LDL cholesterol/HDL cholesterol ratio in newly diagnosed type 2 diabetic patients complicated with metabolic syndrome

Abstract Introduction. The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls. Methods. The study included 60 patients with type 2 diabetes and 30 healthy individuals as control groups. Biochemical parameters and progranulin levels were determined. Results. Subjects with metabolic syndrome showed significantly higher levels of triglyceride, waist circumference, BMI, systolic and diastolic blood pressure than subjects without metabolic syndrome and the control groups, while HDL-cholesterol level was significantly lower in subjects with metabolic syndrome. Fasting blood sugar was significantly higher in type 2 diabetic patients than in the control groups. Serum level of progranulin was slightly increased in subjects with metabolic syndrome. Serum progranulin level had no significant relationship with metabolic syndrome components. Conclusions. Serum progranulin was also not dependent on cardiometabolic risk factors for subjects with metabolic syndrome, but it could be considered for the management of type 2 diabetes mellitus. Further studies are recommended to explain the effect of progranulin on the pathogenesis of metabolic risk factors.

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HUBUNGAN GLYCATED ALBUMIN DENGAN ANGKA BANDING KOLESTEROL LDL/LDH DI DIABETES MELITUS TIPE 2 (Association of Glycated Albumin with LDL/HDL Cholesterol Ratio in Type 2 Diabetics)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v22i1.1216 ◽

2018 ◽

Vol 22 (1) ◽

pp. 16

Author(s):

Tiwik Eriskawati ◽

Tahono Tahono ◽

M.I. Diah. P

Keyword(s):

Glycated Albumin ◽

Hdl Cholesterol ◽

P Value ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Chi Square ◽

Cross Sectional ◽

Cholesterol Ratio ◽

Type 2 Diabetic

Diabetes causes about 5% of all deaths globally each year. Glycated hemoglobin has been routinely used as a biomarker for long-termglycemic control. Glycated albumin is an intermediate glycemic marker, a potent atherogenic protein, which plays a role in developingatherosclerosis. LDL/HDL cholesterol ratio can be used to assess the risk of cardiovascular disease caused by impaired lipid metabolismin type 2 diabetic patients. The aim of this study was to know the association between GA and HbA1c with LDL/HDL cholesterol ratioin type 2 diabetic patients. The study was carried out by a cross sectional design. Eighty four type 2 diabetic patients admitted to theInternal Medicine Outpatient Clinic of the Dr. Moewardi Hospital who met the study inclusion criteria were studied. Linear Regressionand Chi Square tests were used to analyze the data, p value of <0.05 was considered statistically significant, with the confidenceinterval of 95%. In this study, significant associations between GA and HbA1c with LDL/HDL cholesterol ratio (R=0629 and R=0.501,p=0.001) were found. Type 2 diabetic patients with GA ≥17% obtaining LDL/HDL cholesterol ratio >1.85 was 10.33 greater thanthose of with GA <17% (RP=10.33; CI 95%; 1.01–109.49; p=0.018). While type 2 diabetic patients with HbA1c ≥7% obtaining anLDL/HDL cholesterol ratio >1.85 was 12.76 greater than those with HbA1c <7%, but was statistically not significant (RP=12.76; CI95%; 0.66–245; p=0.017). Based on this study it can be concluded that GA can be used to predict LDL/HDL cholesterol ratio. Thus,GA is superior to HbA1c in predicting LDL/HDL cholesterol ratio.

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Increased Ability of LDL from Normolipidemic Type 2 Diabetic Women to Generate Peroxides

Clinical Chemistry ◽

10.1093/clinchem/45.9.1439 ◽

1999 ◽

Vol 45 (9) ◽

pp. 1439-1448 ◽

Cited By ~ 14

Author(s):

Bruno Guerci ◽

Helena Antebi ◽

Laurent Meyer ◽

Vincent Durlach ◽

Olivier Ziegler ◽

...

Keyword(s):

Ldl Cholesterol ◽

Thiobarbituric Acid ◽

Significant Negative Correlation ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cholesterol Ratio ◽

Type 1 Diabetic Patients ◽

Type 2 Diabetic

Abstract Background: We assessed the ability of LDL from 30 type 1 diabetic patients (18 men, 12 women), 65 type 2 diabetic patients (35 men, 30 women), and 35 controls (19 men, 16 women) to generate peroxides. The men and women in the diabetic groups were studied separately and matched for age, body mass index, duration of diabetes, glycohemoglobin, and conventional lipid characteristics according to the presence or absence of hyperlipidemia. Methods: The ability of LDL to form peroxides was assessed by measuring the thiobarbituric acid-reactive substances corrected for LDL-cholesterol [ratio of malondialdehyde (MDA) to LDL-cholesterol]. LDL particle size was expressed as the ratio of LDL-cholesterol to apolipoprotein B (LDL-cholesterol/apoB). Results: The MDA/LDL-cholesterol ratio was higher in type 1 and type 2 diabetic patients with hyperlipidemia than in controls. The MDA/LDL-cholesterol ratio was also higher in type 2 normolipidemic women than in controls (P <0.01). The LDL-cholesterol/apoB ratio was lower in type 2 diabetic women than in type 2 diabetic men (P <0.05). The MDA/LDL-cholesterol ratio was negatively correlated with the LDL-cholesterol/apoB ratio (r = −0.78, P <0.001) in hyperlipidemic type 1 (not type 2) diabetic patients. In normolipidemic type 2 diabetic patients, the MDA/LDL-cholesterol ratio was also negatively correlated with the LDL-cholesterol/apoB ratio (r = −0.75, P <0.001) because of the highly significant negative correlation in type 2 diabetic women (r = −0.89, P <0.01). Conclusions: LDL from well-controlled type 2 diabetic women is smaller and more prone to form peroxides. This could explain why diabetic women are at greater risk of cardiovascular disease.

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Prevalence of Metabolic Syndrome in Newly Diagnosed Type 2 Diabetes Mellitus

Cardiovascular Journal ◽

10.3329/cardio.v4i1.9385 ◽

1970 ◽

Vol 4 (1) ◽

pp. 17-25 ◽

Cited By ~ 5

Author(s):

S Nahar ◽

MZ Rahman ◽

M Ullah ◽

BC Debnath ◽

N Sultana ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Serum Triglyceride ◽

Diabetic Patients ◽

Serum Triglyceride Level ◽

Newly Diagnosed ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: People with metabolic syndrome are twice as likely to die from, and three times as likely to have a heart attack or stroke compared with people without the syndrome. People with metabolic syndrome have a five-fold greater risk of developing type 2 diabetes. We investigated the prevalence of metabolic syndrome in patients with newly diagnosed diabetes mellitus. Methods: It was a cross sectional study. The study was conducted in Department of Biochemistry, Sylhet MAG Osmani Medical College, Sylhet & Diabetic Hospital, Sylhet. The study was conducted From July 2008 to June 2009 among 200 patients with newly diagnosed type 2 diabetic patients with age >20 years. Along with blood glucose, different components of metabolic syndrome was assessed, i.e. serum triglyceride level, serum HDL level, blood pressure and waist circumference. Results- Prevalence of metabolic syndrome was 73.5% according to NCEP-ATP III criteria, 81.0% according to modified NCEP-ATP III criteria, 82.5% according to modified WHO criteria and 61.0% according to IDF criteria. All variables other than waist hip ratio and fasting blood sugar had statistically significant higher mean values among patients with metabolic syndrome than patients without metabolic syndrome. Conclusion: It may be concluded that prevalence of metabolic syndrome is considerable in newly diagnosed type 2 diabetic patients in our population. The considerable prevalence of metabolic syndrome in our population is implicative of an alarming risk of cardiovascular disease in future. Keywords: Metabolic syndrome; Type II diabetes mellitus. DOI: http://dx.doi.org/10.3329/cardio.v4i1.9385 Cardiovasc. J. 2011; 4(1): 17-25

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Gender Influence on Resting Metabolic Rate and Adipocytokines Levels in Newly Diagnosed Type 2 Diabetic Patients with Metabolic Syndrome

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.2478/rjdnmd-2014-0024 ◽

2014 ◽

Vol 21 (3) ◽

pp. 193-202 ◽

Cited By ~ 1

Author(s):

Andrada Mihai ◽

Cornelia Zetu ◽

Simona Carniciu ◽

Ariana Picu ◽

Laura Petcu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Carbon Dioxide Production ◽

Fat Free Mass ◽

Diabetic Patients ◽

Newly Diagnosed ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

AbstractBackground and Aims: Resting metabolic rate (RMR) is important to estimate energy requirements. Our aim was to investigate the RMR in newly diagnosed type 2 diabetic (T2DM) patients with metabolic syndrome (MS) in relation with obesity, gender, some adipokines and insulin resistance parameters. Material and Methods: 138 newly diagnosed T2DM adults were evaluated for anthropometric, clinical, biochemical parameters, and RMR. The group was subdivided according to body mass index and MS presence. Results: Determined RMR (RMRd), predicted RMR (RMRp), oxygen consumption and carbon dioxide production at rest were significantly lower for subjects with BMI < 30 kg/m2 compared to subjects with BMI ≥ 30 kg/m2 (p<0.001). RMRd positively correlated with fat-free mass (p < 0.001), waist (p < 0.001), BMI (p < 0.001), insulinemia (p = 0.021) and negatively with age (p < 0.001) and adiponectin (p = 0.027). The percent of determined from predicted RMR in subjects with MS was lower than in those without MS, but only for men (p< 0.005). Conclusions: Subjects with T2DM and MS have significantly lower than predicted RMR, compared to those without MS, indicating that they may have an energy sparing metabolism. Gender influences the energy metabolism and may play a particular role in energy the metabolism of people with T2DM and MS.

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