scholarly journals Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor

2010 ◽  
Vol 31 (3) ◽  
pp. 403-403
Author(s):  
Lei Tian ◽  
Jie Gao ◽  
Jianqiang Hao ◽  
Yu Zhang ◽  
Huimin Yi ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Diabetic Mice ◽  
Cell Replication ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Onset Diabetes ◽  
Nonobese Diabetic Mice ◽  
New Onset

scholarly journals Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor

Endocrinology ◽  
2010 ◽  
Vol 151 (7) ◽  
pp. 3049-3060 ◽  
Author(s):  
Lei Tian ◽  
Jie Gao ◽  
Jianqiang Hao ◽  
Yu Zhang ◽  
Huimin Yi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nod Mice ◽  
Cell Replication ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Onset Diabetes ◽  
Dpp Iv ◽  
Tgf Β1 ◽  
New Onset

Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by NVP-DPP728, a DPP-IV inhibitor, improves the therapeutic efficacy of glucagon-like peptide-1 (GLP-1). CD26 is a membrane-associated glycoprotein with DPP-IV activity and is expressed on lymphocytes. We investigated the effect of NVP-DPP728 on reversing new-onset diabetes in nonobese diabetic (NOD) mice and modulating the inflammatory response and stimulating β-cell regeneration. New-onset diabetic NOD mice were treated with NVP-DPP728 for 2, 4, and 6 wk. Blood glucose level was monitored. Regulatory T cells in thymus and secondary lymph nodes, TGF-β1 and GLP-1 in plasma, and the insulin content in the pancreas were measured. Immunostaining for insulin and bromodeoxyuridine (BrdU) were performed. The correlation of β-cell replication with inflammation was determined. In NVP-DPP728-treated NOD mice, diabetes could be reversed in 57, 74, and 73% of mice after 2, 4, and 6 wk treatment, respectively. Insulitis was reduced and the percentage of CD4+CD25+FoxP3+ regulatory T cells was increased in treated NOD mice with remission. Plasma TGF-β1 and GLP-1, the insulin content, and both insulin+ and BrdU+ β-cells in pancreas were also significantly increased. No significant correlations were found between numbers of both insulin+ and BrdU+ β-cells in islets and β-cell area or islets with different insulitis score in NOD mice with remission of diabetes. In conclusion, NVP-DPP728 treatment can reverse new-onset diabetes in NOD mice by reducing insulitis, increasing CD4+CD25+FoxP3+ regulatory T cells, and stimulating β-cell replication. β-Cell replication is not associated with the degree of inflammation in NVP-DPP728-treated NOD mice.

Safety and Efficacy of Long-Term Administration of Dipeptidyl peptidase IV Inhibitors in Patients With New Onset Diabetes After Kidney Transplant

2021 ◽  
Vol 19 (5) ◽  
pp. 411-419
Author(s):  
Adamantia Mpratsiakou ◽  
Marios Papasotiriou ◽  
Theodoros Ntrinias ◽  
Konstantinos Tsiotsios ◽  
Evangelos Papachristou ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Safety And Efficacy ◽  
Onset Diabetes ◽  
Term Administration ◽  
Dipeptidyl Peptidase Iv Inhibitors ◽  
New Onset

scholarly journals B Cells Are Crucial for Determinant Spreading of T Cell Autoimmunity among β Cell Antigens in Diabetes-Prone Nonobese Diabetic Mice

2006 ◽  
Vol 176 (4) ◽  
pp. 2654-2661 ◽  
Author(s):  
Jide Tian ◽  
Dan Zekzer ◽  
Yuxin Lu ◽  
Hoa Dang ◽  
Daniel L. Kaufman
Keyword(s):  
T Cell ◽  
B Cells ◽  
Diabetic Mice ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Dietary Zinc Reduction, Pyruvate Supplementation, or Zinc Transporter 5 Knockout Attenuates β-Cell Death in Nonobese Diabetic Mice, Islets, and Insulinoma Cells

2012 ◽  
Vol 142 (12) ◽  
pp. 2119-2127 ◽  
Author(s):  
Christian T. Sheline ◽  
Chunxiao Shi ◽  
Toshihiro Takata ◽  
Julia Zhu ◽  
Wenlan Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Zinc Transporter ◽  
Diabetic Mice ◽  
Dietary Zinc ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Zinc Reduction ◽  
Nonobese Diabetic Mice ◽  
Insulinoma Cells

scholarly journals CXC Chemokine Ligand 10 Neutralization Suppresses the Occurrence of Diabetes in Nonobese Diabetic Mice through Enhanced β Cell Proliferation without Affecting Insulitis

2004 ◽  
Vol 173 (11) ◽  
pp. 7017-7024 ◽  
Author(s):  
Jiro Morimoto ◽  
Hiroyuki Yoneyama ◽  
Akira Shimada ◽  
Toshikatsu Shigihara ◽  
Satoru Yamada ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Diabetic Mice ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Cxc Chemokine ◽  
Chemokine Ligand ◽  
Nonobese Diabetic Mice

scholarly journals Perforin-independent β-cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice

1999 ◽  
Vol 103 (8) ◽  
pp. 1201-1209 ◽  
Author(s):  
Abdelaziz Amrani ◽  
Joan Verdaguer ◽  
Brad Anderson ◽  
Toshihiro Utsugi ◽  
Sonny Bou ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Diabetic Mice ◽  
Β Cell ◽  
Cell Destruction ◽  
Nonobese Diabetic ◽  
Cd8 T Lymphocytes ◽  
Nonobese Diabetic Mice
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