Novel Specific Kinase Receptor Activation Bioassays for the Human Insulin Receptor A (IR-A) and B (IR-B) To Study the Insulin-IGF System.

Mapping Intimacies ◽

10.1210/endo-meetings.2010.part2.p4.p2-169 ◽

2010 ◽

pp. P2-169-P2-169

Author(s):

AJ Varewijck ◽

MP Brugts ◽

JA Goudzwaard ◽

AM Waaijers ◽

SWJ Lamberts ◽

...

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Receptor Activation ◽

Human Insulin Receptor

Download Full-text

Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction

Diabetes ◽

10.2337/diabetes.39.1.123 ◽

1990 ◽

Vol 39 (1) ◽

pp. 123-128 ◽

Author(s):

S. Seino ◽

M. Seino ◽

G. I. Bell

Keyword(s):

Polymerase Chain Reaction ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Gene ◽

Partial Sequence ◽

Chain Reaction ◽

Insulin Receptor Gene ◽

Human Insulin Receptor ◽

Polymerase Chain

Download Full-text

Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30636-1 ◽

1990 ◽

Vol 265 (31) ◽

pp. 19143-19150

Author(s):

T Kadowaki ◽

H Kadowaki ◽

D Accili ◽

S.I. Taylor

Keyword(s):

Cell Surface ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Alpha Subunit ◽

Human Insulin Receptor

Download Full-text

Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38291-2 ◽

1990 ◽

Vol 265 (22) ◽

pp. 13248-13253 ◽

Author(s):

E M Schaefer ◽

K Siddle ◽

L Ellis

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Deletion Analysis ◽

Alpha Subunit ◽

Human Insulin Receptor

Download Full-text

Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50389-1 ◽

1992 ◽

Vol 267 (13) ◽

pp. 9065-9070

Author(s):

Y Takata ◽

N.J. Webster ◽

J.M. Olefsky

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Intracellular Signaling ◽

Human Insulin Receptor ◽

Carboxyl Terminal ◽

Tyrosine Autophosphorylation

Download Full-text

Identification of retinal insulin receptors using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor alpha-subunit. Up-regulation of neuronal insulin receptors in diabetes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)38266-8 ◽

1990 ◽

Vol 265 (29) ◽

pp. 18030-18034

Author(s):

S A Rosenzweig ◽

C Zetterström ◽

A Benjamin

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Receptors ◽

Alpha Subunit ◽

Site Specific ◽

Specific Antibodies ◽

Receptor Alpha ◽

Human Insulin Receptor ◽

Carboxyl Terminal

Download Full-text

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)61322-5 ◽

1987 ◽

Vol 262 (9) ◽

pp. 4134-4140 ◽

Author(s):

J.R. Forsayeth ◽

A. Montemurro ◽

B.A. Maddux ◽

R. DePirro ◽

I.D. Goldfine

Keyword(s):

Monoclonal Antibodies ◽

Insulin Receptor ◽

Human Insulin ◽

Negative Cooperativity ◽

Down Regulation ◽

Human Insulin Receptor

Download Full-text

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)99118-0 ◽

1991 ◽

Vol 266 (17) ◽

pp. 10995-11001

Author(s):

D.E. Moller ◽

H. Benecke ◽

J.S. Flier

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Metabolic Effects ◽

Naturally Occurring ◽

Human Insulin Receptor ◽

Receptor Mutant

Download Full-text

Insulin-stimulated serine and threonine phosphorylation of the human insulin receptor. An assessment of the role of serines 1305/1306 and threonine 1348 by their replacement with neutral or negatively charged amino acids.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54708-6 ◽

1991 ◽

Vol 266 (32) ◽

pp. 21804-21809

Author(s):

J.M. Tavaré ◽

B. Zhang ◽

L. Ellis ◽

R.A. Roth

Keyword(s):

Amino Acids ◽

Insulin Receptor ◽

Human Insulin ◽

Charged Amino Acids ◽

Human Insulin Receptor

Download Full-text

Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42456-8 ◽

1992 ◽

Vol 267 (12) ◽

pp. 8383-8389 ◽

Author(s):

A Cama ◽

M.J. Quon ◽

M de la Luz Sierra ◽

S.I. Taylor

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Tyrosine Kinase ◽

Insulin Action ◽

Kinase Activity ◽

Beta Subunit ◽

Tyrosine Kinase Activity ◽

Receptor Endocytosis ◽

Human Insulin Receptor

Download Full-text

Anti-drug antibody response in mucopolysaccharidosis type I patients treated with AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.343 ◽

2018 ◽

Vol 123 (2) ◽

pp. S126 ◽

Author(s):

Mathias Schmidt ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

William M. Pardridge

Keyword(s):

Antibody Response ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor

Download Full-text