Insulin-like growth factors (IGFs) reduce IGF-binding protein-4 (IGFBP- 4) concentration and stimulate IGFBP-3 independently of IGF receptors in human fibroblasts and epidermal cells

Endocrinology ◽  
1992 ◽  
Vol 130 (2) ◽  
pp. 985-993 ◽  
Author(s):  
E. K. Neely
Keyword(s):  
Growth Factors ◽  
Binding Protein ◽  
Human Fibroblasts ◽  
Epidermal Cells ◽  
Igf Receptors ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

Growth hormone (GH), insulin-like growth factors (IGFs), and IGF-binding protein-3 (IGFBP-3) in a child with Proteus syndrome

1994 ◽  
Vol 50 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Günter Rudolph ◽  
Werner F. Blum ◽  
Enno W. Jenne ◽  
Martin Schöning ◽  
Herbert Enders ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Binding Protein ◽  
Proteus Syndrome ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

Modulation of insulin-like growth factors (IGF I-II) and IGF binding-protein 3 (IGFBP-3) through exercise training in women with breast cancer: A systematic review and meta-analysis.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 120-120
Author(s):  
Jose F Meneses-Echavez ◽  
Robinson Ramirez-Velez ◽  
Emilio Gonzalez-Jimenez ◽  
Jacqueline Schmidt Rio-Valle ◽  
Maria Jose Sanchez Perez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Waist Circumference ◽  
Exercise Training ◽  
Binding Protein ◽  
Serum Concentrations ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

120 Background: Epidemiological data suggest that Insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are associated with breast cancer risk, apoptosis and other carcinogenic mechanisms. This metaanalysis evaluates the effects of exercise interventions in controlling serum concentrations of Insulin-like growth factors (IGF1-IGF2) and IGFBP-3 in women with breast cancer. Methods: We incorporated the PRISMA statement. Databases of MEDLINE, Ovid, EMBASE and Cochrane Central Registers were searched to identify randomized controlled trials until March 2014, reporting effect estimates for IGF-1, IGF-2, IGFBP-3 and other secondary outcomes such as insulin, glucose and waist circumference as a body composition measure. An Inverse of variance (IV) with Mantel–Haenszel method was selected for analysis, and a random-effects models were used to assess the pooled estimates in addition to sensitivity analyses, whilst heterogeneity was evaluated using the Chi2 test (P<0.10) and I2 statistics (I2>50%).STATA 12.0 was used for metaanalysis procedures. Results: Six studies were included in the pooled analysis involving 321 patients. Effect estimates showed that exercise training improved IGF-1 (MD= -12.9, 95CI% -16.73 to -9.14, P<0.001), IGF-2 (MD= -43.4, 95CI% -58.5 to -28.3, P<0.001), IGFBP-3 (MD= -0.61, 95CI% -0.69 to -0.53, P<0.001) and waist circumference (MD= -1.133, 95CI% -2.20 to -0.05, P=0.03) in women with breast cancer. Conversely, non-significant differences were observed for Insulin (MD= 0.046, 95CI% -0.24 to 0.34, P=0.7), Glucose (MD=0.22, 95CI% -0.32 to 0.78, P=0.419) and Insulin Resistance (MD= 0.64, 95CI% -0.006 to 1.29, P= 0.06). There was no evidence of publication bias. Conclusions: Exercise is an effective and safe intervention in improving the serum concentrations of insulin like growth factors (IGF1-IGF2) and IGFBP-3 in women with breast cancer, strengthening the physiological effects of exercise in regulating cellular proliferation and apoptosis in breast cancer. Further evidences are encouraged.

scholarly journals POSTNATAL SERUM INSULIN LIKE GROWTH FACTORS (IGFS) AND IGF BINDING PROTEIN 3(IGFBP-3) IN VLBW INFANTS. † 1461

1996 ◽  
Vol 39 ◽  
pp. 246-246
Author(s):  
A Sobowale ◽  
S. Y Wu ◽  
R. S Pildes ◽  
S Ehmann ◽  
S. P Singh
Keyword(s):  
Growth Factors ◽  
Binding Protein ◽  
Serum Insulin ◽  
Vlbw Infants ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

Developmentally regulated expression of insulin-like growth factors by differentiated murine teratocarcinomas and extraembryonic mesoderm

Development ◽  
1986 ◽  
Vol 95 (1) ◽  
pp. 193-212
Author(s):  
John K. Heath ◽  
Wai-Kang Shi
Keyword(s):  
Plasma Membrane ◽  
Binding Protein ◽  
Membrane Receptors ◽  
Developmentally Regulated ◽  
Igf Receptors ◽  
Igf Binding ◽  
Plasma Membrane Receptors ◽  
Igf Binding Protein ◽  
Culture Supernatants ◽  
Insulin Like Growth Factors

The expression of plasma membrane receptors for insulin-like growth factors (IGFs) by PC13 embryonal carcinoma (EC) cells, and their immediate differentiated progeny PC13END was examined by binding radiolabelled IGF-I to cell monolayers. Both cell types express high-affinity IGF receptors, but the apparent number of unoccupied receptor sites falls by about 60% upon differentiation. Crosslinking studies reveal that both type 1 and type 2 IGF receptors are expressed by PC13EC cells. PC13END-cell-conditioned medium contains developmentally regulated, separable activities, one of which reacts directly with IGF-II, and the other with IGF for plasma membrane receptors. The former activity represents a soluble secreted IGF-binding protein. The latter activity is structurally and functionally similar to rat IGF-II. Polyclonal antibodies raised against purified rat IGF-II specifically recognize multiple forms of IGF in radiolabelled culture supernatants and material which closely resembles the soluble IGF-binding protein. Immunoprecipitation of radiolabelled culture supernatants with anti-rat IGF-II reveals that the differentiation of PC13EC cells is accompanied by the coexpression of IGF-like molecules and the soluble binding protein, and that IGF-like molecules are expressed by extraembryonic tissues of mesodermal origin in the early postimplantation mouse embryo. These findings show that IGF-like molecules are expressed in early mammalian development and may act in an autocrine fashion in vivo.

Evaluation of the insulin-like growth factors (IGF) IGF-I and IGF binding protein 3 in patients at high risk for breast cancer

2011 ◽  
Vol 95 (8) ◽  
pp. 2753-2755 ◽  
Author(s):  
Angela F. Trinconi ◽  
José Roberto Filassi ◽  
José Maria Soares-Júnior ◽  
Edmund C. Baracat
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
High Risk ◽  
Binding Protein ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Insulin Like Growth Factors
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