The Relationship between Plasma Omentin Levels and Insulin Resistance in Newly Diagnosed Type 2 Diabetic Patients.

2010 ◽  
pp. P1-497-P1-497
Author(s):  
NG Kirnap ◽  
G Gursoy ◽  
O Esbah ◽  
Y Acar ◽  
B Demirbas
Keyword(s):  
Insulin Resistance ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Type 2 Diabetic Patients ◽  
The Relationship ◽  
Type 2 Diabetic

scholarly journals Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients

2014 ◽  
Vol 170 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Guoyu Tong ◽  
Xiaomin Hua ◽  
Yingjie Zhong ◽  
Kui Zhang ◽  
Guangyu Gu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Therapy ◽  
Sex Hormone Binding Globulin ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Hormone Binding ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Type 2 Diabetic

ObjectiveMany studies have shown that low sex hormone-binding globulin (SHBG) is associated with insulin resistance, but only few studies have examined how serum SHBG is regulated by insulin in humans. This interventional study aimed to investigate the effect of insulin therapy (IT) on serum SHBG levels in newly diagnosed type 2 diabetic patients.MethodsA total of 80 newly diagnosed type 2 diabetic subjects were enrolled and randomly grouped into a 2-week intensive IT with/without metformin. Serum SHBG, total testosterone, glucose, liver enzymes, lipids, insulin, and C-peptide levels were measured before and after IT.ResultsBefore IT, serum SHBG levels were negatively correlated with BMI, waist circumference (WC), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GT), triglyceride (TG), fasting insulin, and C-peptide, and homeostatic model assessment of insulin resistance (HOMA-IR), and positively with HDL-C (all P for trend <0.05), after adjustment for age and sex. IT increased serum SHBG levels from 26.5±14.5 to 33.2±15.0 nmol/l (P<0.001), increased by 25.2% (95% CI, 20.3 to 30.9%, P<0.001). In a multiple linear regression model adjusting for age, sex, BMI, and WC, the decreases in ΔALT (standardized regression coefficient β=−0.374, P=0.012) and ΔTG (β=−0.380, P=0.020) were independent contributors to the increase in ΔSHBG.ConclusionsIT increases serum SHBG likely through improving insulin resistance and liver function.

scholarly journals Serum ErbB2 concentration positively correlated to the glycemic variations in newly diagnosed Type 2 diabetic patients

2020 ◽  
Author(s):  
Yan Huang ◽  
Xia Han ◽  
Feng-fei Li ◽  
Yan-mei Liu ◽  
Zelong Liu ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Mean Amplitude ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Type 2 Diabetic Patients ◽  
Mean Glucose ◽  
The Relationship ◽  
Type 2 Diabetic ◽  
Glycemic Variations

Abstract Background Accumulated evidences indicate that elevated levels of circulating ErbB2 are closely associated with increased incidence of diabetes. However, the relationship between ErbB2 concentration and glycemic variations (GV) in type 2 diabetic (T2D) patients remains elucidated. The aim of this study was to assess whether there is an association between serum ErbB2 concentration and GV in newly diagnosed T2D patients. Methods This was a three-center, and observational study. Between April 2019 and July 2019, a total of 106 newly diagnosed T2D patients were recruited. All recruited subjects were admitted as inpatients and received anti-diabetes agents free during the study period. At baseline, fasting serum was collected for ErbB2 measurement and all recruited patients were subjected a prospective CGM for at least 3 days. The primary endpoint was the relationships between ErbB2 concentrations and GV in T2D patients. Results Data of a total of 95 subjects who met the inclusion criteria were analyzed at the endpoint. Subjects were divided into quartiles according to their serum ErbB2 concentrations. We observed that subjects with an elevated level of ErbB2 had a higher value of GV in terms of mean amplitude of glucose excursion (MAGE), standard deviation of mean glucose (SDMG), and the coefficient of variation (CV%) than those with lower levels (all P<0.05). Multiple linear regression analyzes after adjusting for confounder factors indicate that serum ErbB2 levels were significantly positively correlated with the MAGE (β=0.664, t=7.218, P<0.01), SD (β=0.469, t=5.125, P<0.01) and CV% (β=0.337, t=4.442, P<0.01), respectively. Conclusion Serum ErbB2 concentration was positively correlated to the glycemic variations in newly diagnosed T2D patients. Our data indicating that ErbB2 may be a potential treatment target for diabetic patients for improvement in glycemic control. Keywords Type 2 Diabetes, glycemic control, ErbB2

scholarly journals Frequency of Hyperlipidemia in the Diagnosed Type 2 Diabetic Patients

2021 ◽  
Vol 8 (1) ◽  
pp. 25-30
Author(s):  
Shama Iqbal ◽  
Ambreen Gul ◽  
Rashid Ahmad ◽  
Momina Haq ◽  
Sara Maryam ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Descriptive Study ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Primary Event ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
The World ◽  
Type 2 Diabetic

OBJECTIVES: The primary event in the development of type-2 diabetes is directly associated with lipid metabolism derangement occurring due to insulin resistance. The aim of this study was to find out the prevalence of hyperlipidemia in the newly diagnosed type-2 DM. METHODOLOGY: This hospital based descriptive study was conducted in the year 2018 to 2019, on 100 newly diagnosed type-2 diabetic patients attending medical O.P.D or admitted in medial wards of Naseer Ullah Khan Babar Memorial Hospital Kohat Road Peshawar. RESULTS: The incidence of hyperlipidemia in newly diagnosed diabetic patients was 29%. About 71% patients were having normal lipid profile. Our study also revealed that the frequency of hyperlipidemia increases with age. Half of the patients having age more than 60 years developed hyperlipidemia. Among hyperlipidemic patients, hypercholesterolemia was present in 36% and hypertriglyceridemia in 64% patients CONCLUSION: The study suggests that hyperlipidemia is very common in newly diagnosed type-2 diabetic patients in this part of the world.  

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