Aceclofenac. Crosslinking. Superdisintegrant

Formulation and Evaluation of Fast Dissolving Tablet of Ondansetron by Utilizing Liquisolid Compact Technique

2021 ◽  
pp. 163-168
Author(s):  
Sanket Jain ◽  
Sujit Pillai ◽  
Rampal Singh Mandloi ◽  
Nikhlesh Birla
Keyword(s):  
Drug Release ◽  
In Vitro Dissolution ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Dissolution Studies ◽  
Drug Content ◽  
Ftir Studies ◽  
Site Of Action

Ondansetron is an anti-emetic drug which is insoluble in water. The present study was aimed to formulate and evaluate oral fast dissolving tablet of Ondansetron by Utilizing Liquisolid Compact Technique. The tablets were prepared by direct compression method and characterized by UV, FTIR studies. Six formulations (F1-F6) of ondansetron were prepared and tablets were evaluated for weight variations, hardness, thickness, friability, disintegration time, drug content and In-vitro dissolution studies gave satisfactory result. TF6 was found to be the best and acceptable formulation whose drug content was about 99.17±0.05 and percentage (%) drug release 97.49±2.03 in 10 min, high as compare to other formulation and has low disintegration time 17±0.01 as compare to other formulation which indicates that drug is rapidly dissolved and available at the site of action.

scholarly journals Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 423 ◽  
Author(s):  
Domínguez-Robles ◽  
Stewart ◽  
Rendl ◽  
González ◽  
Donnelly ◽  
...  
Keyword(s):  
Drug Loading ◽  
Antioxidant Properties ◽  
Maximum Amount ◽  
Release Profile ◽  
Direct Compression ◽  
Compression Force ◽  
Crushing Strength ◽  
Pharmaceutical Excipient ◽  
Tablet Manufacturing ◽  
Model Drug

Extensive efforts are being made to find alternative uses for lignin (LIG). In the present work the use of this biopolymer as excipient to prepare tablets was studied. For this purpose, LIG was combined with microcrystalline cellulose (MCC) and used as excipients to prepare directly compressed tablets containing a model drug, tetracycline (TC). The excipients contained different concentrations of LIG: 100%, 75%, 50%, 25% and 0% (w/w). Two different compression forces were used (two and five tonnes). When formulations were prepared using LIG as the only excipient, tablets were formed, but they showed lower densities and crushing strength than the ones obtained with only MCC or LIG/MCC blends. Moreover, tablets prepared using five tonnes of compression force showed TC releases ranging from 40% to 70% of the drug loading. On the other hand, the tablets prepared using two tonnes of compression force showed a faster and more efficient TC release, between 60% and 90%. The presence of LIG in the tablets modified significantly the release profile and the maximum amount of TC released. Finally, a DPPH (2,2-diphenyl-1-picrylhydrozyl) assay was performed to confirm that the presence of LIG provided antioxidant properties to the formulations. Accordingly, LIG has potential as a pharmaceutical excipient.

scholarly journals Formulation and Evaluation of Rapimelt Tablet of Anti-Vertigo Drug (Lorazepam)

2020 ◽  
Vol 13 (4) ◽  
pp. 341-349
Author(s):  
B. M. Kadu ◽  
S. Bhasme ◽  
R. D. Bawankar ◽  
D. R. Mundhada
Keyword(s):  
Rapid Onset ◽  
Dissolution Time ◽  
Direct Compression ◽  
Compression Method ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Ft Ir ◽  
Wetting Time ◽  
Mouth Feel

A. Rapimelt tablet of Lorazepam was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants with aim to get rapid onset of action, improve bioavailability and to give pleasant taste and better mouth feel. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and invitro dissolution time and were found to be within limits as per Indian Pharmacopoeia. FT-IR spectra of physical mixture of Lorazepam with Indion 414showedretention of basic peaks of Lorazepam. The developed formulation of Lorazepam batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Crosscarmellose Sodium batches F1-F3 and Sodium starch glycolate batches F6-F9.

scholarly journals CAUSE-EFFECT RELATIONS AND OPTIMIZATION OF TABLET CONTAINING EUCOMMIA ULMOIDES AND GARDENIA JASMINOIDES SPRAY-DRIED EXTRACTS

2018 ◽  
Vol 10 (7) ◽  
pp. 33
Author(s):  
Vo Thanh Hoa ◽  
Bui Thi Thu Huong ◽  
Do Quang Duong ◽  
Nguyen Duc Hanh
Keyword(s):  
Tablet Formulation ◽  
Direct Compression ◽  
Compression Method ◽  
Active Ingredients ◽  
Disintegration Time ◽  
Independent Variables ◽  
Gardenia Jasminoides ◽  
Weight Variation ◽  
Dried Extract ◽  
Spray Dried

Objective: The E. ulmoides and G. jasminoides (EG) tablets containing 67 mg E. ulmoides spray-dried extract (ESE) and 173 mg G. jasminoides spray-dried extract (GSE) were prepared by employing the direct compression method. Due to the poor flowability and compressibility of the two spray-dried extracts, various excipients were added at different ratios so that the blends can be compressed into tablets with the required standards. This study aimed at the cause-effect relations and optimization of the EG tablet formulation.Methods: Different diluents including dibasic calcium phosphate anhydrous (DCPA), silicified microcrystalline cellulose (SMCC), spray-dried lactose (SDL) and the active ingredients (blend of ESE and GSE at the ratio of 67:173, w/w) were separately investigated their own physical properties. The binary mixtures of the active ingredients with different ratios of DCPA, SMCC, and SDL were evaluated their flowability. D-optimal design based on three independent variables (% DCPA, % croscarmellose sodium (CCS) and % SMCC) was applied to evaluate the cause-effect relations and optimize the EG tablet formulation. The weight variation, disintegration time, hardness and friability were investigated as four dependent variables.Results: The flowability of the powders was found to be affected by the particle size distribution, particle shape and density. The three diluents could significantly improve the flowability of the active ingredients. All independent variables had significant effects on the dependent variables. An increase in % SMCC reduced the weight variation, hardness and increased the friability of tablets. Disintegration time was found to be in the negative relations with % CCS. The tablet hardness was in positive relations with % DCPA. The optimized EG tablet formulation composed of 9 % DCPA (w/w), 35 % SMCC (w/w), and 14 % CCS (w/w) of the excipient blend. The weight variation, disintegration time, hardness and friability of the optimized EG tablets were found to be 1.8 %, 11.7 min, 61.4 N, and 0.5 %, respectively.Conclusion: The ESE and GSE could be formulated into tablet by using direct compression method. The cause-effect relations and optimization of EG tablet formulation were studied and reported for the first time.

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